Orbital exenteration for advanced periorbital skin cancers: 20 years experience

Nassab, Reza; Thomas, Susan; Murray, D.S.

doi:10.1016/j.bjps.2007.02.012

Cited by 84 publications

(69 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…When clinically appropriate, selecting surgical reconstruction techniques, such as split thickness skin grafts, that do not impair the ability to detect recurrence may be advantageous. 36 For patients with periorbital BCC and cutaneous SCC who are not surgical candidates due to unresectable disease, multifocal malignancies, multiple medical comorbities, or for whom orbital exenteration is not accepted, targeted systemic therapy is another treatment option which warrants consideration as well as further investigation. Vismodegib (Erivedge), a hedgehog pathway inhibitor approved by for the treatment of metastatic and locally advanced BCC, has been shown to produce either a complete or partial response in 30-60 percent of patients with metastatic or locally advanced BCC, 37 and has also been used as neoadjuvant therapy for patients with orbital invasion to make globe-sparing surgical resection possible.…”

Section: Discussionmentioning

confidence: 99%

Orbital exenteration for advanced periorbital non-melanoma skin cancer: prognostic factors and survival

Gerring

Ott

Curry

et al. 2016

Eye

View full text Add to dashboard Cite

Purpose To describe prognostic factors and survival outcomes in patients who underwent orbital exenteration for periocular nonmelanoma cutaneous malignancies. Methods The authors performed an institutional review board-approved retrospective review of all patients who underwent orbital exenteration for nonmelanoma periocular cutaneous malignancies at a tertiary care hospital system over a 10-year period. Patient demographics, tumor, and treatment data were recorded. Survival outcomes included disease-free survival (DFS) and overall survival (OS). Log-rank tests were used to test for difference in survival curves among various potential prognostic indicators, and multivariate analysis was performed using Cox's proportional hazards model. Results Forty-nine patients with an average age of 70.3 years were followed with a median follow-up of 17.5 months. At 2 years the OS was 78% while the DFS was 61%. The mean DFS for basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and sebaceous gland carcinoma (SGC) were 52.6, 39.2 and 28.1 months, respectively. Multivariate analysis demonstrated that only positive final surgical margin was predictive of worse outcome (P = 0.002). Recurrences were most frequent in the first 2 years. Conclusions Despite the relatively more aggressive nature of periocular malignancies that have invaded the orbit, orbital exenteration offers an overall 2-year DFS of 60%. BCC had the greatest mean survival time, however this was not statistically significant. We found worse prognosis with positive final surgical margins and recommend a multidisciplinary surgical approach to achieve complete resection when indicated.

show abstract

Section: Discussionmentioning

confidence: 99%

Orbital exenteration for advanced periorbital non-melanoma skin cancer: prognostic factors and survival

Gerring

Ott

Curry

et al. 2016

Eye

View full text Add to dashboard Cite

show abstract

“…[7][8][9][10] These techniques offer rapid healing and provide for the application of prosthesis. However they are not suitable in cases where tumour recurrence is likely.…”

Section: Discussionmentioning

confidence: 99%

“…(2,9,10) Other studies from tropical regions show a preponderance of SCC as indication for OE 3 . In this study most of our patients had neglected ocular surface SCC.…”

Section: 11mentioning

confidence: 99%

“…1 OE has not been shown to produce a cure in most cases but controls local disease and may prolong life, sometimes, when used with other adjuvant therapy (chemotherapy and radiotherapy). 2 In developing countries, where patients present with advanced fungating tumours, the procedure may improve the quality of life for the rest of their life time.…”

Section: Introductionmentioning

confidence: 99%

“…3,6 Several techniques for cosmetic repair have also been described. [7][8][9][10] However in some cases the orbit is left to granulate. 3 This study reports our experience of OE in a Teaching Hospital in Accra, Ghana.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations