Organ Conservation in Invasive Bladder Cancer by Transurethral Resection, Chemotherapy and Radiation: Results of a Urodynamic and Quality of Life Study on Long-term Survivors

Abstract

The majority of patients treated with trimodality therapy retain good bladder function. A fifth have evidence of bowel dysfunction.

Respuesta y supervivencia libre de progresión en tumores vesicales en estadios T2-T4 tratados con tratamiento trimodal de conservación vesical

“…La supervivencia del grupo (61%; IC 95%: 47-75%) fue similar a lo publicado, así como el porcentaje que conservó la vejiga in situ, que en nuestro caso fue del 53% y que oscila entre el 40-45% en la literatura mé dica 6 .…”

“…Aunque no hay estudios prospectivos ni aleatorizados que comparen la cistectomía y las pautas de conservació n vesical, la supervivencia específica y global es similar a la obtenida con cirugía. El 75% de las vejigas conservadas son normales funcionalmente y la conservació n mejora la calidad de vida global y específicamente cuando hablamos de continencia e impotencia 6 .…”

Quality of Life after Bladder Cancer: A Prospective Study Comparing Patient-related Outcomes after Radical Surgery or Radical Radiotherapy for Bladder Cancer

“…Both the physician assessed symptom scores and the patients' scores from the Nottingham health profile showed those with a complete response to radiotherapy had little change in their QoL. Zietman et al published comparable findings for 71 patients who were alive and disease-free a median of 6.3 years (range 1.6-14.9) following transurethral resection, chemotherapy and radiotherapy for MIBC [13]. They used a QoL questionnaire validated for prostate cancer, adapted for the study, and included domains for sexual and physical function, global health functional status, and measures of body awareness.…”

“…Studies evaluating QoL outcomes following radical radiotherapy for bladder cancer are largely limited to small, single centre, retrospective series and some using physician reported or unvalidated questionnaires [10][11][12][13]. At the time of assessments most participants are recurrence-free biasing the information collected.…”

“…Notably, the degree to which sexual function is influenced in women is less well documented. Perhaps due to some extent because bladder cancer incidence is less in women, though in one QoL study women preferred not to answer the question [13].…”