Oral epithelial barrier function and the role of nuclear factor kappa-? pathway in the pathogenesis of aphthous ulceration

Günhan, Ömer; Günal, Armağan; Avcı, Arzu; Kurgan, Şivge; Dereci, Ömür; Kurt, Bülent; Celasun, Bülent

doi:10.4318/tjg.2013.0334

Cited by 12 publications

(7 citation statements)

References 32 publications

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“…Recent evidence suggests that the damage to epithelial integrity resulting from microorganisms also plays an important role in RAU formation. 88 It is known that RAU occurs on only nonkeratinized oral mucosa but not on keratinized oral mucosa, which may be related to the significant difference in the composition of the microbiome between keratinized mucosa and nonkeratinized mucosa. 77,89,90 Moreover, RAU is relatively rare in smokers, while the oral microbiomes in smokers and nonsmokers are obviously dissimilar.…”

Section: Microbiome-infected Cytotoxic T Lymphocytes Cause Recurrent Aphthous Ulcermentioning

confidence: 99%

Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis

et al. 2021

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Oral mucosal disease (OMD), which is also called soft tissue oral disease, is described as a series of disorders or conditions affecting the mucosa and soft tissue in the oral cavity. Its etiology is unclear, but emerging evidence has implicated the influence of the composition of the oral mucosa and saliva-resident microbiota. In turn, this dysbiosis effects the immune response balance and epithelial barrier function, followed by the occurrence and progression of OMD. In addition, oral microbial dysbiosis is diverse in different types of diseases and different disease progressions, suggesting that key causal pathogens may exist in various oral pathologies. This narrative literature review primarily discusses the most recent findings focusing on how microbial dysbiosis communicates with mucosal adaptive immune cells and the epithelial barrier in the context of five representative OMDs, including oral candidiasis (OC), oral lichen planus (OLP), recurrent aphthous ulcer (RAU), oral leukoplakia (OLK), and oral squamous cell carcinoma (OSCC), to provide new insight into the pathogenetic mechanisms of OMDs.

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Section: Microbiome-infected Cytotoxic T Lymphocytes Cause Recurrent Aphthous Ulcermentioning

confidence: 99%

Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis

et al. 2021

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“…-Research has illustrated that fire needle therapy markedly reduces the local expression levels of TLR 4, NLRP 3, and NF-κB. [32] Given the established intricate biological relationships between RAS and signaling pathways such as TLR, NF-κB, and NLRP 3, [26][27][28] it posited that the therapeutic modus operandi of fire needle in RAS treatment is closely tied to its regulatory effects on the TLR 4, NLRP 3, and NF-κB pathways. (4) Enhancement of trace element levels:…”

Section: Fire Needle Mechanismmentioning

confidence: 99%

The effectiveness of fire needle therapy in the treatment of recurrent aphthous stomatitis: A systematic review and meta-analysis

Wu,

Cheng,

et al. 2024

Medicine

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Background: Recurrent aphthous stomatitis (RAS) is common in clinical practice and imposes both physical and psychological distress on patients. Objective: This study aimed to evaluate the clinical effectiveness of fire needle therapy for the treatment of RAS, providing a basis for clinical decision-making. Methods: Eight databases, in both Chinese and English, were searched from their inception until December 2022. All randomized controlled trials (RCTs) that utilized fire needle therapy, either alone or combined with other treatments for RAS, were considered. Data evaluation and extraction were conducted independently by 2 authors. Results: The revised Cochrane Risk of Bias Version 2 tool was employed to assess the risk of bias in the included RCTs. A meta-analysis was conducted using Review Manager 5.4 and Stata 15.0. Nine RCTs involving 1469 patients were selected for inclusion. The meta-analysis revealed that, compared to a non-fire-needle control group (primarily utilizing vitamin and transfer factor treatments), fire needle therapy for RAS significantly improved the total effective rate (relative risk = 1.25, 95% confidence interval [CI] [1.14, 1.36], P < .00001), reduced the visual analogue scale score (mean difference = −1.68, 95% CI [−1.82, −1.53], P < .0001), diminished the Traditional Chinese Medicine symptom score (standardized mean difference = −1.20, 95% CI [−1.76, −0.65], P < .0001), and shortened the healing time (mean difference = −1.66, 95% CI [−2.73, −0.59], P = .002). Notably, there was no significant difference in the recurrence rate between the groups (relative risk = −0.18, 95% CI [−0.36, 0.01], P = .06). Further subgroup analysis on total efficacy rate was performed based on variables such as experimental group intervention, control group intervention, and duration of therapy to explore potential sources of heterogeneity. Conclusion: Fire needle therapy appears to be a clinically effective treatment for RAS, offering benefits such as pain alleviation, symptom improvement based on the Traditional Chinese Medicine parameters, and faster recovery. Nonetheless, the overall quality of the RCTs available raises concerns. Future research, involving high-quality RCTs, is essential to confirm the clinical efficacy and safety of this treatment. Registration number: PROSPERO (CRD42023387973).

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“…Immune dysfunction brought on by multiple triggers may be an important factor promoting the development of RAU. 169,170 PEF is acknowledged as an immunomodulator with therapeutic effects on immune-related disorders in Ayurveda. PEF can enhance cytokine secretion or directly stimulate B-lymphocytes or T-lymphocytes to regulate the overall immunity of the host.…”

Section: Recurrent Aphthous Ulcerationmentioning

confidence: 99%

“…153,171 In addition, it has been established that inflammatory pathways play a significant role in the pathophysiology of RAU. 172,173 Gunhan et al 170 found that NF-κB expression was prominent within the squamous epithelium adjacent to areas of ulceration, the endothelial cells of subepithelial vascular structures and the accompanying inflammatory cells. PEF and its main components, such as chebulagic acid, ellagic acid and corilagin, have strong anti-inflammatory effects, and especially mediated by the inhibition of NF-κB.…”

Section: Recurrent Aphthous Ulcerationmentioning

confidence: 99%

Phyllanthus emblicafruits: a polyphenol-rich fruit with potential benefits for oral management

Li¹,

Yu²,

Zhang³

et al. 2023

Food Funct.

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Oral epithelial barrier function and the role of nuclear factor kappa-? pathway in the pathogenesis of aphthous ulceration

Cited by 12 publications

References 32 publications

Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis

Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis

The effectiveness of fire needle therapy in the treatment of recurrent aphthous stomatitis: A systematic review and meta-analysis

Phyllanthus emblicafruits: a polyphenol-rich fruit with potential benefits for oral management

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