Orally administrable polyphenol-based nanoparticles achieve anti-inflammation and antitumor treatment of colon diseases

Le, Zhicheng; He, Zepeng; Liu, Hong; Ke, Jia; Liu, Lixin; Liu, Zhijia; Chen, Yongming

doi:10.1039/d2bm00540a

Cited by 11 publications

(4 citation statements)

References 54 publications

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“…These nanoparticles also demonstrated anti-cancer activity showed by reducing tumour size in azoxymethane (AOM)/dextran sulphate sodium (DSS)-induced C57/BL6 mice after therapy. Moreover, this study confirmed that encapsulation in a polyphenol carrier improved therapeutic efficacy and provided a safe and effective nanoplatform for the polyphenolic compound [75].…”

Section: Crcsupporting

confidence: 72%

Encapsulation of Polyphenolic Compounds Based on Hemicelluloses to Enhance Treatment of Inflammatory Bowel Diseases and Colorectal Cancer

Caban

Lewandowska

2023

Molecules

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Inflammatory bowel diseases (IBD) and colorectal cancer (CRC) are difficult to cure, and available treatment is associated with troubling side effects. In addition, current therapies have limited efficacy and are characterized by high costs, and a large segment of the IBD and CRC patients are refractive to the treatment. Moreover, presently used anti-IBD therapies in the clinics are primarily aimed on the symptomatic control. That is why new agents with therapeutic potential against IBD and CRC are required. Currently, polyphenols have received great attention in the pharmaceutical industry and in medicine due to their health-promoting properties. They may exert anti-inflammatory, anti-oxidative, and anti-cancer activity, via inhibiting production of pro-inflammatory cytokines and enzymes or factors associated with carcinogenesis (e.g., matrix metalloproteinases, vascular endothelial growth factor), suggesting they may have therapeutic potential against IBD and CRC. However, their use is limited under both processing conditions or gastrointestinal interactions, reducing their stability and hence their bioaccessibility and bioavailability. Therefore, there is a need for more effective carriers that could be used for encapsulation of polyphenolic compounds. In recent years, natural polysaccharides have been proposed for creating carriers used in the synthesis of polyphenol encapsulates. Among these, hemicelluloses are particularly noteworthy, being characterized by good biocompatibility, biodegradation, low immunogenicity, and pro-health activity. They may also demonstrate synergy with the polyphenol payload. This review discusses the utility and potential of hemicellulose-based encapsulations of polyphenols as support for treatment of IBD and CRC.

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Section: Crcsupporting

confidence: 72%

Encapsulation of Polyphenolic Compounds Based on Hemicelluloses to Enhance Treatment of Inflammatory Bowel Diseases and Colorectal Cancer

Caban

Lewandowska

2023

Molecules

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“…In addition, scaffolds are expected to modulate the immunoreaction and promote a pro-regenerative microenvironment when appropriately designed and clinically translated . TA, rich in phenolic hydroxyls, has been extensively studied as an anti-inflammatory agent, and numerous studies have confirmed that scaffolds modified with TA possess potent anti-inflammation ability. , In this study, we explored how the scaffold modulated macrophage polarization and alleviated inflammation. The DTS-TA 0.1 group had more M2 macrophages, higher expression of IL-4, and significantly decreased levels of IL-6 and IL-1β than the DTS group, which possessed a better anti-inflammatory effect than the control group.…”

Section: Resultsmentioning

confidence: 99%

Tannic Acid-Modified Decellularized Tendon Scaffold with Antioxidant and Anti-Inflammatory Activities for Tendon Regeneration

Zhao,

Luo,

Cui

et al. 2024

ACS Appl. Mater. Interfaces

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Tendon regeneration is greatly influenced by the oxidant and the inflammatory microenvironment. Persistent inflammation during the tendon repair can cause matrix degradation, tendon adhesion, and excessive accumulation of reactive oxygen species (ROS), while excessive ROS affect extracellular matrix remodeling and tendon integration. Herein, we used tannic acid (TA) to modify a decellularized tendon slice (DTS) to fabricate a functional scaffold (DTS-TA) with antioxidant and anti-inflammatory properties for tendon repair. The characterizations and cytocompatibility of the scaffolds were examined in vitro. The antioxidant and anti-inflammatory activities of the scaffold were evaluated in vitro and further studied in vivo using a subcutaneous implantation model. It was found that the modified DTS combined with TA via hydrogen bonds and covalent bonds, and the hydrophilicity, thermal stability, biodegradability, and mechanical characteristics of the scaffold were significantly improved. Afterward, the results demonstrated that DTS-TA could effectively reduce inflammation by increasing the M2/M1 macrophage ratio and interleukin-4 (IL-4) expression, decreasing the secretion of interleukin-6 (IL-6) and interleukin-1β (IL-1β), as well as scavenging excessive ROS in vitro and in vivo. In summary, DTS modified with TA provides a potential versatile scaffold for tendon regeneration.

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“…These nanoparticles exhibited antioxidant and anti-inflammatory function by ROS scavenging and provided a safe and effective tannic acid-containing nanoplatform for the prevention and treatment of for acute lung injury and colon diseases. [58,59] Through aqueous self-assembly, poly (ethylene glycol) (PEG) containing polymers DSPE-PEG2k can be captured by TA through hydrogen bonding and then the supramolecular nanoparticles were constructed for the protective delivery of infliximab. Then, a significantly enhanced therapeutic efficacy in IBD treatment can be achieved compared to the free infliximab through orally delivery.…”

Section: Ta-mediated Supramolecular Self-assembly Ddssmentioning

confidence: 99%

Advances of natural polyphenol based anti-oxidant nanomaterials for efficient treatment of inflammatory bowel disease

Wang,

Yang,

et al. 2023

Preprint

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Excessive generation of reactive oxygen species (ROS) resulting in oxidative stress and plays a crucial role in the progression of inflammatory bowel disease (IBD), which may in turn serve as a potential therapeutic target. To date, efforts on ROS scavenging systems have been focused predominantly on metal oxide nanoenzymes and polyphenol-based nanomaterials. Polyphenols, as a natural plant extract, have attracted increasing interests and showed great antioxidant properties in IBD therapy. The unique catechol groups in polyphenols allowing them to interact with biomolecules, such as proteins and nucleic acids. Additionally, the strong metal ion chelating ability of catechol enriched the structure and function of nanomaterials. This characteristic not only improves the physicochemical properties of polyphenols based nano-carriers but also enables innovative designs of multifunctional drug delivery systems (DDSs). To date, research on polyphenol-based DDSs has increased, including epigallocatechin gallate (EGCG), curcumin (CUR), resveratrol, tannic acid (TA), rosmarinic acid (RA) and dopamine (DA). In this review, we mainly focus on the design and application of natural polyphenol based nanomaterials in IBD, providing a comprehensive discussion on the use of polyphenols in DDSs. We will also discuss the potential challenges in innovative drug delivery strategies, including their impact on the physical and chemical properties of drug delivery systems.

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Orally administrable polyphenol-based nanoparticles achieve anti-inflammation and antitumor treatment of colon diseases

Abstract: Colorectal cancer is the third most common malignancy that leads to significant mortality around the world. Chronic colonic inflammation could induce a protumor effect by the massive release of pro-inflammatory...

Cited by 11 publications

References 54 publications

Encapsulation of Polyphenolic Compounds Based on Hemicelluloses to Enhance Treatment of Inflammatory Bowel Diseases and Colorectal Cancer

Encapsulation of Polyphenolic Compounds Based on Hemicelluloses to Enhance Treatment of Inflammatory Bowel Diseases and Colorectal Cancer

Tannic Acid-Modified Decellularized Tendon Scaffold with Antioxidant and Anti-Inflammatory Activities for Tendon Regeneration

Advances of natural polyphenol based anti-oxidant nanomaterials for efficient treatment of inflammatory bowel disease

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