Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways

Kim, Woo Seok; Hong, Sungcheol; Gamero, Milenka; Jeevakumar, Vivekanand; Price, Theodore J.; Campos, Carlos; Palmiter, Richard D.; Park, Sung Il

doi:10.21203/rs.3.rs-38538/v1

Cited by 8 publications

(11 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The actuating mechanism enabled by a reed switch can extend battery life to up to seven years. Radiofrequency (RF) energy harvesting could be another embodiment of the proposed approach [ 39 , 42 , 43 , 44 ]. A wireless coil embedded in an implanted device induces inductive coupling between an implanted device and a portable device to power the wireless Bluetooth or NFC chip.…”

Section: Discussionmentioning

confidence: 99%

Multimodal Sensing Capabilities for the Detection of Shunt Failure

Gamero

Kim

Hong

et al. 2021

Sensors

Self Cite

View full text Add to dashboard Cite

Hydrocephalus is a medical condition characterized by the abnormal accumulation of cerebrospinal fluid (CSF) within the cavities of the brain called ventricles. It frequently follows pediatric and adult congenital malformations, stroke, meningitis, aneurysmal rupture, brain tumors, and traumatic brain injury. CSF diversion devices, or shunts, have become the primary therapy for hydrocephalus treatment for nearly 60 years. However, routine treatment complications associated with a shunt device are infection, obstruction, and over drainage. Although some (regrettably, the minority) patients with shunts can go for years without complications, even those lucky few may potentially experience one shunt malfunction; a shunt complication can require emergency intervention. Here, we present a soft, wireless device that monitors distal terminal fluid flow and transmits measurements to a smartphone via a low-power Bluetooth communication when requested. The proposed multimodal sensing device enabled by flow sensors, for measurements of flow rate and electrodes for measurements of resistance in a fluidic chamber, allows precision measurement of CSF flow rate over a long time and under any circumstances caused by unexpected or abnormal events. A universal design compatible with any modern commercial spinal fluid shunt system would enable the widespread use of this technology.

show abstract

Section: Discussionmentioning

confidence: 99%

Multimodal Sensing Capabilities for the Detection of Shunt Failure

Gamero

Kim

Hong

et al. 2021

Sensors

Self Cite

View full text Add to dashboard Cite

show abstract

“…Simultaneous activation of multiple animals in 4 home cages using a single RF power source is achieved primarily due to a channel isolation strategy and the use of a supercapacitor. Recently, we introduced a novel channel isolation strategy for high-throughput operation 38 . Although it permits independent activation of cages up to 8, it is unable to simultaneously activate cages.…”

Section: Discussionmentioning

confidence: 99%

Al-enabled, implantable, multichannel wireless telemetry for photodynamic therapy

Kim

Khot

Woo

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is an alternative method for treating cancers, and its outcomes are highly dependent on light delivery to tumor cells to activate a photosensitizer. Existing approaches paired with advances in wireless technologies enable remote delivery of light to tumors but suffer from poor spatiotemporal resolution due to inabilities to minimize oxygen depletion in a tumor. Here, we introduce AI-informed low-power wireless telemetry with an integrated thermal/light simulation platform that bypasses all constraints above. The simulator leads to the optimized combination of wavelengths and light sources, and AI-assisted wireless telemetry uses the parameters from the simulator to enable adequate illumination of tumors through high-throughput (< 20 mice) and multi-wavelength operation. They establish a range of guidelines for effective PDT regimen design. Hypericin and Foscan mediated PDT demonstrated substantial suppression of tumor growth, suggesting that the proposed platform provides the potential for widespread use in fundamental research and/or clinical settings.

show abstract

“…The code for 3D reconstruction image is available from Github (https://github.com/ parkgroup-tamu/3d_reconstruction) and also from Zenodo 40 .…”

Section: Data Availabilitymentioning

confidence: 99%

Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways

et al. 2021

Self Cite

View full text Add to dashboard Cite

The vagus nerve supports diverse autonomic functions and behaviors important for health and survival. To understand how specific components of the vagus contribute to behaviors and long-term physiological effects, it is critical to modulate their activity with anatomical specificity in awake, freely behaving conditions using reliable methods. Here, we introduce an organ-specific scalable, multimodal, wireless optoelectronic device for precise and chronic optogenetic manipulations in vivo. When combined with an advanced, coil-antenna system and a multiplexing strategy for powering 8 individual homecages using a single RF transmitter, the proposed wireless telemetry enables low cost, high-throughput, and precise functional mapping of peripheral neural circuits, including long-term behavioral and physiological measurements. Deployment of these technologies reveals an unexpected role for stomach, non-stretch vagal sensory fibers in suppressing appetite and demonstrates the durability of the miniature wireless device inside harsh gastric conditions.

show abstract

Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways

Cited by 8 publications

References 35 publications

Multimodal Sensing Capabilities for the Detection of Shunt Failure

Multimodal Sensing Capabilities for the Detection of Shunt Failure

Al-enabled, implantable, multichannel wireless telemetry for photodynamic therapy

Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways

Contact Info

Product

Resources

About