Pharmaceutical Biotechnology
DOI: 10.1007/0-306-47384-4_22
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Orally Active Nonpeptide CCK-A Agonists

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Cited by 9 publications
(6 citation statements)
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“…Temperature coefficients were obtained from least-squares fits to data of 30, 35, 40, 45, 50, 55, and 60 °C in DMSO-d6. 13 C NMR spectra were recorded with a Varian Gemini-200 operating at 50 MHz. Elemental analyses were obtained on a CH-O-RAPID apparatus.…”
Section: Methodsmentioning
confidence: 99%
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“…Temperature coefficients were obtained from least-squares fits to data of 30, 35, 40, 45, 50, 55, and 60 °C in DMSO-d6. 13 C NMR spectra were recorded with a Varian Gemini-200 operating at 50 MHz. Elemental analyses were obtained on a CH-O-RAPID apparatus.…”
Section: Methodsmentioning
confidence: 99%
“…This potentiality has prompted an intensive research in this area, and several potent and selective nonpeptide CCK 1 and CCK 2 receptor agonists and antagonists have been reported over the past decade. [11][12][13][14][15] Among these compounds, dipeptoids were designed from structure-activity relationship studies on the endogenous CCK 2 receptor-selective agonist CCK-4 (H-Trp 30 -Met 31 -Asp 32 -Phe 33 -NH 2 ), which revealed the importance of the aromatic side-chains of Trp and Phe residues as key binding fragments. [16][17][18] Both CCK 1 and CCK 2 receptor-selective antagonists were obtained within this structural family of compounds.…”
Section: Introductionmentioning
confidence: 99%
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“…In the gastrointestinal tract, CCK is involved in a number of physiological processes including gall bladder contractions, pepsinogen secretion, pancreatic amylase secretion, inhibition of gastric emptying, and decreased small bowl and increased colonic transit times, whereas in the central nervous system CCK effectuates satiety, anxiety, memory, and analgesia (1)(2)(3)(4)(5). CCK is released into the blood and into the synaptic space of neurons in response to stimulation by nutriment in the gastrointestinal tract; therefore, the CCK A receptor subtype is an attractive target for the development of pharmaceutically driven therapies for the treatment of obesity (6).…”
mentioning
confidence: 99%