Organization, nucleotide sequence, and transcription of the chicken HSP70 gene.

Morimoto, Richard I.; Hunt, Clayton R.; Huang, Shu Ying; Berg, Karl-Heinz Linne von; Banerji, Sunandita S.

doi:10.1016/s0021-9258(18)67147-9

Cited by 103 publications

(1 citation statement)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This way, the overexpression of hsf1 in samples taken during the danger category can be explained because this gene is the main modulator of heat shock response [39]. hsf1 plays an essential role in cells subjected to heat shock or other proteotoxic conditions by protecting against stressors by positively regulating HSP mRNA levels [40][41][42]. For example, HSF1 interaction between HSP70 and its companion HSP40 has been correlated with increased hsp70 gene expression [43,44].…”

Section: Discussionmentioning

confidence: 99%

Expression profiling of heat shock protein genes in whole blood of Romosinuano cattle breed

et al. 2023

View full text Add to dashboard Cite

Background and Aim: Heat shock proteins are highly conserved proteins that work as molecular chaperones expressed in response to thermal stress. This study aimed to determine the expression profile of genes related to the heat stress response in whole blood obtained from the Romosinuano creole breed. Materials and Methods: Real-time polymerase chain reaction was performed to analyze the transcript of hsp90, hsp70, hsp60, and hsf1 in the whole blood of Romosinuano under different temperature-humidity indices (THIs). Results: The expression levels of the hsp70 and hsf1 genes at the high-THI level were higher (p = 0.0011 and p = 0.0003, respectively) than those at the low-THI level. In addition, no differences in the expression levels of the hsp60 and hsP90 genes were detected between the two THIs. Conclusion: The overexpression of hsf1 and hsp70 genes play an important role in protecting cells from damage induced by heat stress. Keywords: climate change, external environment, heat shock proteins, heat stress, mRNA, temperature-humidity index.

show abstract

Section: Discussionmentioning

confidence: 99%

Expression profiling of heat shock protein genes in whole blood of Romosinuano cattle breed

et al. 2023

View full text Add to dashboard Cite

show abstract

Activation signals regulate heat shock transcription factor 1 in human B lymphocytes

et al. 1997

View full text Add to dashboard Cite

We previously showed that the ability of human B lymphocytes to elicit a cytoprotective heat shock response when confronted by heat or other stresses was dependent upon the state of cell activation. This was unexpected, considering the highly conserved nature of the heat shock response and the widely held belief that all nonmutated mature cells were capable of eliciting a heat shock response when stressed. To elucidate the mechanism by which activation primes B cells to respond to stresses, we examined heat shock transcription factor 1 (hHSF1) in B cells since this factor appears to be solely responsible for stress-induced transcription of heat shock genes in human cells. In the current report, we show that hHSF1-DNA binding complexes are undetectable in extracts of unactivated B cells. In fact, hHSF1 protein is not constitutively expressed in unactivated B cells, nor is its synthesis stress-inducible. However, following activation, hHSF1 can be found in either a transcriptionally active or an inactive state, depending upon whether the cell has been stressed or not. Thus, activation pathways play an important role in enabling B cells to survive and function properly in the context of physiologic stresses by regulating hHSF1.

show abstract

Expression of cell death regulatory genes and limited apoptosis induction in avian blastodermal cells

1998

View full text Add to dashboard Cite

Organization, nucleotide sequence, and transcription of the chicken HSP70 gene.

Cited by 103 publications

References 52 publications

Expression profiling of heat shock protein genes in whole blood of Romosinuano cattle breed

Expression profiling of heat shock protein genes in whole blood of Romosinuano cattle breed

Activation signals regulate heat shock transcription factor 1 in human B lymphocytes

Expression of cell death regulatory genes and limited apoptosis induction in avian blastodermal cells

Contact Info

Product

Resources

About