Smart healthcare technologies have transformed the healthcare landscape, promising precision, efficiency, and improved patient outcomes. However, these advancements bring significant ethical, privacy, and security challenges. The increased use of AI and data-driven systems in healthcare raises questions about patient autonomy, data ownership, and informed consent. As large volumes of sensitive health data are generated, ensuring robust security measures is critical to protecting patient privacy. Moreover, the push for cost-effectiveness in healthcare often conflicts with ethical obligations, necessitating a balanced approach. Health economics also impacts ethical decision-making, as stakeholders must navigate the trade-offs between cost containment and quality care. This chapter explores these complexities, examining frameworks to address ethical, privacy, and security concerns. Through case studies and regulatory perspectives, it offers insights into how smart healthcare can responsibly advance while safeguarding patient rights and public trust.