Oral Erythromycin Prophylaxis vs Watchful Waiting in Caring for Newborns Exposed to Chlamydia trachomatis

Rosenman, Marc B.; Mahon, Barbara E.; Downs, Stephen M.; Kleiman, Martin B.

doi:10.1001/archpedi.157.6.565

Cited by 49 publications

(26 citation statements)

References 40 publications

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“…The perinatal transmission rate of infection resulting in conjunctivitis is relatively high, as the risk of a newborn acquiring C. trachomatis in case of maternal carriage varies between 8-44%. Based on pooled results of previous studies, the point estimate of incidence of ophthalmia neonatorum proved to be 15% among infants exposed to C. trachomatis perinatally (Rosenman et al, 2003). The incubation period usually lasts between 5-14 days after delivery, which may be shorter in the case of an intrauterine infection due to PROM.…”

Section: Conjunctivitis or Ophthalmia Neonatorummentioning

confidence: 99%

“…Based on analysis of the results of this selective prevention programme only a close observation of these infants was suggested. Oral erythromycin treatment is recommended now exclusively for those newborns who develop symptoms of infection (Rosenman et al, 2003). In the absence of a harmless, even systematically effective ideal drug, prevention depends on the prenatal screening and/or on the early treatment of a manifestating C. trachomatis infection.…”

Section: Conjunctivitis or Ophthalmia Neonatorummentioning

confidence: 99%

“…Based on pooled published data point estimate of incidence of pneumonia was calculated 7% among infants exposed to C. trachomatis perinatally. The estimated rate of hospitalisation is 20% among newborns suffering from pneumonia, which makes it the most significant complication of C. trachomatis infection (Rosenman et al, 2003).…”

Section: Respiratory Tract Infectionsmentioning

confidence: 99%

See 2 more Smart Citations

Chlamydia trachomatis Infections in Neonates

Balla¹,

Petrovay²

2012

Chlamydia

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Section: Conjunctivitis or Ophthalmia Neonatorummentioning

confidence: 99%

Section: Conjunctivitis or Ophthalmia Neonatorummentioning

confidence: 99%

Section: Respiratory Tract Infectionsmentioning

confidence: 99%

See 1 more Smart Citation

Chlamydia trachomatis Infections in Neonates

Balla¹,

Petrovay²

2012

Chlamydia

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“…Crianças infectadas podem ser assintomáticas 12 . Os casos sintomáticos podem ter graus de gravidade diversos: apenas cerca de 30% dos lactentes infectados desenvolvem pneumonia 21 e 20% necessitam de hospitalização 22 . Este estudo determinou a prevalência de infecção por C. trachomatis em lactentes hospitalizados e, por isso, com forma mais grave de doença.…”

Section: Achados Radiológicosunclassified

Chlamydia trachomatis: a major agent of respiratory infections in infants from low-income families

Souza

Girão²,

Simões³

et al. 2012

J Pediatr (Rio J)

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Objectives: To determine the prevalence of lower respiratory tract infection (LRTI) due to Chlamydia trachomatis in newborn infants and to describe the clinical, laboratory, and radiological characteristics of the disease. Methods:A cross-sectional study carried out over a 12-month period. All infants up to 6 months of age admitted consecutively at the Centro Pediátrico Professor Hosannah de Oliveira of the Universidade Federal da Bahia in Salvador, Brazil, and diagnosed with LRTI according to clinical and/or radiological criteria were included in the study. C. trachomatis infection was diagnosed by the enzyme-linked immunosorbent assay (ELISA) for the detection of IgM-class antibodies. The prevalence of LRTI by C. trachomatis was determined and the prevalence ratios for the infection and clinical or laboratory variables were calculated. Results:One hundred and fifty-one infants were submitted to serology for C. trachomatis and 15 (9.9%) tested positive. Chlamydial infection was found only in infants under 5 months of age, mainly in those aged under 2 months. Three of the infants with C. trachomatis infection were born by cesarean section. Conjunctivitis and eosinophilia had occurred in 33.3% of the cases. Chest X rays were abnormal in 92.0% of cases. There was an association between C. trachomatis infection and the duration of hospitalization exceeding 15 days (p = 0.0398) and oxygen therapy (p = 0.0484). Conclusions:There was a high prevalence of C. trachomatis respiratory infection in the population studied. The infection was associated with a more severe form of the disease, emphasizing the importance of testing pregnant women for this infection to avoid infection in the newborn infant. ResumoObjetivos: Determinar a prevalência de infecção do trato respiratório inferior (ITRI) por Chlamydia trachomatis em lactentes internados e descrever as características clínicas, laboratoriais e radiológicas da doença. Métodos:Este foi um estudo do tipo corte transversal, realizado durante um período de 12 meses. Foram incluídos todos os lactentes de até 6 meses internados consecutivamente no Centro Pediátrico Professor Hosannah de Oliveira da Universidade Federal da Bahia, em Salvador, BA, com diagnóstico clínico ou clínico-radiológico de ITRI. O diagnós-tico de infecção por C. trachomatis foi realizado através da pesquisa de anticorpos da classe IgM, utilizando-se o ensaio imunoenzimático (ELISA). A prevalência de ITRI por C. trachomatis foi determinada, e foram calculadas as razões de prevalência para essa infecção e variáveis clínicas e laboratoriais. Resultados:Cento e cinquenta e um lactentes realizaram sorologia para C. trachomatis, das quais 15 (9,9%) foram positivas. A infecção por C. trachomatis ocorreu unicamente entre os menores de 5 meses, principalmente naqueles menores de 2 meses. Três crianças com infecção por C. trachomatis nasceram de parto cesáreo. Conjuntivite e eosinofilia ocorreram em 33,3% dos casos. As radiografias de tórax se mostraram alteradas em 92% dos casos. Demonstrou-se associação ...

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“…Actualmente, ha sido asociada con embarazo ectópico, aborto, parto prematuro y rotura prematura de membranas 2-3,10-12 . El neonato adquiere la bacteria en su paso por el canal del parto y tiene riesgo de desarrollar conjuntivitis en 25-50% de los expuestos y hasta 17% de ellos desarrolla una neumonía [13][14][15] . Neisseria gonorrhoeae causa infección cervical asintomática en aproximadamente 45% de los casos.…”

Section: Introductionunclassified