Oral ulcers caused by hydroxyurea

Paleri, Vinidh; Lindsey, L

doi:10.1258/0022215001904518

Cited by 16 publications

(6 citation statements)

References 8 publications

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“…All reported cases used hydroxyurea for chronic myeloproliferative neoplasm [5-8]. The lesions were confined to the lips, base of tongue and buccal mucosa, and were not related to myelosuppression or cumulative dose.…”

Section: Discussionmentioning

confidence: 99%

“…Other common side effects are gastrointestinal (GI), such as nausea, vomiting, diarrhea, anorexia and stomatitis, as well as cutaneous, such as skin hyperpigmentation, nail changes and alopecia [3,4]. Unusual mucocutaneous side effects are leg and rarely oral ulcers, which may occur after a prolonged use, and are reversible after drug cessation [5-8]. Leukocytoclastic vasculitis was shown in biopsies of leg ulcers from patients with chronic myeloproliferative neoplasm who had been on this drug [9-11].…”

Section: Introductionmentioning

confidence: 99%

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Hydroxyurea and colonic ulcers: a case report

et al. 2014

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BackgroundHydroxyurea at a relatively low dose is frequently prescribed to induce hemoglobin F production in patients with sickle cell and β-thalassemia diseases because of its good efficacy and safety profiles. However, a potentially fatal gastrointestinal ulceration was recently found and herein reported.Case presentationA thirty-seven-year-old man with transfusion dependent hemoglobin E/β-thalassemia disease was treated with hydroxyurea to induce hemoglobin F production since 2007 without incident. From 2008 to April 2010, episodes of hematochezia, mucous diarrhea and epigastric pain intermittently manifested. Four colonoscopies done during the period repeatedly showed ulcerative lesions from the terminal ileum to the ascending colon with a non-specific histo-pathologic finding. Subsequently, ulcerative lesions also developed at the pharynx, histo-pathologic findings of which were not different from those in the colon. These ulcerative lesions resolved within a month after discontinuing hydroxyurea in April 2010 and have not recurred since.ConclusionThe findings suggested role of hydroxyurea in the pathogenesis of these ulcers, and that it must be immediately discontinued to prevent further damage to the digestive mucosa.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydroxyurea and colonic ulcers: a case report

et al. 2014

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“…3 The rate of intolerance to hydroxyurea due to side effects has been reported to be between 5% and 16%. [4][5][6][7][8][9] The oral cavity is by far the commonest site for ulcer formation in the gastrointestinal tract associated with hydroxyurea, [10][11][12][13] and oral ulcers were reported to occur in 0.8% of patients with myeloproliferative neoplasm on hydroxyurea therapy. 8 Ulcers in the other parts of the gastrointestinal tract are exceedingly rare and to our knowledge, there have been only 3 such reported cases as summarized in Table 1.…”

Section: Discussionmentioning

confidence: 99%

Hydroxyurea associated ileocecal valve ulcer: evidence for causality

et al. 2021

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A 73-year-old woman was referred for investigation of unexplained loss of appetite and loss of weight. She had a past medical history of essential thrombocythemia which was positive for JAK2 V617F mutation and was treated with hydroxyurea 1 g daily for 10 years. She was not on any other long-term medication. Her clinical examination was unremarkable apart from the presence of melanonychia. Her full blood count results were as following; hemoglobin of 11.6 g/dL, white cell counts of 5.1 × 10 9 /L and platelet counts of 335 × 10 9 /L. Her biochemical profile, coagulation profile, and serum inflammatory markers were all within normal limits. In view of her symptoms and advanced age, a colonoscopy was performed. The colonoscopy showed a clean based ulcer measuring 2.5 cm on the ileocecal valve (ICV), with normal mucosa in the terminal ileum and colon (Fig. 1). Histopathological assessment of the biopsies taken from the ulcer edge was consistent with active colitis and ulcerations with no diagnostic features

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“…Sie sind meist schmerzhaft, fibrinbelegt, haben einen atrophischen Rand und sind durch eine ausgeprägte Therapieresistenz gekennzeichnet. Orale Ulzera sind eher selten [20]. In Einzelfällen wurden Ulzerationen auch genital [16], postoperativ [30] und an den Handrücken [12] beschrieben.…”

Section: Diskussionunclassified

Ulzerationen unter Therapie mit Hydroxyharnstoff

Boneberger

Rupec

Ruzicka³

2009

Hautarzt

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Hydroxyurea is frequently used for therapy of myeloproliferative disorders. One cutaneous side-effect is painful, therapy-resistant ulcers which have bizarre configurations and occur at atypical sites for venous ulcers. Improvement or healing often first occurs when hydroxyurea is discontinued. We report on one patient with essential thrombocythemia and two with polycythemia vera, who developed such ulcers during hydroxyurea therapy. In one case, the ulcers developed shortly after hydroxyurea was started. In addition we give a short overview of the current literature.

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Oral ulcers caused by hydroxyurea

Cited by 16 publications

References 8 publications

Hydroxyurea and colonic ulcers: a case report

Hydroxyurea and colonic ulcers: a case report

Hydroxyurea associated ileocecal valve ulcer: evidence for causality

Ulzerationen unter Therapie mit Hydroxyharnstoff

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