Organizing Axes in Time and Space; 25 Years of Colinear Tinkering

Kmita, Marie; Duboule, Denis

doi:10.1126/science.1085753

Cited by 484 publications

(272 citation statements)

References 34 publications

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“…In contrast, genes in the human β-globin cluster are lined in the order of temporal timing of expression (Jane and Cunningham, 1996;Li et al, 2006). Several models to explain the regulatory mechanism of this concerted expression have been proposed (Kmita and Duboule, 2003;Li et al, 2006;Negre and Ruiz, 2007). With the CPR genes, there was no coordinated regulation of genes in tandem arrays except for the subsets of some RR-2 genes that are found in sequence clusters.…”

Section: Coordination Of Regulationmentioning

confidence: 95%

Developmental expression patterns of cuticular protein genes with the R&R Consensus from Anopheles gambiae

Togawa

Dunn

Emmons

et al. 2008

Insect Biochemistry and Molecular Biology

106

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CPR proteins are the largest cuticular protein family in arthropods. The whole genome sequence of Anopheles gambiae revealed 156 genes that code for proteins with the R&R Consensus and named CPRs. This protein family can be divided into RR-1 and RR-2 subgroups, postulated to contribute to different regions of the cuticle. We determined the temporal expression patterns of these genes throughout post-embryonic development by means of real-time qRT-PCR. Based on expression profiles, these genes were grouped into 21 clusters. Most of the genes were expressed with sharp peaks at single or multiple periods associated with molting. Genes coding for RR-1 and RR-2 proteins were found together in several co-expression clusters. Twenty-five genes were expressed exclusively at one metamorphic stage. Five out of six X-linked genes showed equal expression in males and females, supporting the presence of a gene dosage compensation system in An. gambiae. Many RR-2 genes are organized into sequence clusters whose members are extremely similar to each other and generally closely associated on a chromosome. Most genes in each sequence cluster are expressed with the same temporal expression pattern and at the same level, suggesting a shared mechanism to regulate their expression.

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Section: Coordination Of Regulationmentioning

confidence: 95%

Developmental expression patterns of cuticular protein genes with the R&R Consensus from Anopheles gambiae

Togawa

Dunn

Emmons

et al. 2008

Insect Biochemistry and Molecular Biology

106

View full text Add to dashboard Cite

show abstract

“…Then a progressive 3 0 -5 0 change in high-order chromatin structure, which is manifested as the movement outside of chromatin territories, is necessary to allow for the programmed expression of genes along the cluster. In parallel with Hox colinearity, a sequential opening of chromatin, starting at the 3 0 end of a cluster and moving successively toward 5 0 , leads to the release of silencing first at the 3 0 end, and sequentially, allowing the expression of more 5 0 genes (Roelen et al, 2002;Kmita and Duboule, 2003;Duboule and Deschamps, 2004). In hematopoietic cells, menin-MLL complexes modulate the chromatin accessibility to upstream regulators of Hox genes (Figure 1a).…”

Section: Initiation Of Hox Expressionmentioning

confidence: 99%

Epigenetic regulations in hematopoietic Hox code

Hua

Yan

2010

Oncogene

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“…Although most analyses have been performed in the forelimb (suggesting that the data we present below have been established for the forelimb), they undoubtedly apply to the hindlimb as well. An extensive discussion of this work is beyond the scope of this review, and the reader is referred to recent reviews (Kmita and Duboule, 2003;Freitas and Cohn, 2006). However, major rules are emerging that are presented below.…”

Section: Role Of Tbx Genes In Specification Of More Posterior Identitymentioning

confidence: 99%

Anteroposterior patterning in the limb and digit specification: Contribution of mouse genetics

Robert

Lallemand

2006

Developmental Dynamics

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The limb has been a privileged object of investigation and reflection for scientists over the past two centuries and continues to provide a heuristic framework to analyze vertebrate development. Recently, accumulation of new data has significantly changed our view on the mechanisms of limb patterning, in particular along the anterior-posterior axis. These data have led us to revisit the mode of action of the zone of polarizing activity. They shed light on the molecular and cellular mechanisms of patterning linked to the Shh-Gli3 signaling pathway and give insights into the mechanism of activation of these cardinal factors, as well as the consequences of their activity. These new data are in good part the result of systematic Application of tools used in contemporary mouse molecular genetics. These have extended the power of mouse genetics by introducing mutational strategies that allow fine-tuned modulation of gene expression, interchromosomal deletions and duplication. They have even made the mouse embryo amenable to cell lineage analysis that used to be the realm of chick embryos. In this review, we focus on the data acquired over the last five years from the analysis of mouse limb development and discuss new perspectives opened by these results. Developmental Dynamics 235:2337-2352, 2006.

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Organizing Axes in Time and Space; 25 Years of Colinear Tinkering

Cited by 484 publications

References 34 publications

Developmental expression patterns of cuticular protein genes with the R&R Consensus from Anopheles gambiae

Developmental expression patterns of cuticular protein genes with the R&R Consensus from Anopheles gambiae

Epigenetic regulations in hematopoietic Hox code

Anteroposterior patterning in the limb and digit specification: Contribution of mouse genetics

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