Organic conjugated small molecules with donor–acceptor structures: design and application in the phototherapy of tumors

Abstract

Tumor phototherapies mainly including photothermal therapy (PTT) and photodynamic therapy (PDT) have drawn more and more attention due to their various merits of minimal drug resistance, low invasiveness and good...

Multifunctional nanomicelles constructedviaan aggregation and de-aggregation strategy for magnetic resonance/NIR II fluorescence imaging-guided type I photodynamic therapy

“…To obtain low-bandgap AIE PSs, the D–A strategy is generally employed. 36 In this work, we chose thiadiazolo[3,4- g ]quinoxaline (TQ) and triphenylamine (TPA) as the electron-accepting and donating moieties to build the target molecule, TQ-TPA, and its synthetic route is shown in Fig. 2A.…”

Imaging of mitochondria/lysosomes in live cells and C. elegans

“…2,4 Several photosensitizers such as porphyrins, quinones, chalcogen-containing dyes, squaraines, cyanines, and fullerenes have been explored for clinical and in vivo applications. [5][6][7][8][9][10] Despite their availability, there is still a need for newer systems with improved therapeutic efficacy and the ability to provide real-time imaging to understand the underlying mechanistic pathways better.…”

Integrating Pillar[5]arene and BODIPY for a Supramolecular Nanoplatform To Achieve Synergistic Photodynamic Therapy and Chemotherapy

“…[2] In face of these problems, single treatment method is often difficult to solve the perfect. [3][4][5][6][7][8] Chemotherapy (CT) efficacy are limited by drug resistance and the limited drug accumulation in the tumors. [9][10] Photodynamic therapy (PDT), which is completed by a photosensitizer that absorbs light energy to produce reactive oxygen species (ROS) to kill tumor cells, is limited by the O 2 content of tumor cells.…”

“…Too many factors such as deep infiltration, complicated location and hypoxia microenvironment make it difficult for tumor cells to be completely removed [2] . In face of these problems, single treatment method is often difficult to solve the perfect [3–8] . Chemotherapy (CT) efficacy are limited by drug resistance and the limited drug accumulation in the tumors [9–10] .…”