Ordered nanoporous silica as carriers for improved delivery of water insoluble drugs: a comparative study between three dimensional and two dimensional macroporous silica

Wang, Ying; Zhao, Qinfu; Hu, Yanchen; Sun, Lizhang; Bai, Ling; Jiang, Tongying; Wang, Siling

doi:10.2147/ijn.s52605

Cited by 92 publications

(38 citation statements)

References 47 publications

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“…The uptake and release of drug molecules generally depend on the specific surface area, total pore volume and pore diameter of the mesoporous silica materials [27,30,41]. Basically, the reason for using such measurements is to investigate any modification of the textural properties of the porous silica material.…”

Section: Textural Propertiesmentioning

confidence: 99%

“…The effective loading of drug molecules and their subsequent controlled release are facilitated by the unique mesoporous structure of the silica nanoparticles in the form of an ordered pore network, with uniform tunable mesopores that allow close control over drug loading and release kinetics; high pore volume able to host the required amount of pharmaceuticals; high specific surface area with good potential for drug adsorption; and a rich silanol groups-containing surface that can be functionalized to improve control over drug loading and release [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

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Development of a Prolonged-Release Drug Delivery System with Magnolol Loaded in Amino-Functionalized Mesoporous Silica

et al. 2017

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Magnolol (MG) is a small-molecule neolignan polyphenolic compound isolated from the genus Magnolia. The anti-inflammatory, anti-oxidative, anti-diabetic, anti-tumorgenic, anti-neurodegenerative, anti-depressant and anti-microbial properties of MG are well documented in recent literature. These fascinating multiple biological activities of MG encourage research about the development of new delivery and administration approaches able to maximize its potential benefits. This study describes the amino-functionalization of the SBA-15 (Santa Barbara Amorphous) mesoporous matrix by post-synthesis grafting using APTES (3-aminopropyltriethoxysilane) and the characterization of amino-functionalized mesoporous silica SBA-15 loaded with MG in order to achieve modified drug delivery systems. The amino-functionalization of silica SBA-15 was carried out by grafting by refluxing in dry toluene. The powders obtained were characterized texturally by Brunauer-Emmett-Teller (BET) surface area analysis measurements and morphologically by scanning electron microscopy. MG loading degree in the nanoporous matrix was determined by the HPLC method at λ = 290 nm. Results showed that by grafting the amino groups in the silica SBA-15, we obtained amino-functionalized silica SBA-15 with an ordered structure, with specific surfaces and pore sizes that differ from the original matrix, which was reflected in the amount of MG immobilized and release kinetics profile.

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Section: Textural Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of a Prolonged-Release Drug Delivery System with Magnolol Loaded in Amino-Functionalized Mesoporous Silica

et al. 2017

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“…Prolonging the physical stability of amorphous ART is one of the important factors that need to be considered to preserve the enhanced physicochemical properties (Wang et al, 2013). Therefore, the physical stability of ART/SBA-15 formulations upon storage was investigated under three different storage conditions up to 6 months.…”

Section: Physical Stability Of Amorphous Artmentioning

confidence: 99%

Enhanced dissolution and stability of artemisinin by nano-confinement in ordered mesoporous SBA-15 particles

Letchmanan

Shen

et al. 2015

Journal of Microencapsulation

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Dissolution of poorly water-soluble drug, Artemisinin (ART), was enhanced by encapsulating the drug particles inside pore channels of ordered mesoporous silica, SBA-15, via co-spray drying. The drug release profiles of ART were investigated by using flow-through cell (USP IV) and in vitro dissolution tester (USP II). The co-spray-dried ART/SBA-15 samples demonstrated significantly improved dissolution rates and supersaturation compared to the untreated ART. The low cytotoxicity effect of ART and SBA-15 on Caco-2 cells after 24 h incubation demonstrated the biocompatibility of ART/SBA-15. Finally, the storage stability of the samples was investigated for 6 months under five different storage conditions. Overall, the solid dispersions exhibited excellent physical stability; however, their chemical stability was affected by humidity regardless of storage temperatures. The formulation of solid dispersions of ART/SBA-15 is potentially safe and an effective approach to enhance the solubility of poorly water-soluble ART.

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“…MSNs were discovered in 1992 by the Mobile Oil Corporation. They have received considerable attention due to their outstanding features, such as a high surface area, large pore volume, tunable pore diameter, narrow pore size distribution [7][8][9][10][11][12][13][14][15], easily modified surface [16], good biocompatibility and thermal stability [17].…”

Section: Introductionmentioning

confidence: 99%

“…This refers to pores acting as passages between the external and internal surfaces of a solid, allowing material to pass into, through, or out of the solid [16]. The possibility of using mesoporous materials such as Santa Barbara Amorphous-15 (SBA-15) or Mobile Crystalline Matter-48 (MCM-48) and some metal organic frameworks as drug carriers and controlled release systems has been discussed [18,19].…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Silica Nanoparticles (MSN): A Nanonetwork and Hierarchical Structure in Drug Delivery

Jadhav¹

2015

JNMR

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Chemistry, synthesis and functionalization of MSNsWith an abundant availability of various types of surfactants and the development of a deep understanding of sol-gel chemistry, MSNs with different structures have been developed. The size, morphology, pore size and pore structure of MSNs can be rationally designed and the synthesis process can be freely AbstractNanotechnology is a fast-growing area, involving the fabrication and use of nano-sized materials and devices. Nanocomposite materials play a number of important roles in modern science and technology, including pharmaceutical science. Mesoporous materials in particular have a large number of applications. In the past decade, mesoporous silica nanoparticles (MSNs) attracted attention increasingly for their potential biomedical applications. With their tailored mesoporous structure and high surface area, MSNs have significant advantages as drug delivery systems (DDSs) compared with traditional drug nanocarriers. Inorganic mesoporous materials are being used increasingly in pharmaceutical materials research to enhance the dissolution and permeation behavior of drugs that are poorly soluble in water. The benefits of using mesoporous materials in drug delivery applications stem from their large surface area and pore volume. These properties enable the materials to accommodate large amounts of payload molecules, protect them from premature degradation and promote controlled and fast release. As carriers with various morphologies and chemical surface properties can be produced, these materials may even promote adsorption from the gastrointestinal tract to the systemic circulation. In this work, we review recent progress in the synthesis and surface functionalization of MSNs for drug delivery applications.

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Ordered nanoporous silica as carriers for improved delivery of water insoluble drugs: a comparative study between three dimensional and two dimensional macroporous silica

Cited by 92 publications

References 47 publications

Development of a Prolonged-Release Drug Delivery System with Magnolol Loaded in Amino-Functionalized Mesoporous Silica

Development of a Prolonged-Release Drug Delivery System with Magnolol Loaded in Amino-Functionalized Mesoporous Silica

Enhanced dissolution and stability of artemisinin by nano-confinement in ordered mesoporous SBA-15 particles

Mesoporous Silica Nanoparticles (MSN): A Nanonetwork and Hierarchical Structure in Drug Delivery

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