Oral mucosal changes in pemphigus vulgaris and its treatment: A case report

Sen, Sourav; Chakraborty, Rakashree; Meshram, Mrunal; Patel, Shraddha

doi:10.4103/jfmpc.jfmpc_765_19

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Thus, PV was considered another differential diagnosis. Few studies have reported similar findings of lip lesions among PV patients [ 22 – 25 ].…”

Section: Discussionmentioning

confidence: 84%

Erythema multiforme-like lip presentation in pemphigus vulgaris patients: a multicenter case series

Subahi,

Waheeb,

Binmadi

et al. 2023

BMC Oral Health

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Pemphigus vulgaris (PV) is a chronic autoimmune mucocutaneous blistering disease. Autoantibodies are directed against desmogleins, leading to the formation of intraepithelial bullae. PV, as with other autoimmune mucocutaneous disorders of the oral cavity, presents diagnostic and therapeutic challenges. Approximately 50–70% of cases present first with oral lesions. The lesions commonly start as vesicles or bullae that rapidly rupture, leading to erosions and ulcerations. The palatal, gingival, buccal, and labial mucosa are the most commonly affected sites. Oral PV can mimic several other diseases that cause mucosal erosions and/or ulcerations, including erythema multiforme (EM). EM is an acute, immune-mediated, self-limited hypersensitivity condition primarily associated with herpes simplex infection. Oral lesions can be variable, but a very characteristic presentation with labial hemorrhagic erosions, ulcerations and crusting is commonly seen. In this case series, we present six cases of PV: one male patient and five female patients whose ages ranged from 34 to 65 years old. All patients presented with hemorrhage and crusting of the lips in addition to multiple intraoral erosions and ulcerations. Three patients presented with oral and skin lesions. All patients underwent biopsies, and a diagnosis of PV was confirmed. All patients were treated with steroids (topical and systemic) and variable steroid-sparing agents. This case series emphasizes that oral PV may be misdiagnosed as EM in a subgroup of patients who present with persistent lip hemorrhage and crusting. Therefore, a comprehensive history, clinical examination and incisional biopsies should be considered in such patients.

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“…Thus, PV was considered another differential diagnosis. Few studies have reported similar findings of lip lesions among PV patients [ 22 – 25 ].…”

Section: Discussionmentioning

confidence: 84%

Erythema multiforme-like lip presentation in pemphigus vulgaris patients: a multicenter case series

Subahi,

Waheeb,

Binmadi

et al. 2023

BMC Oral Health

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“…Guidelines set by the British Association of Dermatologists recommended treatment of Pemphigus Vulgaris in two phases: Induction phase to control the disease and maintenance phase for consolidation and treatment tapering. [1,7] Depending on the response, the dose is gradually decreased to the minimum therapeutic dose, taken once daily to minimize side effects. The cornerstone of therapeutic approach is systemic and/or local corticosteroid therapy.…”

Section: Discussionmentioning

confidence: 99%

Oral pemphigus vulgaris: A case report and review of the literature

Rishi

Chawla

Dubey

2022

AUJMSR

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The oral cavity presents with a variety of pathological lesions ranging from benign to malignant. Autoimmune mucocutaneous disorders of the oral cavity constitute an important group of lesions that pose diagnostic, therapeutic, and prognostic difficulties to the dental clinician. Many of the lesions may become potentially fatal if they are undiagnosed or misdiagnosed in their early stages. Pemphigus vulgaris is a potentially life-threatening autoimmune mucocutaneous disorder that causes blisters and erosions of the skin and the mucous membrane. It manifests clinically as vesicles, bullae, or desquamative gingivitis and histopathologically shows the presence of acantholysis. Eighty to ninety percent of patients with pemphigus vulgaris develop oral lesions and in 60% of cases, oral lesions are the first sign. Timely recognition and therapy of oral lesions are critical as they may prevent skin involvement. The incidence of pemphigus vulgaris occurs in a ratio of 2:1 (female: male). Adequate knowledge of diagnostic and therapeutic modalities helps the clinician in appropriate management. In this article, we report a case of oral pemphigus vulgaris in a 34-year-old male.

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Vesiculobullous Lesions of the Oral Cavity

Alramadhan¹,

Islam²

2023

Oral and Maxillofacial Surgery Clinics of North America

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Oral mucosal changes in pemphigus vulgaris and its treatment: A case report

Cited by 3 publications

References 9 publications

Erythema multiforme-like lip presentation in pemphigus vulgaris patients: a multicenter case series

Erythema multiforme-like lip presentation in pemphigus vulgaris patients: a multicenter case series

Oral pemphigus vulgaris: A case report and review of the literature

Vesiculobullous Lesions of the Oral Cavity

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