Orexin A modulates neuronal activity of the rodent suprachiasmatic nucleus <i>in vitro</i>

Klisch, Christopher; Inyushkin, A. N.; Mordel, Jérôme; Karnas, Diana; Pévet, Paul; Meissl, Hilmar

doi:10.1111/j.1460-9568.2009.06794.x

Cited by 43 publications

(32 citation statements)

References 41 publications

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“…In addition, both orexinergic fibres and receptors are present in the SCN (McGranaghan and Piggins 2001). The firing rate of SCN cells in vitro is altered when orexin A and B are applied (Brown et al 2008;Klisch et al 2009). For animals entrained to daily hedonic meals, orexinergic neurons are much more activated than those of animals without the daily snack and exhibit an increased activity of dopamine-and serotonin-containing neurons (Mendoza et al 2010a).…”

Section: Effects Of Food-related Motivational Cues On the Suprachiasmmentioning

confidence: 98%

Metabolic and reward feeding synchronises the rhythmic brain

Challet

Mendoza

2010

Cell Tissue Res

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Daily brain rhythmicity, which controls the sleep-wake cycle and neuroendocrine functions, is generated by an endogenous circadian timing system. Within the multi-oscillatory circadian network, a master clock is located in the suprachiasmatic nuclei of the hypothalamus, whose main synchroniser (Zeitgeber) is light. In contrast, imposed meal times and temporally restricted feeding are potent synchronisers for secondary clocks in peripheral organs such as the liver and in brain regions, although not for the suprachiasmatic nuclei. Even when animals are exposed to a light-dark cycle, timed calorie restriction (i.e. when only a hypocaloric diet is given every day) is a synchroniser powerful enough to modify the suprachiasmatic clockwork and increase the synchronising effects of light. A daily chocolate snack in animals fed ad libitum with chow diet entrains the suprachiasmatic clockwork only under the conditions of constant darkness and decreases the synchronising effects of light. Secondary clocks in the brain outside the suprachiasmatic nuclei are differentially influenced by meal timing. Circadian oscillations can either be highly sensitive to food-related metabolic or reward cues (i.e. their phase is shifted according to the timed meal schedule) in some structures or hardly affected by meal timing (palatable or not) in others. Furthermore, animals will manifest food-anticipatory activity prior to their expected meal time. Anticipation of a palatable or regular meal may rely on a network of brain clocks, involving metabolic and reward systems and the cerebellum.

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Section: Effects Of Food-related Motivational Cues On the Suprachiasmmentioning

confidence: 98%

Metabolic and reward feeding synchronises the rhythmic brain

Challet

Mendoza

2010

Cell Tissue Res

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“…In the case of the suprachiasmatic nucleus, this innervation can explain the tight relationship between the orexinergic system and the control of circadian rhythmicity [Klisch et al, 2009;Blasiak et al, 2017]. In the basal hypothalamus of holostean fishes, along with the OX-ir cells, abundant fibers course in the tuberal region and reach the median eminence, as has also been observed in cladistians, lungfishes, amphibians, reptiles, and mammals Date et al, 2000;López et al, 2009aLópez et al, , 2009bLópez et al, , 2014Domínguez et al, 2010].…”

Section: Distribution Of Oxir Fibers In the Brain Of Vertebratesmentioning

confidence: 87%

Organization of the Orexin/Hypocretin System in the Brain of Holostean Fishes: Assessment of Possible Relationships with Monoamines and Neuropeptide Y

Lozano

González

López³

2018

Brain Behav Evol

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Holosteans form a small group of actinopterygian fishes considered the sister group of teleosts. Despite this proximity to the biggest group of vertebrates, relatively few studies have been conducted to investigate the organization of the central nervous system of this group of fishes. In this study, the neuroanatomical distribution of orexin/hypocretin-like immunoreactive (OX-ir) cell bodies and fibers was analyzed in the brain of 3 representative species of the 2 orders of extant holosteans, the spotted gar Lepisosteus oculatus, the Florida gar Lepisosteus platyrhincus, and the bowfin Amia calva. Antibodies against orexin-A (OXA) and orexin-B (OXB) were used, which labeled the same cells and fibers throughout the brain. In addition, double immunohistofluorescence was performed for the simultaneous detection of OXA and OXB with tyrosine hydroxylase, serotonin, and neuropeptide Y (NPY), in an attempt to localize the orexinergic structures precisely and study the possible interactions between these neuroactive substances. The pattern of distribution of OX-ir cells in the 3 species was largely similar, showing labeled cells in the preoptic area (POA), and the tuberal and retrotuberal hypothalamic regions, with only subtle differences between species in the density of labeled cells. OX-ir fibers were found in all main brain subdivisions of the 3 species, mostly in the ventral subpallial areas, POA, hypothalamus, posterior tubercle, thalamus, and mesencephalic tectum. Different densities of orexinergic fibers were observed in relation to catecholaminergic and serotoninergic cell groups, as well as an absence of colocalization between orexins and NPY in the same hypothalamic neurons. The comparison of these results with those obtained in other vertebrates highlights a constant pattern of distribution of this system of neurotransmission among different groups of actinopterygian fishes, especially in teleosts. Conserved features shared by all vertebrates studied were also observed, such as the presence of OX-ir cells in the basal hypothalamus, reflecting the preserved functions of these neuropeptides over the course of evolution.

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“…Orexins have been found to modulate not only neuronal activity in the suprachiasmatic nucleu (10) but also that of the trigeminal nucleus via afferents from the posterior hypothalamus (11). The orexins could serve as mediators between these two systems and explain the connection between pain and rhythmicity.…”

Section: Discussionmentioning

confidence: 98%

Ten years of chronic cluster – attacks still cluster

Jürgens

Koch²,

May

2010

Cephalalgia

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The chronic variant can be found in 10-20% of all cluster headache patients. While circadian and circannual rhythmicity are characteristic of the episodic variant, little is known on chronobiology in chronic cluster headache. We report a patient with chronic cluster evolved from episodic who recorded a total of 5447 attacks over 10 years. After spectral analysis, cosinor models were calculated within the frequency ranges of 23-25 h (circadian) and 11-13 months (circannual), respectively. Significant results (P < 0.01) were found for 24-h periods, but not for circannual intervals (12 months). However, with regard to circannual periodicity, a semi-circannual rhythm (5-7 months) was suitable for curve fit and yielded significant results in the cosinor analysis at 6 months (P < 0.05). This remarkable long observation period of 10 years shows that, at least for secondary chronic cluster headache which evolved from the episodic form, a typical circadian and circannual rhythmicity comparable to that of episodic cluster headache exists.

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Orexin A modulates neuronal activity of the rodent suprachiasmatic nucleus in vitro

Cited by 43 publications

References 41 publications

Metabolic and reward feeding synchronises the rhythmic brain

Metabolic and reward feeding synchronises the rhythmic brain

Organization of the Orexin/Hypocretin System in the Brain of Holostean Fishes: Assessment of Possible Relationships with Monoamines and Neuropeptide Y

Ten years of chronic cluster – attacks still cluster

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