Orbital Wall Fracture Repair Using Seprafilm

Taban, Mehryar; Nakra, Tanuj; Mancini, Ronald; Douglas, Raymond S.; Goldberg, Robert A.

doi:10.1097/iop.0b013e3181a2fd1e

Cited by 20 publications

(7 citation statements)

References 16 publications

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“…The authors reported the application of Seprafilm to be safe in patients undergoing repeated strabismus surgery [80]. In another report, Seprafilm was applied in four subjects (six sites total) with orbital fractures and entrapped orbital soft tissue [81]. Seprafilm was placed over the fracture in these “trap doors”, with no subsequent need for reoperation and with no complications.…”

Section: Human Investigational Uses Of Seprafilmmentioning

confidence: 99%

Seprafilm® adhesion barrier: (1) a review of preclinical, animal, and human investigational studies

et al. 2012

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The aim of this study was to provide a single site resource for investigators, clinicians, and others seeking preclinical, animal, and human investigational studies concerning the postsurgical, anti-adhesion barrier Seprafilm™ (Genzyme Corporation, Cambridge, MA). All published preclinical, animal, human extra-abdominal research as of July 2011 have been summarized and included in this document. Searches of Medline and EMBASE Drugs and Pharmaceuticals databases were conducted for original preclinical, animal, and human extra-abdominal studies involving Seprafilm. Preclinical, animal, and extra-abdominal human investigational studies are the study selection for this manuscript. Intraabdominal use is discussed in the accompanying manuscript. Data extraction includes systematic manuscript review. Summary of preclinical, animal, and extra-abdominal human investigational use of Seprafilm by surgical discipline were gathered for data synthesis. The clinical use of Seprafilm, which was approved by the FDA for intra-abdominal procedures, is supported by preclinical and animal studies relating to general surgical and obstetrical/gynecological applications. Findings from preclinical, animal, and human investigational studies at other sites throughout the body raises the potential for additional human clinical trials to assess efficacy and safety following surgical procedures at non-abdominal locations.

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Section: Human Investigational Uses Of Seprafilmmentioning

confidence: 99%

Seprafilm® adhesion barrier: (1) a review of preclinical, animal, and human investigational studies

et al. 2012

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“…We believe that LactoSorb being a smooth nonporous implant creates a physical barrier between the titanium mesh and the periorbital tissues preventing the formation of adhesions; this mechanism could be similar to the one proposed with other implants like Supramid or Seprafilm. 24,25 This could be proven with a histopathologic study.…”

Section: Discussionmentioning

confidence: 92%

Combined Use of Titanium Mesh and Resorbable PLLA-PGA Implant in the Treatment of Large Orbital Floor Fractures

Magaña

Arzac

Avilés

2011

Journal of Craniofacial Surgery

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“…The use of HACMC solution (Guardix-sol®) during dacryocystorhinostomy was reported to effectively reduce occlusion and adhesion of the rhinostomy site 9. Furthermore, the use of Seprafilm®, a film structure of HACMC, significantly reduced the occurrence of adhesion between the conjunctiva, periosteum, and muscles after surgery and reduced the occurrence of adhesion and ocular movement disorder after orbital fracture repair surgery 7,10. However, Seprafilm® was difficult to manipulate and reposition once it contacted the tissue 7.…”

Section: Discussionmentioning

confidence: 99%

“…6 - 9 In addition, a mixture of sodium hyaluronate (HA) and carboxymethylcellulose (CMC), also known as Seprafilm® (Genzyme Corp., Cambridge, MA, USA), has been used in orbital wall reconstruction. 10 …”

Section: Introductionmentioning

confidence: 99%

Clinical Effect of a Mixed Solution of Sodium Hyaluronate and Sodium Carboxymethylcellulose During the Transconjunctival Approach for Orbital Wall Reconstruction

Kang

Lee

et al. 2012

Chonnam Med J

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This study aimed to evaluate the anti-adhesive effect of a mixed solution of sodium hyaluronate and sodium carboxymethylcellulose (HACMC, Guardix-sol®) during the transconjunctival approach to orbital wall reconstruction. Eighty-seven patients who underwent orbital wall reconstruction by the transconjunctival approach were enrolled in this prospective study. We applied HACMC between the orbicularis oculi muscle and the orbital septum after surgery in 47 patients and did not use it in 40 patients. Lower lid retraction and marginal reflex distance 2 (MRD2) were measured to analyze the degree of postoperative adhesion at 1 week and 1, 3, and 6 months. The degree of MRD2 showed clinically significant differences at postoperative 1 week and 1 month between the HACMC and control groups (p<0.05). Lower lid ectropion developed in two patients (5.0%) in the control group but did not occur in the HACMC group. In orbital wall reconstruction by the transconjunctival approach, the HACMC mixture solution is effective for preventing adhesion and lower lid ectropion during the early postoperative period.

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Orbital Wall Fracture Repair Using Seprafilm

Abstract: Seprafilm may have a role in reconstruction of the "trap door" type of orbital wall fractures. The ease of use, lack of fixation, and absorbable properties without inflammation are encouraging for further study.

Cited by 20 publications

References 16 publications

Seprafilm® adhesion barrier: (1) a review of preclinical, animal, and human investigational studies

Seprafilm® adhesion barrier: (1) a review of preclinical, animal, and human investigational studies

Combined Use of Titanium Mesh and Resorbable PLLA-PGA Implant in the Treatment of Large Orbital Floor Fractures

Clinical Effect of a Mixed Solution of Sodium Hyaluronate and Sodium Carboxymethylcellulose During the Transconjunctival Approach for Orbital Wall Reconstruction

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