Oral Lichen Planus Associated With Lichen Planus Pigmentosus and Lichen Sclerosus in Monozygotic Twins

Marques, Letícia Côgo; Santos, Lílian Rocha; Silva, Natasha Camargo Da; Cunha, Karin Soares Gonçalves; Silva, Arley; Conde, Danielle Castex

doi:10.1097/dad.0000000000001847

Cited by 3 publications

(3 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure 2 shows that discoid lupus is highly associated with both lichen planus and lichen sclerosis and often overlap clinically [ 57 ]. Figure 3 shows they are also associated with sarcoidosis, erythema nodosum, and pyoderma gangrenosum, underlining a common genetic etiology [ 58 ].…”

Section: Resultsmentioning

confidence: 99%

Autoimmune Disease Classification Based on PubMed Text Mining

Samuels

Malov

Saha

et al. 2022

JCM

View full text Add to dashboard Cite

Autoimmune diseases (AIDs) are often co-associated, and about 25% of patients with one AID tend to develop other comorbid AIDs. Here, we employ the power of datamining to predict the comorbidity of AIDs based on their normalized co-citation in PubMed. First, we validate our technique in a test dataset using earlier-reported comorbidities of seven knowns AIDs. Notably, the prediction correlates well with comorbidity (R = 0.91) and validates our methodology. Then, we predict the association of 100 AIDs and classify them using principal component analysis. Our results are helpful in classifying AIDs into one of the following systems: (1) gastrointestinal, (2) neuronal, (3) eye, (4) cutaneous, (5) musculoskeletal, (6) kidneys and lungs, (7) cardiovascular, (8) hematopoietic, (9) endocrine, and (10) multiple. Our classification agrees with experimentally based taxonomy and ranks AID according to affected systems and gender. Some AIDs are unclassified and do not associate well with other AIDs. Interestingly, Alzheimer’s disease correlates well with other AIDs such as multiple sclerosis. Finally, our results generate a network classification of autoimmune diseases based on PubMed text mining and help map this medical universe. Our results are expected to assist healthcare workers in diagnosing comorbidity in patients with an autoimmune disease, and to help researchers in identifying common genetic, environmental, and autoimmune mechanisms.

show abstract

Section: Resultsmentioning

confidence: 99%

Autoimmune Disease Classification Based on PubMed Text Mining

Samuels

Malov

Saha

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…Previous studies reported that LPP can occur with lichen planus (LP), as active or resolving LP lesions can be found in patients with LPP [ 5 , 13 ]. LPP also coexists with other variants of LP such as lichen planopilaris [ 14 ] and oral lichen planus (OLP) [ 15 – 17 ]. One study showed that LPP also correlates with autoimmune diseases such as Sjogren's syndrome, Crohn's disease, and rheumatoid arthritis [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Oral Chronic Mucositis in a Known Lichen Planus Pigmentosus Patient

Pinchaleaw,

Limlawan

2024

Case Reports in Dentistry

View full text Add to dashboard Cite

Oral manifestations of mucocutaneous inflammatory diseases such as lichenoid dermatoses often affect the patient’s quality of life through the symptoms of pain and burning sensation. In this case report, a patient with known lichen planus pigmentosus (LPP), a variant of lichenoid dermatoses that rarely affect oral mucosa, presented with chronic pain in the oral cavity for 2 months. Her intraoral examination revealed multiple pseudomembranous ulcers with erythematous areas and white striae similar to erosive lichen planus. The histological assessment revealed chronic mucositis, while the direct immunofluorescent examination showed negative results, contradicting the diagnosis of both lichen planus and LPP. Thus, the diagnosis was given as chronic mucositis, and the topical steroid was given. After 6 weeks of steroid application, the lesion resolved. To the best of our knowledge, this is the first report of chronic mucositis in LPP patients. This report could raise the awareness of clinicians to carefully take history as the patient with LPP may suffer from chronic mucositis in the oral cavity as well.

show abstract

“…While the influence of genetic factors remains uncertain, instances of Lichen Planus (LP) affecting multiple family members have been reported. Notably, a case involving two monozygotic twin sisters with oral LP has been documented, and one of them additionally exhibited LPP [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Lichen Planus Pigmentosus with True Melanocytic Nests: A Case Report with a Comprehensive Literature Review

Podo Brunetti,

Bigotto,

Stabile

et al. 2023

Dermatopathology

View full text Add to dashboard Cite

Lichen Planus Pigmentosus (LPP) is an uncommon variant of lichen planus characterized by the development of dark greyish-brown macules and patches primarily affecting sun-exposed areas. Histologically, it presents with lichenoid interface dermatitis with many melanophages. In select cases, the presence of melanocytic nests or pseudomelanocytic nests within LPP lesions has been documented, posing a diagnostic challenge. We present a detailed case report of a 32-year-old Eritrean woman with a longstanding history of hyperpigmented macules, alongside an in-depth review of the existing literature on lichenoid dermatoses featuring melanocytic or pseudomelanocytic nests. This paper delves into the clinical presentation, histopathological features, differential diagnosis, and potential mechanisms underlying this intriguing phenomenon.

show abstract

Oral Lichen Planus Associated With Lichen Planus Pigmentosus and Lichen Sclerosus in Monozygotic Twins

Cited by 3 publications

References 47 publications

Autoimmune Disease Classification Based on PubMed Text Mining

Autoimmune Disease Classification Based on PubMed Text Mining

Oral Chronic Mucositis in a Known Lichen Planus Pigmentosus Patient

Lichen Planus Pigmentosus with True Melanocytic Nests: A Case Report with a Comprehensive Literature Review

Contact Info

Product

Resources

About