2017
DOI: 10.1186/s41120-017-0015-8
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Oral solid self-nanoemulsifying drug delivery systems of candesartan citexetil: formulation, characterization and in vitro drug release studies

Abstract: Candesartan cilexetil is an ester prodrug antagonist to angiotensin II receptor type 1 (AT1) used in management of many cardiovascular diseases. The absolute bioavailability of candesartan cilexetil is about (14-40%). Therefore, the paper aim was to prepare and evaluate solid self-nanoemulsifying drug delivery systems for candesartan cilexetil in order to improve its solubility, dissolution and stability. Solubility study was run in different vehicles to select the best excipients for dissolving candesartan ci… Show more

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Cited by 24 publications
(24 citation statements)
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“…For the purpose of topical/transdermal drug delivery, droplet size determines an important aspect of diffusion, as smaller particles tend to portray faster, together with increasingly significant permeation across the SC [111][112][113]. Decreased droplet sizes can be supported by including surfactants that reduce interfacial tension in order to establish the formation of fine droplets [114]. Thus, the lipid-altering potential, along with droplet refinement potential, of surfactants can assist in the successful delivery of topical/transdermal SEDDSs [58,111,112,114].…”
Section: Evaluation Of Droplet Sizes Zeta Potential and Polydispersmentioning
confidence: 99%
See 1 more Smart Citation
“…For the purpose of topical/transdermal drug delivery, droplet size determines an important aspect of diffusion, as smaller particles tend to portray faster, together with increasingly significant permeation across the SC [111][112][113]. Decreased droplet sizes can be supported by including surfactants that reduce interfacial tension in order to establish the formation of fine droplets [114]. Thus, the lipid-altering potential, along with droplet refinement potential, of surfactants can assist in the successful delivery of topical/transdermal SEDDSs [58,111,112,114].…”
Section: Evaluation Of Droplet Sizes Zeta Potential and Polydispersmentioning
confidence: 99%
“…Decreased droplet sizes can be supported by including surfactants that reduce interfacial tension in order to establish the formation of fine droplets [114]. Thus, the lipid-altering potential, along with droplet refinement potential, of surfactants can assist in the successful delivery of topical/transdermal SEDDSs [58,111,112,114]. Likewise, finer droplets comprising lipophilic drugs have demonstrated an increased affinity for subcutaneous lymphatic uptake and could assist in avoiding metabolic processes within the dermis [6,12].…”
Section: Evaluation Of Droplet Sizes Zeta Potential and Polydispersmentioning
confidence: 99%
“…The samples were diluted 100 and 1000 times with water and 0.1 HCl. It was allowed to stand for 24 hours and viewed for any changes such as phase separation or precipitation of drug (Ali and Hussein, 2017).…”
Section: Effect Of Dilutionmentioning
confidence: 99%
“…The hausner's ratio predicts the propensity or lowabilty of a given powder sample to be compressed (Ali and Hussein, 2017). It was determined by the formula…”
Section: Hausner's Ratiomentioning
confidence: 99%
“…To control hypertension Thiazide diuretics, angiotensin-converting enzyme inhibitors, β-blockers, calcium antagonists, and AT1 antagonists are employed mostly to prevent organ damage and reduce the mortality rate. However, most of these undertake extensive first-pass metabolism, frequent administration and have varied bioavailability [5]. The most possible method for increasing dissolution with the help of a water-soluble carrier is to reduce the particle size and thereby increase the surface area of absorption.…”
Section: Introductionmentioning
confidence: 99%