Organic carbamates in drug development. Part II: antimicrobial agents -
                        Recent reports

Ray, Suprabhat; Pathak, Seema R.; Chaturvedi, Devdutt

doi:10.1358/dof.2005.030.02.869228

Cited by 58 publications

(24 citation statements)

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“…[65] For example, methyl diphenyl diisocyanate (MDI), a key material in polyurethane synthesis, is produced by this route. Amine phosgenation involves carbamate intermediates, industrially interesting molecules per se (having end applications as foams, adhesives, [66] agrochemicals, [67] drugs, and prodrugs [68] ) and precursors to ureas [69] and to isocyanate, with a market of several million tons per year. [57] Because carbamates are potentially amenable to CO 2 chemistry, their industrial development as well as related isocyanate production could become a frontier of the industrial utilization of CO 2 (Scheme 3).…”

Section: Isocyanatesmentioning

confidence: 99%

Carbon Dioxide Recycling: Emerging Large‐Scale Technologies with Industrial Potential

et al. 2011

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This Review introduces this special issue of ChemSusChem dedicated to CO(2) recycling. Its aim is to offer an up-to-date overview of CO(2) chemical utilization (inorganic mineralization, organic carboxylation, reduction reactions, and biochemical conversion), as a continuation and extension of earlier books and reviews on this topic, but with a specific focus on large-volume routes and projects/pilot plants that are currently emerging at (pre-)industrial level. The Review also highlights how some of these routes will offer a valuable opportunity to introduce renewable energy into the existing energy and chemical infrastructure (i.e., "drop-in" renewable energy) by synthesis of chemicals from CO(2) that are easy to transport and store. CO(2) conversion therefore has the potential to become a key pillar of the sustainable and resource-efficient production of chemicals and energy from renewables.

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Section: Isocyanatesmentioning

confidence: 99%

Carbon Dioxide Recycling: Emerging Large‐Scale Technologies with Industrial Potential

et al. 2011

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“…They can be used as anticancer, antimicrobial and antimalarial agents, and in many other areas. 1,2 The chemistry of urethanes as anticancer agents has mainly been used to develop the socalled prodrugs. It was also shown that the presence of one urethane residue in the compounds demonstrating biological activity improves their pharmacological and pharmacokinetic properties.…”

Section: Introductionmentioning

confidence: 99%

Reinvestigation of the structure of monensin A phenylurethane sodium salt based on X-ray crystallographic and spectroscopic studies, and its activity against hospital strains of methicillin-resistant S. epidermidis and S. aureus

et al. 2011

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Monensin A phenylurethane sodium salt (MON-UR1-Na) crystals were studied by the X-ray, NMR, FT-IR and PM5 semi-empirical methods. The X-ray data show that the compound forms a pseudocyclic structure, stabilized by three intramolecular hydrogen bonds, and the sodium cation coordinated by five oxygen atoms in the hydrophilic sphere. The NMR and FT-IR data demonstrate that this pseudocyclic structure is also conserved in CH(2)Cl(2) solution. This structure of MON-UR1-Na is significantly different than the ones previously proposed by Westley et al. and Tanaka et al. The semi-empirical calculations of the MON-UR1-Na structures indicate that the one of the crystal is the most energetically favorable one. Other parameters, such as the size, chemical and biological nature of the urethane substituent, and especially the free carbonyl urethane group, may have a role in the biological activity of MON-UR1-Na. The in vitro microbiological tests provide evidence that MON-UR1-Na shows higher antibacterial activity against human pathogenic bacteria, including antibiotic-resistant Staphylococcus aureus and Staphylococcus epidermidis than the parent unmodified antibiotic-Monensin A.

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“…The principal aim of the present study is to assess the quality of reactivity predictions coming from alternative theoretical approaches for the alkaline hydrolysis of substituted phenyl N ‐phenylcarbamates. Carbamates are well‐known class of compounds that can be synthesized by various methods 1–4. The interest for studying their properties is determined mostly by the biological activities of carbamate derivatives 1–11.…”

Section: Introductionmentioning

confidence: 99%

“…Carbamates are well‐known class of compounds that can be synthesized by various methods 1–4. The interest for studying their properties is determined mostly by the biological activities of carbamate derivatives 1–11. Various carbamates find application in the agrochemical industry5–9 as herbicides, fungicides and pesticides, in the pharmaceuticals industry5, 6, 10 as drug intermediates, and in the polymer industry5, 6, 11 for the synthesis of polyurethane and peptides.…”

Section: Introductionmentioning

confidence: 99%

Thermally Stable Porous Hydrogen‐Bonded Coordination Networks Displaying Dual Properties of Robustness and Dynamics upon Guest Uptake

Jiang

Lan

et al. 2010

Chemistry A European J

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Two series of microporous lanthanide coordination networks of the general formula, {[Ln(ntb)Cl(3)] x xH(2)O}(n) (series 1: monoclinic C2/c, Ln = Sm and Tb; series 2: hexagonal P3(1)/c, Ln = Sm and Eu; ntb = tris(benzimidazol-2-ylmethyl)amine, x = 0-4) have been synthesized and characterized by IR, elemental analyses, thermal gravimetry, and single-crystal and powder X-ray diffraction methods. In both series, the monomeric [Ln(ntb)Cl(3)] coordination units are consolidated by N-H...Cl or C-H...Cl hydrogen bonds to sustain three-dimensional (3D) networks. However, the different modes of hydrogen bonding in the two series lead to crystallization of the same [Ln(ntb)Cl(3)] monomers in different forms (monoclinic vs. hexagonal), consequently giving rise to distinct porous structures. The resulting hydrogen-bonded coordination networks display high thermal stability and robustness in water removal/inclusion processes, which was confirmed by temperature-dependent single-crystal-to-single-crystal transformation measurements. Adsorption studies with H(2), CO(2), and MeOH have been carried out, and reveal distinct differences in adsorption behavior between the two forms. In the case of MeOH uptake, the monoclinic network shows a normal type I isotherm, whereas the hexagonal network displays dynamic porous properties.

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Organic carbamates in drug development. Part II: antimicrobial agents - Recent reports

Cited by 58 publications

References 0 publications

Carbon Dioxide Recycling: Emerging Large‐Scale Technologies with Industrial Potential

Carbon Dioxide Recycling: Emerging Large‐Scale Technologies with Industrial Potential

Reinvestigation of the structure of monensin A phenylurethane sodium salt based on X-ray crystallographic and spectroscopic studies, and its activity against hospital strains of methicillin-resistant S. epidermidis and S. aureus

Thermally Stable Porous Hydrogen‐Bonded Coordination Networks Displaying Dual Properties of Robustness and Dynamics upon Guest Uptake

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