Oral immunotherapy with low allergenic hydrolysed egg in egg allergic children

Giavi, Stavroula; Vissers, Yvonne M.; Muraro, Antonella; Lauener, Roger; Konstantinopoulos, Anastasios P; Mercenier, Annick; Wermeille, Antoine; Lazzarotto, Francesca; Frei, Remo; Bonaguro, Roberta; Summermatter, Selina; Nutten, Sophie; Papadopoulos, Nikolaos G.

doi:10.1111/all.12905

Cited by 48 publications

(55 citation statements)

References 23 publications

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“…Egg used for OIT can be given (depending on the aim) as pasteurized raw egg white (many adverse events reported), extensively heated egg (boiled white and yolk and/or well‐cooked omelette), and baked egg products . Dehydrated egg white in powder is another possibility …”

Section: Methodsmentioning

confidence: 99%

“…Egg used for OIT can be given (depending on the aim) as pasteurized raw egg white (many adverse events reported), 67 extensively heated egg (boiled white and yolk and/or well-cooked omelette), and baked egg products. [74][75][76] Dehydrated egg white in powder is another possibility. 74 OIT with peanut has been performed with defatted peanut flour, 20,21 crushed roasted peanuts, 77 and boiled peanuts.…”

Section: Type Of Food In Oitmentioning

confidence: 99%

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Allergen immunotherapy for IgE‐mediated food allergy: There is a measure in everything to a proper proportion of therapy

Pajno

Castagnoli

Muraro³

et al. 2019

Pediatric Allergy Immunology

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IgE‐mediated food allergy (FA) is a potentially life‐threatening condition with a negative impact on quality of life and an increasing prevalence in westernized countries in the recent two decades. A strict avoidance of the triggering food(s) represents the current standard approach. However, an elimination diet may be difficult and frustrating, in particular for common foods, (eg, milk, egg, and peanut). Food allergy immunotherapy (FA‐AIT) may provide an active treatment that enables to increase the amount of food that the patient can intake without reaction during treatment (ie, desensitization), and reduces the risk of potential life‐threatening allergic reaction in the event of accidental ingestion. However, several gaps need still to be filled. A memorable Latin orator stated: “Est modus in rebus” (Horace, Sermones I, 1, 106‐07). This sentence remembers that there is a measure in everything to a proper proportion of therapy. The common sense of measure should find application in each stage of treatment. A personalized approaching should consider the specific willing and features of each patient. Efforts are devoted to improve the efficacy, the safety but also the quality of life of patients suffering from FA. In the near future, it will be important to clarify immunologic pathways of FA‐AIT, and to identify reliable biomarkers in order to recognize the most suitable candidates to FA‐AIT and algorithms for treatments tailored on well‐characterized subpopulations of patients.

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Section: Methodsmentioning

confidence: 99%

Section: Type Of Food In Oitmentioning

confidence: 99%

Allergen immunotherapy for IgE‐mediated food allergy: There is a measure in everything to a proper proportion of therapy

Pajno

Castagnoli

Muraro³

et al. 2019

Pediatric Allergy Immunology

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show abstract

“…50 A recent pilot study evaluated oral immunotherapy with hydrolysed egg in children. 51 Although a 6-month treatment course in a small number of patients was not enough to demonstrate a statistically significant difference in the proportion of patients who became tolerant to egg, they found that patients treated with hydrolysed egg demonstrated increased specific IgG4 and decreased basophil activation as compared to patients treated with placebo, suggesting a trend toward tolerance.…”

Section: Peptide Immunotherapymentioning

confidence: 99%

The current state of food allergy therapeutics

Chen

Land

2017

Human Vaccines & Immunotherapeutics

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The prevalence of IgE mediated food allergy is an increasing public health concern. The current standard of treatment is strict avoidance of the offending food(s). There are no FDA approved treatments for food allergy. This review will provide an overview of strategies currently under investigation for the treatment of food allergy. The main focus of research has been directed at various forms of immunotherapy, including oral, sublingual and epicutaneous delivery routes. While oral immunotherapy (OIT) has shown the greatest promise for efficacy in terms of amount of protein that can be ingested, it has also demonstrated less tolerability and a less favorable safety profile as compared to sublingual immunotherapy (SLIT) and epicutaneous immunotherapy (EPIT), which offers the least protection but has the best safety and tolerability profile. Investigation is also underway for modified antigens that may be used for immunotherapy and for adjuncts that may help facilitate immunotherapy, including biologics such as anti-IgE therapy, and also probiotics. There are also a number of preclinical concepts that are being evaluated to manipulate the antigens and/or the immune system that may one day be translatable to patients.

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“…HydE induced a modulation of the immune response toward better tolerance. A longer treatment period may improve the clinical outcome and should be evaluated …”

Section: Prevention Treatmentmentioning

confidence: 99%

“…A longer treatment period may improve the clinical outcome and should be evaluated. 43 The prevalence of peanut allergy in younger siblings of children with peanut allergy is around 8%, but the anaphylactic risk at the time of introduction is currently unknown, which limits our ability to best counsel parents on this issue. A prospective, double-blinded assessment of risk, diagnostic tests, and an analysis of patient preferences was carried out in 54 peanut-naive younger siblings of peanut-allergic children.…”

Section: Prevention Treatmentmentioning

confidence: 99%

Food allergy in EAACI journals (2016)

Wahn

Matricardi

Bieber

et al. 2017

Pediatric Allergy Immunology

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Over the last years we have observed considerable progress in the area of food allergy, particularly in children. This review article focusses on important contributions which have lately been published in the three journals of the European Academy of Allergy and Clinical Immunology. A better understanding of allergens as well as the mechanisms of sensitization and tolerance induction may hopefully lead to a more targeted management of food allergy in the near future.

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Oral immunotherapy with low allergenic hydrolysed egg in egg allergic children

Cited by 48 publications

References 23 publications

Allergen immunotherapy for IgE‐mediated food allergy: There is a measure in everything to a proper proportion of therapy

Allergen immunotherapy for IgE‐mediated food allergy: There is a measure in everything to a proper proportion of therapy

The current state of food allergy therapeutics

Food allergy in EAACI journals (2016)

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