Orally Administered Liposomes Prepared with Egg Phosphatidylcholine and Stearylamine: Possible Destruction in Rat Intestinal Wall

Abstract

Sir, Dr. Fukunaga and colleagues have observed that liposome-entrapped calcitonin administered orally to fasting male rats resulted in a light hypocalcemia when the phospholipids layers contained stearylamine (Fukunaga, Miller and Deftos 1991). However, even with this improvement, the hypocalcemia measured was much lighter than when the hormone was injected (Dupuy, Peuchant, Vitiello, Jensen, Baghdiantz and Blanquet 1983; Dupuy 1983). The advantage in oral administration of this peptide led us to examine why it was inefficient.