Orally administered octacosanol improves some features of high fructose-induced metabolic syndrome in rats

Abstract

We examined whether orally administered octacosanol, a long chain aliphatic saturated alcohol, improves the features of high fructose induced metabolic syndrome in rats. Five week old rats were fed a high fructose diet containing 60% fructose for 3 weeks. Then, the high fructose fed rats received a daily single oral administration of octacosanol (10 or 100 mg/kg body weight) with high fructose feeding for one week. Three or four week high fructose feeding increased insulin resistance, serum insulin, triglyceride, total cholesterol, free fatty acids, uric acid, and lipid peroxide concentrations, and hepatic triglyceride and cholesterol contents significantly and decreased serum high density lipopro tein cholesterol and adiponectin concentrations significantly but did not affect blood pressure and hepatic lipid peroxide and reduced glutathione contents. Four week high fructose feeding decreased hepatic ascorbic acid content significantly. Oral admin istration of octacosanol (10 or 50 mg/kg body weight) to high fructose fed rats for the last 1 week fructose diet feeding attenuated these changes except serum insulin level and insulin resistance significantly and increased hepatic reduced glutathione content significantly. The higher dose of Oct decreased hepatic lipid peroxide content significantly. These results indicate that orally administered octacosanol improves dyslipidemia, hyperuricemia, hypoadiponectinemia, and oxidative stress associated with the features of high fructose induced metabolic syndrome rats.

Fructose Consumption Causes Cell Death through ER Stress in Pancreas and Changes Biochemical Parameters in Blood

“…On the contrary, Ramos et al [17] showed that fructose consumption in different periods increased liquid intake and reduced food intake but the body weight did not change. Moreover, Oashi et al [18] found that there was no significant difference in body weight of rats fed high-fructose diet (60% fructose) for 3 or 4 weeks compared to rats fed control diet. Similar to the above studies, food and liquid intake in the fructose-fed rats were inversely altered, while body weights were the same in the present study.…”

Maternal high-fructose consumption provokes placental oxidative stress resulting in asymmetrical fetal growth restriction in rats

“…( 18 ) Additionally, fructose induces de novo UA synthesis, which can aggravate oxidative stress. ( 19 , 20 ) Accordingly, we performed the present animal study to investigate the effect of maternal high-fructose consumption during pregnancy on placental oxidative stress and fetal growth.…”

Acute effect of fructose, sucrose, and isomaltulose on uric acid metabolism in healthy participants

“…(9) In addition, octacosanol, which is a long-chain aliphatic saturated alcohol, decreased serum UA concentrations. (10) However, whether isomaltulose, which is the structural isomers of sucrose found in honey, (11,12) affects serum concentration and urinary excretion of UA, is still uncertain.…”