Orange-red to NIR emissive carbon dots for antimicrobial, bioimaging and bacteria diagnosis

Su, Rixiang; Yan, Hongjun; Jiang, Xiantao; Zhang, Ying; Li, Peiyuan; Su, Wei

doi:10.1039/d1tb02457d

Cited by 48 publications

(22 citation statements)

References 62 publications

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“…Additionally, many natural animal or vegetable derivatives can be used as precursors to prepare CDs [ 17 ]. Generally, as the rich carbon sources for bottom-up preparation, hydrothermal/solvothermal method [ 25 , 38 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ], microwave synthesis [ 51 ], microwave-assisted hydrothermal method [ 52 ], and solvent-free carbonization [ 53 ] are commonly used to treat precursors. Compared to the top-down method, bottom-up treatment has relatively mild conditions and richer sources of raw materials.…”

Section: Preparation Of Pncdsmentioning

confidence: 99%

Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy

et al. 2023

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Photodynamic therapy (PDT) is a treatment that employs exogenously produced reactive oxygen species (ROS) to kill cancer cells. ROS are generated from the interaction of excited-state photosensitizers (PSs) or photosensitizing agents with molecular oxygen. Novel PSs with high ROS generation efficiency is essential and highly required for cancer photodynamic therapy. Carbon dots (CDs), the rising star of carbon-based nanomaterial family, have shown great potential in cancer PDT benefiting from their excellent photoactivity, luminescence properties, low price, and biocompatibility. In recent years, photoactive near-infrared CDs (PNCDs) have attracted increasing interest in this field due to their deep therapeutic tissue penetration, superior imaging performance, excellent photoactivity, and photostability. In this review, we review recent progress in the designs, fabrication, and applications of PNCDs in cancer PDT. We also provide insights of future directions in accelerating the clinical progress of PNCDs.

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Section: Preparation Of Pncdsmentioning

confidence: 99%

Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy

et al. 2023

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“…Cur-NRCQDs can inactivate 100% Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) under xenon lamp irradiation at concentrations of 10 and 15 M, respectively. The reactive oxygen created by Cur-NRCQDs during photodynamic therapy may have disrupted the cell membrane, leading to leakage of the contents [ 153 ]. Lin et al [ 154 ] prepared nanosized, spherical, neutral charge, fluorescent carbon dots with good water dispersibility using fish, ginger, onion, and garlic as carbon sources.…”

Section: Applications Of Cdsmentioning

confidence: 99%

Recent Advances in Synthesis, Modification, Characterization, and Applications of Carbon Dots

Pundi

Chang

2022

Polymers

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Although there is significant progress in the research of carbon dots (CDs), some challenges such as difficulty in large-scale synthesis, complicated purification, low quantum yield, ambiguity in structure-property correlation, electronic structures, and photophysics are still major obstacles that hinder the commercial use of CDs. Recent advances in synthesis, modification, characterization, and applications of CDs are summarized in this review. We illustrate some examples to correlate process parameters, structures, compositions, properties, and performances of CDs-based materials. The advances in the synthesis approach, purification methods, and modification/doping methods for the synthesis of CDs are also presented. Moreover, some examples of the kilogram-scale fabrication of CDs are given. The properties and performance of CDs can be tuned by some synthesis parameters, such as the incubation time and precursor ratio, the laser pulse width, and the average molar mass of the polymeric precursor. Surface passivation also has a significant influence on the particle sizes of CDs. Moreover, some factors affect the properties and performance of CDs, such as the polarity-sensitive fluorescence effect and concentration-dependent multicolor luminescence, together with the size and surface states of CDs. The synchrotron near-edge X-ray absorption fine structure (NEXAFS) test has been proved to be a useful tool to explore the correlation among structural features, photophysics, and emission performance of CDs. Recent advances of CDs in bioimaging, sensing, therapy, energy, fertilizer, separation, security authentication, food packing, flame retardant, and co-catalyst for environmental remediation applications were reviewed in this article. Furthermore, the roles of CDs, doped CDs, and their composites in these applications were also demonstrated.

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“…Overall, this system was found to be a useful tool for antimicrobial photodynamic therapy treatment followed by fluorescent bioimaging. [ 21 ] Researchers developed this method for the early detection of antigen CA‐125, which plays a major role in malign cancers. The simple solvothermal method is used for the development of fluorescent QDs that identify the CA‐125 antigen in the ovarian cancer patient's serum.…”

Section: Diagnosis Using Qdsmentioning

confidence: 99%

Quantum dots in the biomedical world: A smart advanced nanocarrier for multiple venues application

Singh

Raina

Rishipathak³

et al. 2022

Archiv der Pharmazie

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Quantum dots (QDs) are semiconducting nanoparticles having different optical and electrical properties when compared to larger particles. They exhibit photoluminescence when irradiated with ultraviolet light, which is due to the transition of an excited electron from the valence band to the conductance band followed by the return of the exciting electron back into the valence band. The size and material of QDs can affect their optical and other properties too. The QDs possess special attributes like high brightness, protection from photobleaching, photostability, color tunability, low toxicity, low production cost, a multiplexing limit, and a high surfaceto-volume proportion, which make them a promising tool for biomedical applications. Here, in this study, we summarize the utilization of QDs in different applications including bioimaging, diagnostics, immunostaining, single-cell analysis, drug delivery, and protein detection. Moreover, we discuss the advantages and challenges of using QDs in biomedical applications when compared with other conventional tools.

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Orange-red to NIR emissive carbon dots for antimicrobial, bioimaging and bacteria diagnosis

Abstract: Schematic illustration of the preparation of Cur-NRCQDs with orange-red to NIR fluorescence. The Cur-NRCQDs showed excellent antibacterial effects on S. aureus and E.coli under PDT and have imaging applications.

Cited by 48 publications

References 62 publications

Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy

Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy

Recent Advances in Synthesis, Modification, Characterization, and Applications of Carbon Dots

Quantum dots in the biomedical world: A smart advanced nanocarrier for multiple venues application

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