Orexin A in the ventral tegmental area induces conditioned place preference in a dose-dependent manner: Involvement of D1/D2 receptors in the nucleus accumbens

Taslimi, Zahra; Arezoomandan, Reza; Omranifard, Alireza; Ghalandari-Shamami, Mohadeseh; Riahi, Esmail; Vafaei, Abbas Ali; Rashidy-Pour, Ali; Haghparast, Abbas

doi:10.1016/j.peptides.2012.07.023

Cited by 40 publications

(13 citation statements)

References 33 publications

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“…In contrast, other studies have reported that blockade of both families of dopamine receptor subtypes in Acb interfered with acquisition of CPP induced by morphine (Fenu et al, 2006), amphetamine (Liao, 2008) or intra-VTA orexin A (Taslimi et al, 2012) in rats and by methampetamine in mice (Kurokawa et al, 2012). Thus, the overall pattern of findings suggests that the role of Acb D2-like dopamine receptors during CPP acquisition varies depending on the conditioning drug and species.…”

Section: Discussionmentioning

confidence: 87%

“…Experiments 1 and 2 examined the effects of intra-Acb injection of the D1-receptor antagonist SCH23390 or the D2-receptor antagonist raclopride, respectively, on the acquisition of ethanol-induced CPP in DBA/2J mice, an inbred strain that is known to be especially sensitive to ethanol reward in this procedure (Cunningham, Niehus, Malott, & Prather, 1992). On the basis of previous studies we predicted that Acb D1-receptor blockade would interfere with CPP acquisition, but we were uncertain about effects of Acb D2-receptor blockade since previous CPP studies have shown both positive (Fenu et al, 2006; Liao, 2008; Kurokawa et al, 2012; Taslimi, Arezoomandan, Omranifard, Ghalandari-Shamami, Riahi, Vafaei, Rashidy-Pour & Haghparast, 2012) and negative (Baker, Khroyan, O'Dell, Fuchs & Neisewander, 1996; Liu et al, 2011; Spina et al, 2006) effects. Experiments 3 and 4 examined the effects of D1- and D2-receptor blockade on the expression of ethanol-induced CPP.…”

Section: Introduction1mentioning

confidence: 99%

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Role of nucleus accumbens dopamine receptor subtypes in the learning and expression of alcohol-seeking behavior

Young

Dreumont

Cunningham

2014

Neurobiology of Learning and Memory

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These studies examined the roles of dopamine D1- and D2-like receptors within the nucleus accumbens (Acb) in the acquisition and expression of ethanol-induced (2 g/kg) conditioned place preference (CPP) in adult male DBA/2J mice. Bilateral intra-Acb infusions of the D1-like dopamine receptor antagonist SCH23390 (0.05, 0.5 µg/side) or the D2-like dopamine receptor antagonist raclopride (0.5–5.0 µg/side) were administered 30 min before each ethanol conditioning trial (acquisition studies) or before preference tests (expression studies). CPP was conditioned to tactile cues using an unbiased apparatus and procedure. Intra-Acb infusion of SCH23390 prevented CPP acquisition, whereas intra-Acb infusion of raclopride did not. Intra-Acb infusion of both antagonists, however, dose-dependently reduced ethanol-stimulated locomotor activity during conditioning. In contrast, intra-Acb antagonist infusion had no effect on ethanol CPP expression, suggesting that dopamine’s role in the Acb is limited to neurobiological processes engaged during the learning of the relationship between contextual cues and ethanol reward. Control experiments showed that intra-Acb injection of SCH23390 alone produced no place conditioning and did not interfere with the acquisition of conditioned place aversion induced by lithium chloride, suggesting that the antagonist’s effect on ethanol CPP was not due to a more general detrimental effect on associative learning. Overall, these data suggest that D1-like (but not D2-like) dopamine Acb receptors play an important role in the learning of context-ethanol associations, either by modulating the magnitude of ethanol reward or the rate of learning about ethanol reward.

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Section: Discussionmentioning

confidence: 87%

Section: Introduction1mentioning

confidence: 99%

Role of nucleus accumbens dopamine receptor subtypes in the learning and expression of alcohol-seeking behavior

Young

Dreumont

Cunningham

2014

Neurobiology of Learning and Memory

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“…The effects of subcutaneous (sc) administrations of morphine on induction of place conditioning in animals were determined in previous studies (Reisi et al, 2014;Taslimi et al, 2012;Zarepour et al, 2013). Each morphine dose (0.5, 1, 2.5, 5, 7.5 and 10 mg/kg; sc) was injected on a 3-day schedule of conditioning as described above.…”

Section: Experimental Designmentioning

confidence: 99%

Microinjection of the mGluR5 antagonist MTEP into the nucleus accumbens attenuates the acquisition but not expression of morphine-induced conditioned place preference in rats

Roohi

Sarihi

Shahidi

et al. 2014

Pharmacology Biochemistry and Behavior

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“…In tests of conditioned place preference (CPP) following pairing with drug administration, VTA injection of OX-A during conditioning induces morphine CPP in a dose-dependent manner [121], and peripheral administration of the OX1R antagonist SB-334867 or OX2R antagonist TCS-OX2-29 suppresses its acquisition and expression [122, 123]. While morphine CPP may be perpetuated by OX binding at OX1R or OX2R, ethanol CPP appears to be mediated more by OX2R.…”

Section: Role In Rewardmentioning

confidence: 99%

Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior

Barson

Morganstern

Leibowitz

2013

International Journal of Endocrinology

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Transcribed within the lateral hypothalamus, the neuropeptides orexin/hypocretin (OX) and melanin-concentrating hormone (MCH) both promote palatable food intake and are stimulated by palatable food. While these two neuropeptides share this similar positive relationship with food, recent evidence suggests that this occurs through different albeit complementary effects on behavior, with OX promoting food seeking and motivation for palatable food and MCH functioning during ongoing food intake, reinforcing the consumption of calorically dense foods. Further differences are evident in their effects on physiological processes, which are largely opposite in nature. For example, activation of OX receptors, which is neuronally excitatory, promotes waking, increases energy expenditure, and enhances limbic dopamine levels and reward. In contrast, activation of MCH receptors, which is neuronally inhibitory, promotes paradoxical sleep, enhances energy conservation, reduces limbic dopamine, and increases depressive behavior. This review describes these different effects of the neuropeptides, developing the hypothesis that they stimulate the consumption of palatable food through excessive seeking in the case of OX and through excessive energy conservation in the case of MCH. It proposes that OX initiates food intake and subsequently stimulates MCH which then acts to prolong the consumption of palatable, energy-dense food.

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Orexin A in the ventral tegmental area induces conditioned place preference in a dose-dependent manner: Involvement of D1/D2 receptors in the nucleus accumbens

Cited by 40 publications

References 33 publications

Role of nucleus accumbens dopamine receptor subtypes in the learning and expression of alcohol-seeking behavior

Role of nucleus accumbens dopamine receptor subtypes in the learning and expression of alcohol-seeking behavior

Microinjection of the mGluR5 antagonist MTEP into the nucleus accumbens attenuates the acquisition but not expression of morphine-induced conditioned place preference in rats

Complementary Roles of Orexin and Melanin-Concentrating Hormone in Feeding Behavior

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