Oral Squamous Cell Carcinoma: Current Treatment Strategies and Nanotechnology-Based Approaches for Prevention and Therapy

Gharat, Sankalp; Momin, Munira; Bhavsar, Chintan

doi:10.1615/critrevtherdrugcarriersyst.2016016272

Cited by 167 publications

(128 citation statements)

References 150 publications

Supporting

Mentioning

124

Contrasting

Unclassified

Order By: Relevance

“…Cur microemulsions were more cytotoxic than a free Cur formulation, and cell viability further decreased with the addition of ultrasound [44]. Mucoadhesive polycaprolactone (PCL) NPs loaded with Cur were also obtained by coating them with chitosan (CS) for local therapy of oral cavity SCC [34,45].These Cur-NPs induced apoptotic death of tongue tumor cells and were less cytotoxic than a free Cur formulation [45].…”

Section: Curcuminmentioning

confidence: 99%

See 1 more Smart Citation

Nanomedicine, an emerging therapeutic strategy for oral cancer therapy

et al. 2018

View full text Add to dashboard Cite

Oral cavity and oropharyngeal carcinomas (oral cancer) represents a significant cause of morbidity and mortality. Despite efforts in improving early diagnosis and treatment, the 5-year survival rate of advanced stage of the disease is less than 63%. The field of nanomedicine has offered promising diagnostic and therapeutic advances in cancer. Indeed, several platforms have been clinically approved for cancer therapy, while other promising systems are undergoing exploration in clinical trials. With its ability to deliver drugs, nucleic acids, and MRI contrast agents with high efficiency, nanomedicine platforms offer the potential to improve drug efficacy and tolerability. The aim of the present mini-review is to summarize the current preclinical status of nanotechnology systems for oral cancer therapy. The nanoplatforms for delivery of chemopreventive agents presented herein resulted in significantly higher anti-tumor activity than free forms of the drug, even against a chemo-resistant cell line. Impressive results have also been obtained using nanoparticles to deliver chemotherapeutics, resulting in reduced toxicity both in vitro and in vivo. Nanoparticles have also led to improvements in efficacy of photodynamic therapies through the development of targeted magnetic nanoparticles. Finally, gene therapy using nanoparticles demonstrated promising results specifically with regards to inhibition of gene expression. Of the few in vivo studies that have been reported, many of these used animal models with several limitations, which will be discussed herein. Lastly, we will discuss several future perspectives in oral cancer nanoparticle-based therapy and the development of appropriate animal models, distinguishing between oral cavity and oropharyngeal carcinoma.

show abstract

Section: Curcuminmentioning

confidence: 99%

“…However, to date, no NP-based treatment has been approved for HNSCC [31,32]. Clinical trials have been performed and other trials are currently underway to treat advanced HNSCC [31,33,34]. As an example, a liposomal Dox (Doxil/Caelix®) was explored in certain instances of HNSCC [33,35,36].…”

mentioning

confidence: 99%

Nanomedicine, an emerging therapeutic strategy for oral cancer therapy

et al. 2018

View full text Add to dashboard Cite

show abstract

“…OSCC is the most prevalent form of cancer worldwide, especially in developing regions such as Southeast China (Gharat et al, ). Several previous studies have suggested a close link between mitochondrial fission and cisplatin sensitivity in OSCC cells (Fan et al, , b; Li et al, ), indicating a role for mitochondrial fission in the progression of OSCC.…”

Section: Discussionmentioning

confidence: 99%

MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production

Xiao

Sun

Xing

et al. 2019

Cell Biology International

View full text Add to dashboard Cite

Mitochondrial fission process 1 (MTFP1) is a novel nuclear‐encoded protein that promotes mitochondrial fission. Increasing lines of evidence indicate that increased mitochondrial fission is involved in carcinogenesis and tumor progression. However, the expression and biological effects of MTFP1 in cancer development is still unclear, especially in oral squamous cell carcinoma (OSCC). In this study, we first evaluated the expression of MTFP1 in 12‐paired OSCC tumor and peritumor tissues. We then explored the effects of MTFP1 knockdown or overexpression on cell growth by cell proliferation, colony formation, cell cycle, and cell apoptosis assays. Furthermore, the mechanisms by which MTFP1 promoted OSCC cell growth were explored. Our results showed that MTFP1 is frequently overexpressed in OSCC tissues. Functional experiments revealed that MTFP1 promoted the growth of OSCC cells by inducing the progression of cell cycle and suppressing cell apoptosis. Mechanistically, MTFP1 overexpression‐mediated mitochondrial fragmentation and subsequent ROS production was found to be involved in the promotion of OSCC cell growth. Collectively, our study demonstrates that MTFP1 plays a critical oncogenic role in OSCC carcinogenesis, which may serve as a potential therapeutic target in the treatment of this malignance.

show abstract

“…As the sixth most prevalent malignancy worldwide, oral cancer is a major global health issue . The most common type of oral cancer, oral squamous cell carcinoma (OSCC), results from an accumulation of multiple genetic mutations that ultimately causes damage to oral epithelial cells . OSCC remains the major cause of head and neck cancer‐associated morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Effect of verbascoside on apoptosis and metastasis in human oral squamous cell carcinoma

Zhang

Yuan

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

Despite significant advances in therapy, the 5-year survival rates for patients with advanced stage oral cancers still remains poor as an appropriate treatment has not been found yet, due to side effects of chemo/radiotherapy. Verbascoside (VB), a major bioactive constituent of the Tsoong herb, displays pharmacological properties by exhibiting anti-oxidative, anti-inflammatory and anti-cancer activities. However, the underlining function and mechanism of VB in human oral squamous cell carcinoma (OSCC) remains unclear. In this study, we show that VB significantly decreased the viability and metastasis of HN4 and HN6 tumor cells, while promoting apoptosis. A xenograft OSCC mouse model further showed that intraperitoneal injection of VB strongly inhibited growth and lung metastasis of implanted tumor cells. Immunoblot analysis confirmed that VB effectively suppressed nuclear factor (NF)-κB activation and downstream Bcl-2/Bcl-XL expression, resulting in increased OSCC cell apoptosis. In addition, VB suppressed mRNA and protein expression of matrix metalloproteinase-9 via suppression of NF-κB activation, thereby inhibiting tumor cell metastasis. Inspiringly, compared to cisplatin-treated group, VB is a biocompatible agent without signficant side effects in vivo. Collectively, our results demonstrate that VB effectively inhibits OSCC tumor cell growth and metastasis via suppression of IκB kinase complex (IKK)/NF-κB-related signaling activation, suggesting that VB has potential use as a potent anticancer agent in OSCC therapeutic strategies.

show abstract

Oral Squamous Cell Carcinoma: Current Treatment Strategies and Nanotechnology-Based Approaches for Prevention and Therapy

Cited by 167 publications

References 150 publications

Nanomedicine, an emerging therapeutic strategy for oral cancer therapy

Nanomedicine, an emerging therapeutic strategy for oral cancer therapy

MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production

Effect of verbascoside on apoptosis and metastasis in human oral squamous cell carcinoma

Contact Info

Product

Resources

About