Ordered three-dimensional nanomaterials using DNA-prescribed and valence-controlled material voxels

Tian, Ye; Lhermitte, Julien; Bai, Liang; Vo, Thi; Xin, Huolin L.; Li, Huilin; Li, Ruipeng; Fukuto, Masafumi; Yager, Kevin G.; Kahn, Jason S.; Xiong, Yan; Minevich, Brian; Kumar, Sanat K.; Gang, Oleg

doi:10.1038/s41563-019-0550-x

Cited by 224 publications

(244 citation statements)

References 45 publications

Supporting

Mentioning

241

Contrasting

Order By: Relevance

“…This offers promising prospects for the in situ analysis of more complex NP samples, such as those encountered during the intermediate steps in the construction of DNA-programmed supercrystals. [47,48] In its "no flow" variation, DEP-modulated spectroscopy can function with very small (sub-microliter) volumes of NP samples. The samples can be recovered unaltered.…”

Section: Resultsmentioning

confidence: 99%

Dielectrophoretically Modulated Optical Spectroscopy of Colloidal Nanoparticle Solutions in Microfluidic Channels

Midelet

Werts

2020

Part & Part Syst Charact

View full text Add to dashboard Cite

Optical spectroscopic techniques (e.g., extinction, scattering, and fluorescence spectroscopies) are important for the analysis of colloidal solutions of nanoparticles (NPs). They are routinely applied to plasmonic and quantum-dot NP samples assuming that these contain a single population of particles with modest size and shape dispersity. However, these spectroscopic techniques become less effective when the sample is a mixture of particles with different sizes, shapes, or composition. Here, an original microfluidic method is proposed for the optical spectroscopic analysis of colloidal NP solutions that combines periodic trapping of NPs by dielectrophoresis (DEP) with in situ optical extinction spectroscopy. The periodic trapping leads to modulation of the continuously monitored optical spectrum depending on the DEP properties of the NPs. DEP-modulated spectroscopy is demonstrated using colloidal gold NPs as small as 40 nm diameter. It is found that the DEP modulation is significantly enhanced when employing suitable microfluidic flow over a multielectrode array. Finally, it is shown that the method can identify and characterize the NP species simultaneously present in a mixture of 40 and 80 nm gold NPs, opening the way toward optical spectroscopic analysis of higher complexity NP mixtures through the combination of the DEP-modulated spectroscopy with chemometric methods.

show abstract

Section: Resultsmentioning

confidence: 99%

Dielectrophoretically Modulated Optical Spectroscopy of Colloidal Nanoparticle Solutions in Microfluidic Channels

Midelet

Werts

2020

Part & Part Syst Charact

View full text Add to dashboard Cite

show abstract

“…Importantly, the research group of Bathe et al has already shown that their designer wireframe DNA origami shapes may have an imminent biomedical application, as they created various precise multivalent arrangements of a clinically-relevant HIV gp120 immunogen on the virus-like DNA particles to systematically probe their impact on B cell triggering in vitro [94]. We strongly believe that all these versatile structures will find uses not only in biological research but also in assembling novel functional materials [95][96][97][98].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Increasing Complexity in Wireframe DNA Nanostructures

et al. 2020

View full text Add to dashboard Cite

Structural DNA nanotechnology has recently gained significant momentum, as diverse design tools for producing custom DNA shapes have become more and more accessible to numerous laboratories worldwide. Most commonly, researchers are employing a scaffolded DNA origami technique by “sculpting” a desired shape from a given lattice composed of packed adjacent DNA helices. Albeit relatively straightforward to implement, this approach contains its own apparent restrictions. First, the designs are limited to certain lattice types. Second, the long scaffold strand that runs through the entire structure has to be manually routed. Third, the technique does not support trouble-free fabrication of hollow single-layer structures that may have more favorable features and properties compared to objects with closely packed helices, especially in biological research such as drug delivery. In this focused review, we discuss the recent development of wireframe DNA nanostructures—methods relying on meshing and rendering DNA—that may overcome these obstacles. In addition, we describe each available technique and the possible shapes that can be generated. Overall, the remarkable evolution in wireframe DNA structure design methods has not only induced an increase in their complexity and thus expanded the prevalent shape space, but also already reached a state at which the whole design process of a chosen shape can be carried out automatically. We believe that by combining cost-effective biotechnological mass production of DNA strands with top-down processes that decrease human input in the design procedure to minimum, this progress will lead us to a new era of DNA nanotechnology with potential applications coming increasingly into view.

show abstract

“…This idea is generally considered the origin of DNA nanotechnology. Structural DNA nanotechnology focuses on the programmability and specificity of DNA molecules, and aims to assemble DNA structures into crystals or to guide the crystallization of other components [ 2 , 3 , 4 ]. Some results show that this technology can achieve precise control of materials in nano-scale [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Using DNA origami, a large number of nanostructures with prescribed shapes and sizes have been constructed. In addition, monodisperse structures can be further assembled into large periodic lattices [ 2 , 13 , 14 , 15 ]. For example, Tian et al assembled polyhedral origami structures into multiple superlattice frameworks and co-crystallized them with nanoparticles of different compositions [ 2 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, monodisperse structures can be further assembled into large periodic lattices [ 2 , 13 , 14 , 15 ]. For example, Tian et al assembled polyhedral origami structures into multiple superlattice frameworks and co-crystallized them with nanoparticles of different compositions [ 2 , 14 ]. Although these self-assembly methods are slightly different in assembly methods and purposes, the goals of uniform development are to improve assembly controllability and to build more complex structures.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bottom-Up Self-Assembly Based on DNA Nanotechnology

et al. 2020

Self Cite

View full text Add to dashboard Cite

Manipulating materials at the atomic scale is one of the goals of the development of chemistry and materials science, as it provides the possibility to customize material properties; however, it still remains a huge challenge. Using DNA self-assembly, materials can be controlled at the nano scale to achieve atomic- or nano-scaled fabrication. The programmability and addressability of DNA molecules can be applied to realize the self-assembly of materials from the bottom-up, which is called DNA nanotechnology. DNA nanotechnology does not focus on the biological functions of DNA molecules, but combines them into motifs, and then assembles these motifs to form ordered two-dimensional (2D) or three-dimensional (3D) lattices. These lattices can serve as general templates to regulate the assembly of guest materials. In this review, we introduce three typical DNA self-assembly strategies in this field and highlight the significant progress of each. We also review the application of DNA self-assembly and propose perspectives in this field.

show abstract

Ordered three-dimensional nanomaterials using DNA-prescribed and valence-controlled material voxels

Cited by 224 publications

References 45 publications

Dielectrophoretically Modulated Optical Spectroscopy of Colloidal Nanoparticle Solutions in Microfluidic Channels

Dielectrophoretically Modulated Optical Spectroscopy of Colloidal Nanoparticle Solutions in Microfluidic Channels

Increasing Complexity in Wireframe DNA Nanostructures

Bottom-Up Self-Assembly Based on DNA Nanotechnology

Contact Info

Product

Resources

About