Oral Lichen Planus in Thai Patients Has a Low Prevalence of Human Papillomavirus

Arirachakaran, Pratanporn; Chansaengroj, Jira; Lurchachaiwong, Woradee; Kanjanabud, Patnarin; Thongprasom, Kobkan; Poovorawan, Yong

doi:10.1155/2013/362750

Cited by 15 publications

(19 citation statements)

References 37 publications

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“…The main information of the 22 selected studies is listed in Table 1 . The analysis covered 12 countries, 5 of Asia, specifically China [ 16 – 20 ], India [ 9 , 10 ], Iran [ 21 ], Thailand [ 22 ], and Turkey [ 23 ]; 6 in Europe, specifically Italy [ 12 , 13 , 24 , 25 ], Hungary [ 26 , 27 ], England [ 5 , 11 ], Germany [ 8 ], Ireland [ 28 ], and Sweden [ 29 ]; 1 in North American, specifically the United States [ 7 ].…”

Section: Resultsmentioning

confidence: 99%

The Magnitude of the Association between Human Papillomavirus and Oral Lichen Planus: A Meta-Analysis

Zhang

et al. 2016

PLoS ONE

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BackgroundThe role of human papilloma virus (HPV) in oral lichen planus (OLP) is controversial.ObjectivesThe primary aim of the current study is to calculate the pooled risk estimates of HPV infection in OLP when compared with healthy controls.MethodsBibliographic searches were conducted in three electronic databases. Articles on the association between HPV and OLP were selected from case-control studies or cross-sectional studies, following predefined criteria. Pooled data were analyzed by calculating odds ratios (OR) and 95% confidence interval (CI).ResultsOf the 233 publications identified, 22 case-control studies met the inclusion criteria. Collectively, 835 cases and 734 controls were available for analysis. The summary estimate showed that OLP patients have significantly higher HPV prevalence (OR: 6.83; 95% CI: 4.15–11.27) than healthy controls. In subgroup analyses, the association of HPV and OLP varied significantly by geographic populations. The ORs ranged from 2.43 to 132.04. The correlation of HPV and erosive-atrophic oral lichen planus (EA-OLP) (OR: 9.34) was comparable and well above that of HPV and non-EA-OLP (OR: 4.32). Among HPV genotypes, HPV 16 showed an extremely strong association with OLP (OR: 11.27), and HPV 18 showed a relatively strong one (OR: 6.54).ConclusionIn conclusion, a significant association was found between HPV and OLP. The strength of the association varied across geographic populations, clinical types of OLP, and HPV genotypes. The results suggest that HPV might play an important causal role in OLP and in its malignant to progression.

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Section: Resultsmentioning

confidence: 99%

The Magnitude of the Association between Human Papillomavirus and Oral Lichen Planus: A Meta-Analysis

Zhang

et al. 2016

PLoS ONE

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“…Likewise, HPV-DNA has been observed in a small proportion (6.4%) of dysplasias in preliminary results of a recent Canadian study [20]. Regarding OLP, a low HPV-DNA prevalence was reported in thirty-seven fresh-frozen tissue biopsy specimens from OLP lesions tested for HPV-DNA where only one sample was positive [34]. Other studies [35,36] also showed very low prevalence in OLP and premalignant conditions.…”

Section: Discussionmentioning

confidence: 96%

Human papillomavirus in premalignant oral lesions: No evidence of association in a Spanish cohort

Gómez-Armayones

Küstner²,

Roig

et al. 2019

PLoS ONE

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BackgroundHuman papillomavirus (HPV) is the cause of a fraction of head and neck squamous cell carcinoma. Although this relation is well-known, it is still not clear the role of HPV in premalignant oral lesions such as oral lichen planus (OLP) and dysplasia. We aimed to evaluate the HPV-DNA prevalence and type distribution in a set of oral biopsies obtained from patients diagnosed with OLP and dysplasia, as well as the role of HPV in these lesions.MethodsA retrospective cohort of all premalignant oral lesions consecutively diagnosed from March 30th 1995 to May 21st 2014 at Hospital of Bellvitge and Odontological University Hospital of Bellvitge was identified and classified in four groups: OLP (groups 1 and 2) and dysplasias (groups 3 and 4) that progressed or not to invasive cancer during follow-up. A random selection targeting 25 cases was aimed to be performed for each group. All selected cases were subjected to pathological evaluation, DNA quality control and HPV-DNA detection. HPV-DNA positive samples were further subject to p16INK4a analysis.ResultsA total of 83 cases yielded a valid HPV-DNA result. From those, 7 and 34 cases were OLP that progressed or not to invasive cancer during follow-up, whereas 24 and 18 cases were displasias that progressed or not to invasive cancer during follow-up, respectively. HPV-DNA was detected in 4 samples (3 dysplastic lesions and 1 OLP). Two samples were HPV16 positive (2%), 1 sample HPV18 positive (1%) and 1 sample (1%) was HPV indeterminate. Two out of four HPV-DNA positive cases had high p16INK4a expression and none of the HPV positive cases progressed to invasive cancer during long-term follow-up.ConclusionsWe found a low HPV-DNA attributable fraction in premalignant lesions of the oral cavity, suggesting that HPV is unlikely to play a significant role in oral carcinogenesis in our setting.

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“…It has been reported in many studies that the most common type of HPV infection in OLP is HPV-16 infection 11,20,24,35,36) .…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus in Oral Lichen Planus of Japanese Patients

Kato

Kawai

Isomura

et al. 2015

J. Hard Tissue Biology.

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Oral lichen planus (OLP) can undergo malignant transformation and become squamous cell carcinoma (SCC). Oral infection with human papillomavirus (HPV) is associated with a significant risk of developing oral cancer. Although HPV DNA is detected more often in OLP tissue than in normal oral mucosa, there is as yet no firm evidence that HPV is a causative factor of malignant transformation in OLP. The objective of the present investigation was to assess HPV-genotype distribution in OLPs of Japanese patients and additionally to clarify the relationship between malignant transformation in OLP and HPV infection using PCR, in situ hybridization, and immunohistochemistry. DNA of 200 formalin-fixed, paraffin-embedded biopsy and surgical specimens of OLP was extracted. HPV infection was first detected by PCR using consensus HPV primers. Positive PCR samples were then further analyzed by PCR using HPV type-specific primers (HPV-6, -11, -16, -18 and -33). Eighty-three samples (41.5 %) out of the total 200 OLP specimens analyzed were HPV positive. In the HPV type-specific PCR assay, the most frequent type of HPV was HPV-16 (25.5 %), which is a high-risk type of HPV that is associated with malignant disorders and is often detected in SCC. The highest HPV-16 positive rate was obtained for the erosive type of OLP (28.3 %). Positive staining for HPV DNA by in situ hybridization was observed in the nuclei of cells in all layers of the epithelium in all HPV PCR positive samples. Immunohistochemically, nuclei of cells in the upper layer of the epithelium in all HPV PCR positive samples stained positive for the anti-HPV antibody. These results indicated that HPV-16 was often present in OLP of Japanese patients, especially in the erosive type of OLP, and suggested that HPV infection is a risk factor for malignant transformation in OLP lesions.

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Oral Lichen Planus in Thai Patients Has a Low Prevalence of Human Papillomavirus

Cited by 15 publications

References 37 publications

The Magnitude of the Association between Human Papillomavirus and Oral Lichen Planus: A Meta-Analysis

The Magnitude of the Association between Human Papillomavirus and Oral Lichen Planus: A Meta-Analysis

Human papillomavirus in premalignant oral lesions: No evidence of association in a Spanish cohort

Human Papillomavirus in Oral Lichen Planus of Japanese Patients

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