OralCandida albicans in bone marrow transplant patients given chlorhexidine rinses: Occurrence and susceptibilities to the agent

Thurmond, Jennifer M.; Brown, Albert T.; Sims, R.; Ferretti, Gerald A.; Raybould, Ted P.; Lillich, Thomas T.; Henslee, P. Jean

doi:10.1016/0030-4220(91)90217-z

Cited by 35 publications

(15 citation statements)

References 20 publications

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“…Numerous studies have investigated the immediate effects of chemotherapy and/or radiation on the oral mucosa and other perioral soft tissues, [1][2][3][4][5][6][7][8][9][10][11][12] but few have addressed late dental sequelae of cancer treatment received at an early age. Nasam, 13 Kaste et al [14][15][16] observed hypodontia, microdontia, enamel hypoplasia, root stunting, taurodontia, over-retention of primary teeth, and an increased caries index in survivors of childhood cancer.…”

Section: Discussionmentioning

confidence: 99%

Dental abnormalities in children preparing for pediatric bone marrow transplantation

Vaughan

Rowland

Tong

et al. 2005

Bone Marrow Transplant

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Summary:The purpose of our study was to describe the types and frequencies of altered dental development in pediatric patients preparing for bone marrow transplantation (BMT). Retrospective review of the medical records and panoramic radiographs of all patients who underwent BMT at St Jude Children's Research Hospital between 1990 and 2000 for whom pre-BMT dental examination and panoramic radiography records were available. All patients were treated on institutional protocols. We recorded patient demographics and radiographic evidence of microdontia, hypodontia, taurodontia, root stunting, caries, enamel pearls, and pulpal calcifications. The 259 patients identified (150 male and 109 female) had a median age of 12.82 years (range, 3.18-25.93 years) at the time of BMT. In total, 203 were Caucasian, 38 were African-American, and 18 were of other races. In all, 150 (57.9%) had abnormal dentition. The most common dental abnormalities were caries (n ¼ 84), pulpal calcifications (n ¼ 34), and dental extractions (n ¼ 33). Developmental abnormalities occurred less frequently: taurodontia (n ¼ 8), hypodontia (n ¼ 10), microdontia (n ¼ 11), and root stunting (n ¼ 11). Dental abnormalities are prevalent in children undergoing BMT. Pre-transplant oral hygiene and dental examination should be standard care in order to minimize potential sites of infection.

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Section: Discussionmentioning

confidence: 99%

Dental abnormalities in children preparing for pediatric bone marrow transplantation

Vaughan

Rowland

Tong

et al. 2005

Bone Marrow Transplant

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“…However, an MFC was not achieved with Dentosan S against C. parapsilosis and C. guilliermondii. 26 However, according to the criteria of Slots et al,39 some of the tested strains could be considered resistant, because MFCs were higher than 70 µg/ml. Furthermore, no significant differences were found in MFC values of CHX mouthrinse products, once adjusted for initial concentration differences of CHX (Table 3).…”

Section: Mouthrinsesmentioning

confidence: 99%

In Vitro Antifungal Properties of Mouthrinses Containing Antimicrobial Agents

Giuliana

Pizzo

Milici

et al. 1997

Journal of Periodontology

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The purpose of this study was to investigate the in vitro antifungal properties of seven commercial mouthrinses containing antimicrobial agents. These included cetylpyridinium chloride (CPC), chlorhexidine digluconate (CHX), hexetidine (HEX), sanguinarine (SNG), and triclosan (TRN). The minimum fungicidal concentration (MFC) against six species of yeasts was determined by a broth macrodilution method. The kill-time of mouthrinses at half the concentration of the commercial formulations was also determined. MFCs were achieved with each mouthrinse, except the SNG-containing mouthrinse, against all the organisms being tested. However, the CPC-containing mouthrinse appeared more active than the other products (P < 0.001). There were no significant differences in MFC values among CHX mouthrinse products, once adjusted for initial concentration differences (P = 0.1). Kill-times of mouthrinses containing either CHX or CPC were less than or equal to 180 seconds with all the species of yeasts, and no significant differences were found among these products (P = 0.18). On the other hand, mouthrinses containing either TRN or HEX did not show a lethal effect on Candida albicans, Candida parapsilosis, or Candida guilliermondii. No kill-times were achieved with the SNG-containing mouthrinse. These results suggest that mouthrinses containing antimicrobial agents might represent an appropriate alternative to conventional antifungal drugs in the management of oral candidiasis. However, the effectiveness of antimicrobial mouthrinses as antifungal agents needs to be evaluated in further clinical trials.

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“…other than C. albicans, such as C. glabrata, Candida tropicalis and C. krusei [13,17]. It has also been shown to have superior efficacy against Candida biofilms compared with FLZ in vitro and in vivo [13,[18][19][20][21]. Furthermore, it can be used to impregnate denture liners to act as a long-term self-release drug carrier [22].…”

Section: Introductionmentioning

confidence: 97%

Chlorhexidine is a highly effective topical broad-spectrum agent against Candida spp.

Salim

Moore

Silikas

et al. 2013

International Journal of Antimicrobial Agents

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OralCandida albicans in bone marrow transplant patients given chlorhexidine rinses: Occurrence and susceptibilities to the agent

Cited by 35 publications

References 20 publications

Dental abnormalities in children preparing for pediatric bone marrow transplantation

Dental abnormalities in children preparing for pediatric bone marrow transplantation

In Vitro Antifungal Properties of Mouthrinses Containing Antimicrobial Agents

Chlorhexidine is a highly effective topical broad-spectrum agent against Candida spp.

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