Orally delivered solid lipid nanoparticles of irinotecan coupled with chitosan surface modification to treat colon cancer: Preparation, in-vitro and in-vivo evaluations

Bhaskaran, Navya Ajitkumar; Jitta, Srinivas Reddy; Salwa, -; Cheruku, SriPragnya; Kumar, Nitesh; Kumar, Lalit

doi:10.1016/j.ijbiomac.2022.05.060

Cited by 32 publications

(12 citation statements)

References 48 publications

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“…Comparable results were obtained in one study, where the zeta potential of the SLN formulation was significantly increased with increasing the concentration of sodium lauryl sulphate. Authors explained this result based on that anionic surfactants like SLS get adsorbed to the Helmholtz layer of SLN, thereby impart charge to the particle ( Bhaskaran et al, 2022 ). A high zeta potential values; −51.5 and + 58.3 were reported for OZ-loaded SLNs using the ionic surfactants: SDS (anionic) and Cetylpyridinium chloride (cationic), respectively.…”

Section: Discussionmentioning

confidence: 99%

Solid lipid Lyo-Nanosuspension: A promising stabilized oral delivery system for the antihyperglycemic extract of mistletoe Plicosepalus acacia

Alshawwa

Labib

Badr-Eldin

et al. 2023

Saudi Pharmaceutical Journal

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Section: Discussionmentioning

confidence: 99%

Solid lipid Lyo-Nanosuspension: A promising stabilized oral delivery system for the antihyperglycemic extract of mistletoe Plicosepalus acacia

Alshawwa

Labib

Badr-Eldin

et al. 2023

Saudi Pharmaceutical Journal

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“…This may be because free DOX can diffuse into cells through the plasma membrane and intercalate with DNA to induce apoptosis, whereas DOXloaded polymeric micelles can only enter cells through endocytosis due to their large particulate size. 37 In addition, the intensity of red fluorescence originated from the cytoplasm of cells incubated with FA-GC-PBA/DOX was much stronger than that incubated with GC-PBA/DOX (Figure 4B), possibly due to the specific cellular uptake enhanced by the folate ligand on the micelle surface via the active FR-mediated endocytosis, 38,39 as illustrated in Figure 1B. As control, HepG2 cells were first incubated with an excess of folate for 4 h to interrupt the interaction between FA−receptor on the cell surface and folate on the micelle surface and then incubated with DOXloaded polymeric micelles for another 3 h. The results showed no significant difference in the fluorescence intensity between FA-GC-PBA/DOX and GC-PBA/DOX (Figure 4C,D), indicating that the internalization of FA-GC-PBA/DOX via active FR-mediated endocytosis was inhibited by the preincubation of excess folate.…”

Section: 4mentioning

confidence: 99%

Folate-Modified pH and ROS Dual-Responsive Polymeric Nanocarriers for Targeted Anticancer Drug Delivery

Dai,

Chen,

Zhang

et al. 2024

ACS Appl. Nano Mater.

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The tumor microenvironment is distinguished from normal tissues, such as the acidic microenvironment, elevated reactive oxygen species (ROS) levels, and overexpressed specific receptors on the cell surface. According to these unique hallmarks of cancer, stimulus-responsive drug carriers can be designed for targeted anticancer drug delivery and specific drug release in tumor tissues. Herein, a folate-modified pH/ROS dual-responsive polymeric micellar nanosystem was developed for the targeted delivery of doxorubicin (DOX). The drug release profile suggested a sustained drug release from the polymeric micelles and an accelerated drug release at lower pH and higher ROS levels. The cellular uptake assay indicated that the polymeric micelles were internalized by HepG2 cells and that the cellular uptake of micelles can be enhanced by folate modification through a receptor-mediated endocytosis pathway. Furthermore, the folate-modified pH/ ROS dual-responsive polymeric micellar nanocarriers demonstrated enhanced inhibition on the migration of HepG2 cells in the cell scratch test and showed improved suppression on the proliferation of HepG2 cells and a lower IC 50 than the nonfolate micelles in the cell viability test, indicating the desirable in vitro anticancer efficiency of the nanosystem.

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“… 65 LNPs are highly flexible in surface modification, allowing for chemical modifications or functionalization of their outer layer using surface modifiers to impart specific properties or functions to the NPs. 66 , 67 Therefore, medications based on LNPs have superior pharmacokinetic properties, higher bioavailability, lower toxicity, fewer adverse effects, and more accumulation at the target site in vivo. 68 – 71 …”

Section: Advanced Nanotechnologiesmentioning

confidence: 99%

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Huang,

Guo,

et al. 2024

Sig Transduct Target Ther

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Inflammation-associated diseases encompass a range of infectious diseases and non-infectious inflammatory diseases, which continuously pose one of the most serious threats to human health, attributed to factors such as the emergence of new pathogens, increasing drug resistance, changes in living environments and lifestyles, and the aging population. Despite rapid advancements in mechanistic research and drug development for these diseases, current treatments often have limited efficacy and notable side effects, necessitating the development of more effective and targeted anti-inflammatory therapies. In recent years, the rapid development of nanotechnology has provided crucial technological support for the prevention, treatment, and detection of inflammation-associated diseases. Various types of nanoparticles (NPs) play significant roles, serving as vaccine vehicles to enhance immunogenicity and as drug carriers to improve targeting and bioavailability. NPs can also directly combat pathogens and inflammation. In addition, nanotechnology has facilitated the development of biosensors for pathogen detection and imaging techniques for inflammatory diseases. This review categorizes and characterizes different types of NPs, summarizes their applications in the prevention, treatment, and detection of infectious and inflammatory diseases. It also discusses the challenges associated with clinical translation in this field and explores the latest developments and prospects. In conclusion, nanotechnology opens up new possibilities for the comprehensive management of infectious and inflammatory diseases.

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Orally delivered solid lipid nanoparticles of irinotecan coupled with chitosan surface modification to treat colon cancer: Preparation, in-vitro and in-vivo evaluations

Cited by 32 publications

References 48 publications

Solid lipid Lyo-Nanosuspension: A promising stabilized oral delivery system for the antihyperglycemic extract of mistletoe Plicosepalus acacia

Solid lipid Lyo-Nanosuspension: A promising stabilized oral delivery system for the antihyperglycemic extract of mistletoe Plicosepalus acacia

Folate-Modified pH and ROS Dual-Responsive Polymeric Nanocarriers for Targeted Anticancer Drug Delivery

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

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