Oral Localized Amyloidosis

Yamagata, Kenji; Bukawa, Hiroki

doi:10.5772/19191

Cited by 2 publications

(3 citation statements)

References 40 publications

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“…Tissue biopsy is mandatory for histological confirmation. Current recommendations regarding amyloidosis diagnosis are the following: i) Congo red stain is currently the gold standard for amyloid detection; ii) the type of amyloid must be identified microscopically or immunohistochemically, not solely on clinical or DNA studies; iii) immunohistochemistry has to be performed cautiously and amyloidosis suspicion must be completed using more sophisticated methods in referral centers (22).…”

Section: Discussionmentioning

confidence: 99%

Rare amyloidoma of the tongue base: A case report and review of the literature

et al. 2020

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Localized amyloidosis is a rare condition characterized by the deposition of misfolding protein in a tissue, without other systemic manifestations. Only a small number of cases of localized amyloidosis of the tongue have been reported to date, in contrast to systemic amyloidosis, in which localization on the tongue is common. This study presents a rare case of localized amyloidosis of the tongue (amyloidoma) and provides a summary of the known literature of localized amyloidosis. This study describes the case of a 36-year-old female who presented with a swelling of the tongue base. The diagnosis of amyloidoma was made based on the findings of the physical examination, head and neck MRI findings and the histopathological examination with Congo red stain under polarized light. The histopathological diagnosis was as follows: Localized lambda light-chain amyloidosis. A thorough physical examination was performed by the ENT and Hematology/Oncology departments, without revealing signs of systemic disease. A series of hematological and imaging tests were also performed to verify that there was no sign of systemic involvement. The patient declined surgical excision and the 2-year follow-up did not reveal any changes in tumor dimension. Although the etiology of localized amyloidosis is yet not clear, the prolonged reaction of tissue plasma cells to environmental antigens may be a causative factor for the initiation of the neoplastic process.

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Section: Discussionmentioning

confidence: 99%

Rare amyloidoma of the tongue base: A case report and review of the literature

et al. 2020

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“…These deposits are derived from misfolded proteins that aggregate to form linear fibrils with an approximate diameter of 7.5–10 nm and a cross b-pleated sheet conformation, evidenced by X-ray diffraction. [ 1 ] Amyloidosis may be systemic or localized to a single organ, such as lungs, brain, or skin. According to some authors, the localized form has a better prognosis, particularly when the head and neck area is affected.…”

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confidence: 99%

“…The specific type of amyloid fibril can be further determined by immunohistochemical staining or immunoelectron microscopy. [ 1 ]…”

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confidence: 99%