Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

Abstract

Previously, we reported that the hot water extract of Hydrangea serrata leaves (WHS) and its active component, hydrangenol, possess in vitro and in vivo effects on skin wrinkles and moisturization. We conducted a randomized, double-blind, placebo-controlled trial to clinically evaluate the effect of WHS on human skin. Participants (n = 151) were randomly assigned to receive either WHS 300 mg, WHS 600 mg, or placebo, once daily for 12 weeks. Skin wrinkle, hydration, elasticity, texture, and roughness parameters were assessed at baseline and after 4, 8, and 12 weeks. Compared to the placebo, skin wrinkles were significantly reduced in both WHS groups after 8 and 12 weeks. In both WHS groups, five parameters (R1–R5) of skin wrinkles significantly improved and skin hydration was significantly enhanced when compared to the placebo group after 12 weeks. Compared with the placebo, three parameters of skin elasticity, including overall elasticity (R2), net elasticity (R5), and ratio of elastic recovery to total deformation (R7), improved after 12 weeks of oral WHS (600 mg) administration. Changes in skin texture and roughness were significantly reduced in both WHS groups. No WHS-related adverse reactions were reported. Hence, WHS could be used as a health supplement for skin anti-aging.

Anti-obesity effects of a standardized ethanol extract of Eisenia bicyclis by regulating the AMPK signaling pathway in 3T3-L1 cells and HFD-induced mice

“…Makino have been shown to possess anti-obesity effects. 36,43 In particular, we have reported the anti-photoaging effects of EEB via the MAPK/AP-1, Smad, and ROS-mediated Nrf2 pathways. 30 Since the anti-obesity effects of E. bicyclis have not been revealed to date, in this study, we evaluated the anti-obesity efficacy and revealed the molecular mechanism of EEB in differentiated 3T3-L1 preadipocytes and an HFD-induced C57BL/6 mouse model.…”

Photoprotective Effect of Fermented and Aged Mountain-Cultivated Ginseng Sprout (Panax ginseng) on Ultraviolet Radiation-Induced Skin Aging in a Hairless Mouse Model

“…The measurement of skin elasticity and roughness was performed with minor modification to the methods described in previous studies [ 20 , 21 ]. Skin elasticity was measured using a Cutometer MPA 580 (Courage and Khazaka Electronics), which works by suctioning the skin into an aperture using a probe with 450 mbar negative pressure.…”

Effect of Standardized Hydrangea serrata (Thunb.) Ser. Leaves Extract on Body Weight and Body Fat Reduction in Overweight or Obese Humans: A Randomized Double-Blind Placebo-Controlled Study

“…A hot water extract from the leaves of H. serrata was prepared in the form of a tablet. Test tablets (600 mg WHS) and placebo tablets were prepared, as described previously [ 20 ]. The placebo tablets used in this study were indistinguishable from the test tablets.…”