Organic Electrochemistry: Molecular Syntheses with Potential

Zhu, Cancan; Ang, Nate W. J.; Meyer, Tjark H.; Qiu, Youai; Ackermann, Lutz

doi:10.1021/acscentsci.0c01532

Cited by 517 publications

(186 citation statements)

References 319 publications

Supporting

Mentioning

182

Contrasting

Unclassified

Order By: Relevance

“…Given the sustainable nature of photo-induced C−H activation with reusable transition metal catalysts, we strongly believe that further exciting advances can be envisaged in this research arena, which will guide recyclable and environmentally sound methodologies for molecular assembly-line synthesis. These should require multidisciplinary collaborations, including the exploration of alternative metals [60], the engineering of innovative materials [61,62], electrocatalysis [63][64][65][66], and asymmetric C−H transformations [67,68], among others.…”

Section: Discussionmentioning

confidence: 99%

C–H activation by immobilized heterogeneous photocatalysts

Choi

Struwe

Ackermann

2021

Photochem Photobiol Sci

Self Cite

View full text Add to dashboard Cite

During the last decades, the merger of photocatalysis with transition metal chemistry has been surfaced as a sustainable tool in modern molecular syntheses. This Account highlights major advances in synergistic photo-enabled C‒H activations. Inspired by our homogenous ruthenium- and copper-catalyzed C‒H activations in the absence of an exogenous photosensitizer, this Account describes the recent progress on heterogeneous photo-induced C‒H activation enabled by immobilized hybrid catalysts until September 2021, with a topical focus on recyclability as well as robustness of the heterogeneous photocatalyst.

show abstract

Section: Discussionmentioning

confidence: 99%

C–H activation by immobilized heterogeneous photocatalysts

Choi

Struwe

Ackermann

2021

Photochem Photobiol Sci

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although the cross-dehydrogenative coupling (CDC), [70][71][72] cross-coupling hydrogen evolution reaction(CCHER), [73][74][75][76] and electrochemical oxidative cross-coupling [77][78][79][80][81] reactions are growing strategies for © AUTHOR(S) direct C-H alkynylation, application of diazonium salts for Sonogashira coupling provides a good alternative for the easy and user-friendly synthesis of diarylacetylenes.…”

Section: Discussionmentioning

confidence: 99%

Sonogashira coupling of arenediazonium salts: discovery and developments

Panda¹

2021

Arkivoc

View full text Add to dashboard Cite

Colourful chemistry: Arenediazonium salts represent efficient, common, easily available aryl surrogates from inexpensive anilines and show higher reactivity compare to aryl halides and triflates towards various crosscoupling reactions. We have disclosed the Sonogashira coupling of arenediazonium salts in 2010; afterward, several groups successfully developed various protocols for this reaction. This mini-review describes the discovery and progress of the alkynylation of arenediazonium salts in due time, highlights the strengths and weaknesses of each protocol.

show abstract

“…Indeed, some practical electrochemical oxidations of unactivated C−H bonds have been developed and applied to derivation of complex molecules. ( Ackermann et al, 2021 )…”

Section: C-h Oxidations For Natural Product Diversificationmentioning

confidence: 99%

Novel Strategies in C-H Oxidations for Natural Product Diversification—A Remote Functionalization Application Summary

et al. 2021

View full text Add to dashboard Cite

Selectively activating the distal inactive C-H bond for functionalization is one of the on-going challenge in organic synthetic chemistry. In recent years, benefiting from the development of selective synthesis methods, novel methodologies not only make it possible to break non-traditional chemical bonds and attain more diversity in inactive sites, but also provide more possibilities for the diversification of complex natural products. Direct C-H bond functionalization approaches make it feasible to explore structure-activity relationship (SAR), generate metabolites and derivatives, and prepare biological probes. Among them, direct oxidation of inert C-H bonds is one of the most common methods for natural product diversification. In this review, we focus on the application of remote functionalization of inert C-H bonds for natural products derivatization, including the establishment of oxidation methods, the regulation of reaction sites, and the biological activities of derivatives. We highlight the challenges and opportunities of remote functionalization of inert C-H bonds for natural product diversification through selected and representative examples. We try to show that inert C-H bond oxidation, properly regulated and optimized, can be a powerful and efficient strategy in both synthetic and medicinal chemistry.

show abstract

Organic Electrochemistry: Molecular Syntheses with Potential

Cited by 517 publications

References 319 publications

C–H activation by immobilized heterogeneous photocatalysts

C–H activation by immobilized heterogeneous photocatalysts

Sonogashira coupling of arenediazonium salts: discovery and developments

Novel Strategies in C-H Oxidations for Natural Product Diversification—A Remote Functionalization Application Summary

Contact Info

Product

Resources

About