Organic small molecule-based photothermal agents for cancer therapy: Design strategies from single-molecule optimization to synergistic enhancement

Ding, Zhonglong; Gu, Yinhui; Zheng, Cheng; Gu, Yueqing; Yang, Jing; Li, Dahong; Yang, Xu; Wang, Peng

doi:10.1016/j.ccr.2022.214564

Cited by 83 publications

(47 citation statements)

References 90 publications

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“…Such techniques present advantages including active targeting of cancer cells, toxicity reduction, and integration of multiple functions. 13,14 Therefore, smart advanced materials not only provide an extraordinarily powerful platform to achieve direct monitoring of biological species and activities but also enable the implementation of photo-based therapeutic methods. Recently, several types of organic/inorganic materials have been developed, which include, but are not limited to, rare earth-doped nanomaterials, 15 organic fluorophores, 16 singlewalled carbon nanotubes, 17 and quantum dots.…”

Section: Zhongzhong Lumentioning

confidence: 99%

Effective design of organic luminogens for near-infrared-II fluorescence imaging and photo-mediated therapy

Kamya

Cao

et al. 2022

J. Mater. Chem. B

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Section: Zhongzhong Lumentioning

confidence: 99%

Effective design of organic luminogens for near-infrared-II fluorescence imaging and photo-mediated therapy

Kamya

Cao

et al. 2022

J. Mater. Chem. B

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“…organic and inorganic nanomaterials. So far, small molecule dyes [ 23 – 25 ] and conjugated polymers [ 26 – 28 ] as the representatives of organic PTAs have been extensively explored for PTT. On the other hand, noble metal nanoparticles (NPs) [ 29 , 30 ], metal chalcogenide NPs [ 31 , 32 ] and 2D nanomaterials [ 33 , 34 ] are popular inorganic PTAs.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment

et al. 2022

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Near-infrared-II (NIR-II, 1000–1700 nm) light-triggered photothermal therapy (PTT) has been regarded as a promising candidate for cancer treatment, but PTT alone often fails to achieve satisfactory curative outcomes. Hollow nanoplatforms prove to be attractive in the biomedical field owing to the merits including good biocompatibility, intrinsic physical-chemical nature and unique hollow structures, etc. On one hand, hollow nanoplatforms themselves can be NIR-II photothermal agents (PTAs), the cavities of which are able to carry diverse therapeutic units to realize multi-modal therapies. On the other hand, NIR-II PTAs are capable of decorating on the surface to combine with the functions of components encapsulated inside the hollow nanoplatforms for synergistic cancer treatment. Notably, PTAs generally can serve as good photoacoustic imaging (PAI) contrast agents (CAs), which means such kind of hollow nanoplatforms are also expected to be multifunctional all-in-one nanotheranostics. In this review, the recent advances of NIR-II hollow nanoplatforms for single-modal PTT, dual-modal PTT/photodynamic therapy (PDT), PTT/chemotherapy, PTT/catalytic therapy and PTT/gas therapy as well as multi-modal PTT/chemodynamic therapy (CDT)/chemotherapy, PTT/chemo/gene therapy and PTT/PDT/CDT/starvation therapy (ST)/immunotherapy are summarized for the first time. Before these, the typical synthetic strategies for hollow structures are presented, and lastly, potential challenges and perspectives related to these novel paradigms for future research and clinical translation are discussed. Graphical Abstract

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“…Among them, organic compounds possess unique intrinsic merits including excellent reproducibility, specific chemical structures, and good biocompatibility [ 22 , 23 , 24 , 25 , 26 ]. Currently, small-molecule dyes, i.e., indocyanine green (ICG) and methylene blue (MB) have been approved by the Food and Drug Administration (FDA) for clinical use, highlighting the great clinical translation potential of organic optical materials [ 27 , 28 , 29 ]. Nevertheless, most conventional organic dyes are planar structures, which face the obstacle of aggregation-caused quenching (ACQ) effect in aggregate state due to strong intermolecular interactions (e.g., π-π stacking) [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Reactive Species-Activatable AIEgens for Biomedical Applications

Kang

Yin

et al. 2022

Biosensors

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Precision medicine requires highly sensitive and specific diagnostic strategies with high spatiotemporal resolution. Accurate detection and monitoring of endogenously generated biomarkers at the very early disease stage is of extensive importance for precise diagnosis and treatment. Aggregation-induced emission luminogens (AIEgens) have emerged as a new type of excellent optical agents, which show great promise for numerous biomedical applications. In this review, we highlight the recent advances of AIE-based probes for detecting reactive species (including reactive oxygen species (ROS), reactive nitrogen species (RNS), reactive sulfur species (RSS), and reactive carbonyl species (RCS)) and related biomedical applications. The molecular design strategies for increasing the sensitivity, tuning the response wavelength, and realizing afterglow imaging are summarized, and theranostic applications in reactive species-related major diseases such as cancer, inflammation, and vascular diseases are reviewed. The challenges and outlooks for the reactive species-activatable AIE systems for disease diagnostics and therapeutics are also discussed. This review aims to offer guidance for designing AIE-based specifically activatable optical agents for biomedical applications, as well as providing a comprehensive understanding about the structure–property application relationships. We hope it will inspire more interesting researches about reactive species-activatable probes and advance clinical translations.

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Organic small molecule-based photothermal agents for cancer therapy: Design strategies from single-molecule optimization to synergistic enhancement

Cited by 83 publications

References 90 publications

Effective design of organic luminogens for near-infrared-II fluorescence imaging and photo-mediated therapy

Effective design of organic luminogens for near-infrared-II fluorescence imaging and photo-mediated therapy

Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment

Reactive Species-Activatable AIEgens for Biomedical Applications

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