Oral films: Current status and future perspectives II — Intellectual property, technologies and market needs

Borges, Ana Filipa; Silva, Cláudia L.; Coelho, Jorge F. J.; Simões, Sérgio

doi:10.1016/j.jconrel.2015.03.012

Cited by 69 publications

(43 citation statements)

References 19 publications

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“…Typical polymeric carriers used in ODF manufacturing include cellulose, starches, gums and polysaccharides, proteins, and semi-synthetic or synthetic pharmaceutical grade polymers (Borges et al, 2015b). Carrier polymer selection prerequisites for ODF formulations include solubility in water and/or diverse processing solvents, film forming properties, compatibility with wide range of APIs, safety and availability of different molecular weights/ degrees of substitution (Moritz, 2006).…”

Section: General Formulation Principlesmentioning

confidence: 99%

Orodispersible films: Towards drug delivery in special populations

Scarpa

Stegemann

Hsiao

et al. 2017

International Journal of Pharmaceutics

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Section: General Formulation Principlesmentioning

confidence: 99%

Orodispersible films: Towards drug delivery in special populations

Scarpa

Stegemann

Hsiao

et al. 2017

International Journal of Pharmaceutics

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“…One such format that has gained recent attention for its robustness and versatility is polymer strip films thanks to faster disintegration and dissolution in the oral cavity, improved patient compliance (Dixit and Puthli, 2009), and ease of continuous manufacturing (Hoffmann et al, 2011). Although best known for ease of incorporation of water-soluble drugs (Dixit and Puthli, 2009), particularly among films currently on the market (Borges et al, 2015a), recent work has explored a variety of means of incorporating poorly water-soluble drug into polymer strip films. One such method, hot melt extrusion, involves melting polymer, plasticizer, and drug together, and pumping the molten mixture through a die (Prodduturi et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Critical material attributes (CMAs) of strip films loaded with poorly water-soluble drug nanoparticles: III. Impact of drug nanoparticle loading

Krull

Moreno

et al. 2017

International Journal of Pharmaceutics

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Polymer strip films have emerged as a robust platform for poorly water-soluble drug delivery. However, the common conception is that films cannot exceed low drug loadings, mainly due to poor drug stability, slow release, and film brittleness. This study explores the ability to achieve high loadings of poorly water-soluble drug nanoparticles in strip films while retaining good mechanical properties and enhanced dissolution rate. Aqueous suspensions containing up to 30 wt% griseofulvin nanoparticles were prepared via wet stirred media milling and incorporated into hydroxypropyl methylcellulose (HPMC) films. Griseofulvin loading in films was adjusted to be between 9–49 wt% in HPMC-E15 films and 30–73 wt% in HPMC-E4M films by varying the mixing ratio of HPMC solution-to-griseofulvin suspension. All films exhibited good content uniformity and nanoparticle redispersibility up to 50 wt% griseofulvin, while E4M films above 50 wt% griseofulvin had slightly worse content uniformity and poor nanoparticle redispersibility. Increasing drug loading in films generally required more time to achieve 100% release during dissolution, although polymer–drug clusters dispersed from E4M films above 50 wt% griseofulvin, resulting in similar dissolution profiles. While all films exhibited good tensile strength, a significant decrease in percent elongation was observed above 40–50 wt% GF, resulting in brittle films.

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“…świadczy liczba zarejestrowanych preparatów przeznaczonych do stosowania w terapii chorób ośrodkowego układu nerwowego, a także jako preparaty przeciwwymiotne i rozszerzające naczynia krwionośne [6]. W tabeli 1 podano przykłady dostępnych leków w postaci filmów ODF [8][9][10].…”

Section: Wprowadzenieunclassified

Orodispersible films (ODF) in individualized therapy

Łyszczarz¹,

Niwiński²,

Jachowicz³

2019

Farm Pol.

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Orodispersible films (ODF) in individualized therapy • One of the mains factors affecting the effectiveness and safety of the therapy is the development of an appropriate dosage form adapted to the age of the patients and ease to administer as well as a dosing devices that provide flexible dosing. This approach is in accordance with the idea of patientcentered treatment. Given advantages such as safety, easy swallowing and flexible dose adjustment, special attention is paid to oral dosage forms such as orally disintegrating tablets, minitablets and orodispersible films (ODF). The ODF films are indicated as a suitable dosage form for pediatric, geriatric and uncooperative patients due to their fast disintegration in the mouth without need for water to facilitate swallowing, adhesion to the oral cavity to prevent spitting out the medicine and the ability to adjust the dose of the drug for an individual patient. According to many studies, orodispersible films are well accepted by infants and preschool children, their caregivers (nurses) and parents. They have the form of a postage stamp sized strip of thin polymeric film applied on the tongue. The ODF films can be manufactured using various methods, i.e. casting method, hot melt extrusion, electrospinning or printing (inkjet, flexographic and 3D printing) on an industrial scale and potentially in hospital pharmacies. Extemporaneous preparation of the ODF films create more dose flexibility affecting patient's adherence to pharmacotherapy. Innovative solutions in this area concern also designed specifically devices for storage and dosing of ODF, as well as methods of labeling and identification of single doses, for example Quick Response (QR) codes. The paper presents a review of the literature from recent years regarding new technology in the terms of the ODF films preparation, including manufacturing methods and modification of the drug release, as well as the possibilities of their application in individualization of the therapy especially in pediatric and geriatric population.

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Oral films: Current status and future perspectives II — Intellectual property, technologies and market needs

Cited by 69 publications

References 19 publications

Orodispersible films: Towards drug delivery in special populations

Orodispersible films: Towards drug delivery in special populations

Critical material attributes (CMAs) of strip films loaded with poorly water-soluble drug nanoparticles: III. Impact of drug nanoparticle loading

Orodispersible films (ODF) in individualized therapy

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