Oral Ionic Liquid for Transdermal Delivery and Obesity Treatment

Abstract

Obesity is currently a prerequisite for more than 70% of adults, including chronic obesity and long-term obesity. With the increase of diabetes patients in the world, it is urgent to develop effective oral drugs to replace insulin. However, the gastrointestinal tract is a main obstacle to oral drug preparations. Here, a highly effective oral drug was developed, mainly formulated as an ionic liquid (IL) prepared by L-(−)-carnitine and geranic acid. Density functional theory (DFT) calculations showed that L-(−)-carnitine and geranic acid can exist stably through hydrogen bonding. IL can significantly enhance the transdermal transport of drugs. In vitro study of intestinal permeability showed that particles formed by IL can prevent the absorption of intestinal fat. Compared with the control group, oral administration of IL (10 mL kg −1 ) significantly reduced blood glucose, white adipose tissue in the liver and epididymis, and the expression of SREBP-1c and ACC in IL. Therefore, these results and high-throughput sequencing analysis showed that IL can effectively reduce the intestinal absorption of adipose tissue to reduce blood glucose. IL has good biocompatibility and stability. Therefore, IL has a certain application value in the field of oral drug-delivery carriers, which provides an effective means for the treatment of diabetes and is a potential tool to solve the epidemic of obesity.

Enhancing Transdermal Delivery of Curcumin-Based Ionic Liquid Liposomes for Application in Psoriasis

“…From the NMR and FTIR spectra (Figures S2–S5), the curcumin succinate has been successfully prepared. ,− Subsequently, through theoretical calculation and experimental studies, we found that succinic anhydride modification at the end of curcumin (red labeled-COOH) can form an IL with betaine (blue labeled-COO – ) by hydrogen bond interaction (Figure a). Both the ESP (Figure b) and the RDG (Figure c) diagrams showed that curcumin succinate and betaine can successfully prepare Cur-Bet-IL through hydrogen force interconnection. , This IL not only has good fluidity and stability at room temperature but also maintains the biological activity of curcumin (Figure S6).…”

Ionic Liquid Pretreatment Enhances Skin Penetration of 5-Aminolevulinic Acid: A Promising Scheme for Photodynamic Therapy for Acne Vulgaris

“…Rat skin is structurally similar to human skin, and its abdominal skin is a widely accepted and utilized model for evaluating transdermal drug delivery . Therefore, the ability of the IL-facilitated transdermal delivery of ALA to excised rat abdominal skin was evaluated.…”