Oral micronized progesterone

Lignières, B. De

doi:10.1016/s0149-2918(00)88267-3

Cited by 103 publications

(98 citation statements)

References 69 publications

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“…This was accomplished by having oral micronized progesterone compounded by the Women's International Pharmacy as 50 mg capsules. During each inpatient phase, participants were administered 150 mg oral micronized progesterone or matching placebo capsules at 2300 h on the evening before the first cocaine session since steady-state levels are reached after the second dose (de Lignieres, 1999). Then, on the next two consecutive days, participants were administered 150 mg oral micronized progesterone or matching placebo capsules at 0700 and 1100 h, approximately 2 h before each cocaine session, since oral micronized progesterone levels peak in 1-3 h (Simon et al, 1993).…”

Section: Progesterone Dosingmentioning

confidence: 99%

“…The most common reported side effects of oral micronized progesterone administration are dizziness and sedation (Simon et al, 1993; see review by de Lignieres, 1999). Most studies that have administered oral progesterone to females report transient increases in sedation and modest performance impairment.…”

Section: Subjective Effectsmentioning

confidence: 99%

“…Clinically, oral micronized progesterone is used for hormone replacement therapy (often in conjunction with estrogens) in postmenopausal women, for a variety of bleeding disorders, as well as for secondary amenorrhea (Shangold et al, 1991;de Lignieres, 1999;Fitzpatrick and Good, 1999). For these conditions, the standard dose is typically 100-300 mg/day for a period of several days up to 2 weeks each menstrual cycle.…”

Section: Subjective Effectsmentioning

confidence: 99%

“…This was critical since the purpose was to determine the effects of physiological levels of exogenous progesterone comparable to the normal midluteal phase on the response to cocaine. We gave an oral dose of 150 mg micronized progesterone the evening before the first cocaine session because steadystate plasma levels are achieved after the second dose (see review by de Lignieres, 1999). Also, our progesterone doses were custom-made, allowing us to administer 150 mg micronized progesterone, rather than the commercially available 100 or 200 mg doses.…”

Section: Subjective Effectsmentioning

confidence: 99%

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Exogenous Progesterone Attenuates the Subjective Effects of Smoked Cocaine in Women, but not in Men

Evans

Foltin

2005

Neuropsychopharmacol

191

221

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In a previous study, we showed that the positive subjective effects of cocaine were higher during the follicular phase compared to the luteal phase of the menstrual cycle. The purpose of the present study was to determine if exogenously administered progesterone during the follicular phase in females would attenuate the response to cocaine compared to the normal follicular phase, thus making the response to cocaine similar to the luteal phase. To address the role of sex differences, males were also administered exogenous progesterone during one inpatient stay. In all, 11 female and 10 male non-treatment-seeking cocaine smokers participated. Females had three inpatient stays: one during a normal follicular phase, one during a normal luteal phase, and one during a follicular phase when exogenous progesterone was administered. Males had two inpatient stays: one when exogenous progesterone was administered and the other when placebo was administered. During each inpatient admission, there were four smoked cocaine administration sessions: participants were administered six doses of cocaine (0, 6, 12, or 25 mg cocaine base) at 14 min intervals. Smoked cocaine increased heart rate, blood pressure and several subjective effects such as 'good drug effect' and 'drug quality' cluster scores. Administration of progesterone during the follicular phase in women attenuated the positive subjective effects of cocaine, whereas only minimal changes were observed in men. These results indicate that progesterone modulates the response to cocaine in women and suggests that fluctuations in endogenous progesterone levels account for some of the sex differences observed in humans.

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Section: Progesterone Dosingmentioning

confidence: 99%

Section: Subjective Effectsmentioning

confidence: 99%

Section: Subjective Effectsmentioning

confidence: 99%

Section: Subjective Effectsmentioning

confidence: 99%

See 2 more Smart Citations

Exogenous Progesterone Attenuates the Subjective Effects of Smoked Cocaine in Women, but not in Men

Evans

Foltin

2005

Neuropsychopharmacol

191

221

View full text Add to dashboard Cite

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“…No caso dos hormônios, temos a progesterona, extraída da Dioscorea villosa e modificada em laboratório para atingir uma fórmula estrutural semelhante à produzida pelo ovário (3).…”

Section: Conceitounclassified

Fitoestrogênios: posicionamento do Departamento de Endocrinologia Feminina da Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)

Clapauch

Meirelles

Julião

et al. 2002

Arq Bras Endocrinol Metab

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Para avaliar a utilidade dos fitoestrogênios (FE) na terapia de reposição hormonal da menopausa (TRHM), o Departamento de Endocrinologia Feminina da SBEM reuniu um grupo de especialistas para fazer uma revisão bibliográfica e selecionar trabalhos nos quais a metodologia adotada demonstrasse rigor científico. Os FE têm ações estrogênicas e antiestrogênicas, predominantemente sobre os receptores de estrogênios (E) beta, com potência estrogênica muito inferior à do estradiol. O conteúdo de FE nas suas fontes vegetais é variável, dependendo da forma de cultivo, safra, armazenamento e industrialização. Também a conversão dos precursores em fitormônios ativos no organismo humano tem grande variabilidade individual. A maior parte das pesquisas com FE é realizada in vitro ou com animais de laboratório, nem sempre podendo ser extrapoladas para humanos. Com relação à síndrome do climatério, alguns estudos sugerem discreta melhora dos fogachos, sem modificação do ressecamento vaginal ou das alterações do humor. No metabolismo lipídico, alimentação rica em soja, mas não isoflavonas isoladamente, promove redução do colesterol total, do LDL-col e dos triglicerídeos, mas não elevam o HDL-col, como os E, e podem causar aumento da lipoproteína (a), que os E contribuem para diminuir. Embora alguns estudos de curta duração sugiram aumento da densidade mineral óssea com uso de isoflavonas, não há demonstração de redução de fraturas. Conclui-se que não há evidências convincentes que justifiquem o uso de FE ou alimentação rica em soja como alternativa para a TRHM.

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