Oral Midazolam With an Antacid Increases the Speed of Onset of Sedation in Children Prior to General Anesthesia

Lammers, Cathleen R; Rosner, Julia; Crockett, D. E.; Chhokra, R.; Brock‐Utne, John G.

doi:10.1097/00000539-199902001-00297

Cited by 3 publications

(5 citation statements)

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“…At a pH of 4.0–4.5, imidazole ring of midazolam closes, making it more lipophilic. The higher pH promotes lipid solubility and accelerates absorption across mucosal membranes (16).…”

Section: Discussionmentioning

confidence: 99%

“…The midazolam/Syrpalta mixture has a pH of 4.0, higher than the premixed midazolam (pH 3.5). In a study of 40 presurgical children (16), midazolam was mixed with sodium citrate to raise the pH to 4.5 in one group, and the onset of sedation was significantly faster (P < 0.05) than in a second group that received midazolam mixed with Hawaiian Punch (pH 3.5).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, mucosal absorption of midazolam is expected to be pH dependent (16). A study in dogs using midazolam solutions of three different pHs (2.8, 3.2, and 3.9) demonstrated that both C max and AUC increase with increasing pH (17).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A paediatric trial comparing midazolam/Syrpalta mixture with premixed midazolam syrup (Roche)

Khalil¹,

Vije

Kee

et al. 2003

Pediatric Anesthesia

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“…At a pH of 4.0–4.5, imidazole ring of midazolam closes, making it more lipophilic. The higher pH promotes lipid solubility and accelerates absorption across mucosal membranes (16).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A paediatric trial comparing midazolam/Syrpalta mixture with premixed midazolam syrup (Roche)

Khalil¹,

Vije

Kee

et al. 2003

Pediatric Anesthesia

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show abstract

“…[25 ] Bradycardia and sinus arrest have been reported with dexmedetomidine. [31,39] Respiratory effects…”

Section: Cardiovascular and Hemodynamic Effectsmentioning

confidence: 99%

Dexmedetomidine:” Role in Pediatric Dentistry

Sangal¹,

Goswami²,

Nangia³

et al. 2022

APJHS

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A number of sedative agents have been in use in pediatric dentistry to gain a child’s cooperation with dental treatment. Dexmedetomidine is one such agent that was introduced as a sedative in the dental practice in 2005 due to a more stable respiratory drive and higher success rates in allowing pediatric dentists to carry out non-painful dental examinations and procedures compared to other sedatives such as chloral hydrate and midazolam. The most distinguishing feature of this sedative is its ability to produce a form of sedation that mimics natural sleep. The high safety margin of dexmedetomidine and its satisfactory sedative action makes it important for us to review its potential applications in pediatric dentistry.

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“…At a pH of 4.0–4.5, the closing of its imidazole ring occurs. This high pH leads to its high lipid solubility in and fast absorption via the oral mucosa [19]. When 0.5 mg/kg midazolam is orally administered as a premedication, its mucosal absorption is likely to be reliant on its pH [6].…”

Section: α2-adrenoreceptor Agonistsmentioning

confidence: 99%

Role of dexmedetomidine in pediatric dental sedation

Mohite¹,

Baliga²,

Thosar³

et al. 2019

J Dent Anesth Pain Med

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Dexmedetomidine is a highly selective α2-adrenoceptor agonist with a vast array of properties, making it suitable for sedation in numerous clinical scenarios. Its use was previously restricted to the sedation of intensive care unit patients. However, its use in pediatric dental sedation has been gaining momentum, owing to its high suitability when compared with conventional pediatric sedatives. Its properties range from sedation to anxiolysis to analgesia, due to its sympatholytic properties and minimal respiratory depression ability. Because dexmedetomidine is an efficacious and safe drug, it is gaining importance in pediatric sedation. Thus, the aim of this review is to highlight the properties of dexmedetomidine, its administration routes, its advantages over the commonly used pediatric sedatives, and especially its role as an alternative pediatric sedative.

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Oral Midazolam With an Antacid Increases the Speed of Onset of Sedation in Children Prior to General Anesthesia

Cited by 3 publications

References 0 publications

A paediatric trial comparing midazolam/Syrpalta mixture with premixed midazolam syrup (Roche)

A paediatric trial comparing midazolam/Syrpalta mixture with premixed midazolam syrup (Roche)

Dexmedetomidine:” Role in Pediatric Dentistry

Role of dexmedetomidine in pediatric dental sedation

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