Organ Function Biomarker Abnormalities, Associated Factors and Disease Outcome Among Hospitalized Patients with Covid-19

Araya, Shambel; Tsegay, Yakob Gebregziabher; Atlaw, Assegdew; Aragaw, Mintsnot; Tadlo, Getachew; Tsegaye, Nebiyu; Kahase, Daniel; Gebreyohanes, Zenebe; Bitew, Molalegne; Berhane, Nega

doi:10.2217/bmm-2021-0681

Cited by 7 publications

(3 citation statements)

References 56 publications

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“…Thirty-three studies ( 1 , 5 , 6 , 16 , 17 , 19 – 21 , 23 , 26 – 38 , 40 , 41 , 47 , 49 – 56 ) (25,384 subjects) reported outcome data on AST. The pooled WMD of AST levels was higher in severe cases, with high heterogeneity (WMD = 13.98 U/L, 95% CI: 12.13–15.83, I 2 = 98.2%, P Heterogenity = 0.000) ( Figure 3B , Supplementary Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

Liver injury associated with the severity of COVID-19: A meta-analysis

Yang

Feng

Wan

et al. 2023

Front. Public Health

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BackgroundThe current 2019 novel coronavirus disease (COVID-19) pandemic is a major threat to global health. It is currently uncertain whether and how liver injury affects the severity of COVID-19. Therefore, we conducted a meta-analysis to determine the association between liver injury and the severity of COVID-19.MethodsA systematic search of the PubMed, Embase, and Cochrane Library databases from inception to August 12, 2022, was performed to analyse the reported liver chemistry data for patients diagnosed with COVID-19. The pooled odds ratio (OR), weighted mean difference (WMD) and 95% confidence interval (95% CI) were assessed using a random-effects model. Furthermore, publication bias and sensitivity were analyzed.ResultsForty-six studies with 28,663 patients were included. The pooled WMDs of alanine aminotransferase (WMD = 12.87 U/L, 95% CI: 10.52–15.23, I2 = 99.2%), aspartate aminotransferase (WMD = 13.98 U/L, 95% CI: 12.13–15.83, I2 = 98.2%), gamma-glutamyl transpeptidase (WMD = 20.67 U/L, 95% CI: 14.24–27.10, I2 = 98.8%), total bilirubin (WMD = 2.98 μmol/L, 95% CI: 1.98–3.99, I2 = 99.4%), and prothrombin time (WMD = 0.84 s, 95% CI: 0.46–1.23, I2 = 99.4%) were significantly higher and that of albumin was lower (WMD = −4.52 g/L, 95% CI: −6.28 to −2.75, I2 = 99.9%) in severe cases. Moreover, the pooled OR of mortality was higher in patients with liver injury (OR = 2.72, 95% CI: 1.18–6.27, I2 = 71.6%).ConclusionsHepatocellular injury, liver metabolic, and synthetic function abnormality were observed in severe COVID-19. From a clinical perspective, liver injury has potential as a prognostic biomarker for screening severely affected patients at early disease stages.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, Identifier: CRD42022325206.

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Section: Resultsmentioning

confidence: 99%

Liver injury associated with the severity of COVID-19: A meta-analysis

Yang

Feng

Wan

et al. 2023

Front. Public Health

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“…This is clearly shown by the increased rate of abnormal urea and creatinine values on admission in those patients who subsequently died (between 75% and 80%) compared to those who were discharged (between 20% and 24%). [34][35][36][37] Detection of urea was performed by using an enzymatic reaction and the chromogenic reaction of phenol red, as illustrated in Scheme S1 (ESI †). This reaction involves hydrolysis of urea by urease, producing ammonia, which results in an increase in pH.…”

Section: Colorimetric Response Towards Spike Sar-cov-2 Antigenmentioning

confidence: 99%

Alternative platform for COVID-19 diagnosis based on AuNP-modified lab-on-paper

Punnoy

Siripongpreda

Pisitkun

et al. 2023

Analyst

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“…Common laboratory tests included procalcitonin (PCT) [9], C-reactive protein (CRP) [10], D-dimer [11], interleukin-6 (IL-6) [12], and others [13]. In addition, parameters reflecting organ dysfunction have been extensively studied [14][15][16][17]. To assist diagnosis and prognosis, simple models have been constructed based on some of these parameters and demographic information such as age, sex, and number of comorbidities [18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

A two-gene marker for the two-tiered innate immune response in COVID-19 patients

Lei

2023

PLoS ONE

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For coronavirus disease 2019 (COVID-19), a pandemic disease characterized by strong immune dysregulation in severe patients, convenient and efficient monitoring of the host immune response is critical. Human hosts respond to viral and bacterial infections in different ways, the former is characterized by the activation of interferon stimulated genes (ISGs) such as IFI27, while the latter is characterized by the activation of anti-bacterial associated genes (ABGs) such as S100A12. This two-tiered innate immune response has not been examined in COVID-19. In this study, the activation patterns of this two-tiered innate immune response represented by IFI27 and S100A12 were explored based on 1421 samples from 17 transcriptome datasets derived from the blood of COVID-19 patients and relevant controls. It was found that IFI27 activation occurred in most of the symptomatic patients and displayed no correlation with disease severity, while S100A12 activation was more restricted to patients under severe and critical conditions with a stepwise activation pattern. In addition, most of the S100A12 activation was accompanied by IFI27 activation. Furthermore, the activation of IFI27 was most pronounced within the first week of symptom onset, but generally waned after 2–3 weeks. On the other hand, the activation of S100A12 displayed no apparent correlation with disease duration and could last for several months in certain patients. These features of the two-tiered innate immune response can further our understanding on the disease mechanism of COVID-19 and may have implications to the clinical triage. Development of a convenient two-gene protocol for the routine serial monitoring of this two-tiered immune response will be a valuable addition to the existing laboratory tests.

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Organ Function Biomarker Abnormalities, Associated Factors and Disease Outcome Among Hospitalized Patients with Covid-19

Cited by 7 publications

References 56 publications

Liver injury associated with the severity of COVID-19: A meta-analysis

Liver injury associated with the severity of COVID-19: A meta-analysis

Alternative platform for COVID-19 diagnosis based on AuNP-modified lab-on-paper

A two-gene marker for the two-tiered innate immune response in COVID-19 patients

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