Orbital blood flow parameters in unilateral pseudoexfoliation syndrome

Abstract

These findings suggest that ophthalmic artery hemodynamic parameters change in both eyes of unilateral XFS patients, illustrating out the systemic nature of the disease. We conclude that XFS decreases OA blood flow velocities and increases vascular resistance through progressive build-up.

Ischemic Changes in a Case of Unilateral Pseudoexfoliation Syndrome

“…Similar results were obtained by Yüksel et al [4] We have suggested a value of 0.72 for RI to be the cut-off value for differentiation of PXS. The case in discussion had a left ophthalmic artery RI of 0.88 which is far above what we had reported for the unilateral PXS [5]. We believe that the attenuated retinal vessels and pale optic disc seen on the left fundus are a reflection of increased vascular resistance in the ophthalmic artery due to buildup of pseudoexfoliative material in vessel walls.…”

“…We have previously shown that in unilateral PXS, the affected side has significantly higher mean ophthalmic artery RI (mean ± SD, 95% CI; 0.74 ± 0.04 cm/s, 0.72-0.75) compared to age-sex matched controls (0.69 ± 0.07 cm/s, 0.66-0.72; p=0.009) [5]. Similar results were obtained by Yüksel et al [4] We have suggested a value of 0.72 for RI to be the cut-off value for differentiation of PXS.…”

“…Accumulation of pseudoexfoliative material in iridial vessel walls is associated with increased permeability, narrowing, and finally obstruction [2]. Increased ophthalmic artery resistivity index (RI) in pseudoxfoliation have been reported by two independent studies [4,5]. Saatçi et al found presence of pseudoexfoliative material as a likely risk factor for retinal vein occlusion [6].…”

Pseudoexfoliation and Blood Flow Abnormalities

“…24 Dayanir et al studied the ocular blood flow changes in patients with unilateral pseudoexfoliation syndrome between eyes clinically affected by pseudoexfoliation syndrome versus clinically unaffected eyes and controls. 46 In eyes affected by pseudoexfoliation material, the ophthalmic artery experienced decreases in the peak systolic and end diastolic velocities and increases in the resistive index compared to the control group. Moreover, comparison of the clinically unaffected eyes with the control group showed significant decreases in mean peak systolic velocity by 23% and in end diastolic velocity by 40% of the ophthalmic artery.…”

Evaluation of Choroidal Thickness in Patients with Pseudoexfoliation Syndrome

“…4 Literatürde PEX sendromunun azalmış oküler kan akımı ve iskemik oftalmik hastalıklar ile ilişkili bulunmuştur. [5][6][7] PEX sendromunun santral retinal ven oklüzyonu için risk faktörü olduğu bilinmektedir. 8 Son yıllarda, spektral domain optik koherans tomografi [spectral domain optical coherence tomography (SD-OCT)] ile ilgili gelişmeler koroid kalınlığını in vivo olarak ölçme imkânı sağlamış-tır.…”