Oral plasmablastic lymphoma in an HIV-negative patient: A case report and review of the literature

Scheper, Mark A.; Nikitakis, Nikolaos G.; Fernandes, Rui Aniceto Nascimento; Gocke, Christopher D.; Ord, Robert A.; Sauk, John J.

doi:10.1016/j.tripleo.2004.11.050

Cited by 70 publications

(92 citation statements)

References 23 publications

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“…Originally PBL was described in the oral cavity region although, many reports of patients without HIV and outside the head and neck area have been recently presented in the literature [10,13,[16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Plasmablastic Lymphoma in a Previously Undiagnosed Aids Patient: A Case Report

Vieira

Gandour

Buadi

et al. 2008

Head and Neck Pathol

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Background Plasmablastic lymphoma (PBL) is an unusual non-Hodgkin lymphoma (NHL) most commonly found in the head and neck region. The majority of cases are seen in adult HIV-positive patients, although PBL has been reported in HIV-negative patients. The diagnosis of PBL serves as an AIDS-defining illness. Methods We report a case of PBL localized to the oral cavity in a previously undiagnosed AIDS patient. The lesion manifested as solitary, ulcerated, and markedly tender. PBL was confirmed by immunohistochemical profile and subsequent tests confirmed AIDS diagnosis. The patient was prescribed highly active antiretroviral therapy (HAART) and concomitant local low dose radiation therapy prior to initiation of chemotherapy. Results Complete local clinical response was observed after 4 weeks of treatment with HAART and radiation therapy. The response sustained in this patient in the subsequent 11 months following diagnosis. Conclusions The diagnosis of PBL has a unique immunophenotypic profile and should raise suspicion for AIDS in these patients. HAART added to treatment has shown improved survival.

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Section: Discussionmentioning

confidence: 99%

Plasmablastic Lymphoma in a Previously Undiagnosed Aids Patient: A Case Report

Vieira

Gandour

Buadi

et al. 2008

Head and Neck Pathol

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“…Subsequent publications with larger case studies have shown that PBL is not restricted to the oral cavity, but may also present at other mucosal sites in the head and neck, bone, soft tissue, gastrointestinal tract, and spermatic cord [3,8]. Although the majority of these cases occur in association with HIV-infection, a small subset is associated with immunosuppression after solid organ transplantation or steroid therapy and very rare cases occur in immunocompetent patients [1,6,9]. Morphology of these subsequently reported cases vary from a monotonous proliferation of lymphoid cells with immunoblastic features and minimal plasmacytic differentiation to a variable mixture of large immunoblasts and plasmablasts with cells showing differentiation to mature plasma cells [1,9].…”

Section: Discussionmentioning

confidence: 99%

“…Immunophenotyping consistently shows strong CD138 and VS38c expression, variable expression of CD79a, EBER reactivity in the majority of cases, and absent or very weak expression of CD20 [1][2][3][4][5][6]. The clinical behavior has been reported as highly aggressive with generally poor response to therapy and short survival ranging between 1 and 28 months after diagnosis [1,4,9].…”

Section: Discussionmentioning

confidence: 99%

“…The neoplastic cells in PBL are generally blastic in appearance and show strong expression of plasma cellassociated antigens such as CD38 and CD138 and weak to absent expression of B-cell-associated markers CD20 and CD79a [1,[3][4][5][6]. The high-grade nature of this lymphoma is also represented by numerous interspersed ''tingible-body macrophages'', imparting a starry-sky appearance, and brisk mitotic activity [7].…”

Section: Introductionmentioning

confidence: 99%

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Plasmablastic Lymphoma of Head and Neck: Report of Two New Cases and Correlation with c-myc and IgVH Gene Mutation Status

Hassan

Kreisel

Gardner

et al. 2007

Head and Neck Pathol

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Plasmablastic lymphoma (PBL) is a rare acquired immunodeficiency syndrome-associated nonHodgkin's lymphoma (AIDS-NHL), with predilection for the mucosa of oral cavity. It usually has a plasmablastic morphology, expressing plasma cell-associated antigens with weak or absent expression of B-cell-associated markers. To further define the immunophenotypic and molecular genetics of these tumors, we investigated two cases of plasmablastic lymphomas of the head and neck for c-myc gene rearrangement and immunoglobulin heavy chain (IgV H ) hypermutation status. For the first time we report a case of AIDS-related PBL that, by fluorescence in situ hybridization (FISH), shows a c-myc gene rearrangement. Although current literature suggests that most cases of c-myc gene rearranged AIDS-NHL are Burkitt's lymphoma, our case has an immunophenotype characteristic for PBL. In this case, IgV H hypermutation analysis showed a somatic hypermutation, indicative of germinal center transit. The concurrent B-cell immunophenotype of BCL-6 -/CD138 + /MUM-1 + also suggests a post-germinal center B-cell origin of this lymphoma. The immunophenotype of our second case (BCL-6 -/CD138 + /MUM-1 + ) also suggests a post-germinal center B-cell origin. However, IgV H hypermutation analysis was not possible in this case.

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“…128,129,130 The median age at presentation is approximately 30-50 years. However, a broad age range from 7 to 75 years exists.…”

Section: Epidemiologymentioning

confidence: 99%

Large Cell Lymphoma: Correlation of HIV Status and Prognosis with Differentiation Profiles Assessed by Immunophenotyping

Pather

Mohamed

McLeod

et al. 2013

Pathol. Oncol. Res.

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Oral plasmablastic lymphoma in an HIV-negative patient: A case report and review of the literature

Cited by 70 publications

References 23 publications

Plasmablastic Lymphoma in a Previously Undiagnosed Aids Patient: A Case Report

Plasmablastic Lymphoma in a Previously Undiagnosed Aids Patient: A Case Report

Plasmablastic Lymphoma of Head and Neck: Report of Two New Cases and Correlation with c-myc and IgVH Gene Mutation Status

Large Cell Lymphoma: Correlation of HIV Status and Prognosis with Differentiation Profiles Assessed by Immunophenotyping

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