Organizing pneumonia as an initial presentation in a male lupus: A rare case report

Acharya, Suman; Aryal, Roshan; Yadav, Rupesh Kumar; Shrestha, Suraj; Karki, Rajeshri G.; Jha, Saket

doi:10.1002/ccr3.7389

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…A virus infection, stress, or other variables that may excite your immune system and create an autoimmune reaction can combine with a genetic predisposition to cause lupus. 3,4 In general, SLE in men has the same disease spectrum as in women, but with some variation. SLE manifests itself clinically in a very varied way.…”

Section: Discussionmentioning

confidence: 99%

“…According to certain studies, SLE could be the reason for up to 50% of adult patients who come with a fever of unknown origin. 4,5,10 Peripheral neuropathy and vasculitis are more common in men.…”

Section: Discussionmentioning

confidence: 99%

“…Research suggests that a sizable portion of these pre-clinical lupus patients, including those with undifferentiated connective tissue disease or incomplete lupus, may eventually develop clinical lupus and meet the requirements for systemic lupus later in life. [4][5][6] Patients with SLE commonly develop pulmonary involvement; incidence ranges from 24% to 74%. However, only 2-4% of patients present with pulmonary implications as their initial SLE symptom.…”

Section: Introductionmentioning

confidence: 99%

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Systemic lupus erythematous in men with interstitial lung pneumonia: a rare case report

Anjani,

Saputra,

Widyaningsih

2024

Int J Adv Med

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Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with unknown etiology and very diverse clinical manifestations, disease course, and prognosis. It is most common in African-American women, the prevalence being 4 per 1000 females. SLE predominantly affects young women, most presenting between 20 and 40 years of age. Male SLE is rare, with only one male patient reported per nine females. Pulmonary involvement in SLE is various. SLE-associated interstitial lung disease (ILD), while rare, is a predictor of poor prognosis. We report a 50-year-old male patient with complaints of shortness of breath, previously diagnosed with systemic lupus erythematous by examination of the antinuclear antibody (ANA) profile. The patient underwent a computed tomography (CT) scan of the thorax and the results showed interstitial lung pneumonia. The patient was given azathioprine and methylprednisolone therapy for Systemic lupus erythematous and ceftriaxone and acetylcysteine for interstitial lung pneumonia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Systemic lupus erythematous in men with interstitial lung pneumonia: a rare case report

Anjani,

Saputra,

Widyaningsih

2024

Int J Adv Med

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Organizing pneumonia and COVID-19

Tonon,

Tanni,

Rocha

et al. 2023

The American Journal of the Medical Sciences

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Cryptogenic Organizing Pneumonia Is Associated With Increased Mortality Risk in Hospitalizations for Systemic Lupus Erythematosus (SLE): A National Inpatient Sample Analysis

Uwumiro,

Emmanuel,

Offiah

et al. 2024

Cureus

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Background This study analyzed the incidence, characteristics, and mortality risk associated with cryptogenic organizing pneumonia (COP) among hospitalizations for systemic lupus erythematosus (SLE) with lung involvement. Methods Adult hospitalizations from the 2016-2020 nationwide inpatient sample were analyzed using relevant International Classification of Diseases (ICD)-10 codes for SLE with lung involvement (M32.13) and COP (J84.116). We compared baseline characteristics of individuals with SLE and COP to those of other lung involvements using Chi-square tests for categorical variables and the Wilcoxon rank sum test for continuous variables. A Cox proportional hazards model was used to assess the risk of developing COP in the pooled cohort of SLE patients. The impact of COP on SLE mortality was assessed using multivariate logistic regression adjusting for illness severity, baseline risk of mortality at admission, and patient- and hospital-level covariates. Results Of 40,356 admissions for SLE, 3,175 (7.9%) were due to lung involvement, with COP identified in 570 cases (17.9%). Compared with other lung involvement in SLE, individuals with COP were significantly older (mean age: 65 vs. 44.3 years; p<0.001), mostly female (515; 90.4% vs. 2,305 males; 88.5%; p=0.572), had a greater baseline risk of mortality [diagnosis-related groups (DRG) major or extreme likelihood of dying: 360; 63.1% vs. 1,133; 43.5%; p<0.001], and had a higher prevalence of peripheral vascular disease (25; 4.4% vs. 39; 1.5%; p<0.001), and lower prevalence of lymphocytopenia (45; 7.9% vs. 359; 13.8%; p=0.001), and hypothyroidism (44; 7.8% vs. 357; 13.7%; p=0.001). Predictors of COP included female sex [adjusted hazard ratio (AHR): 1.46; 95% confidence interval (CI): 1.12-2.96; p=0.022]; hospitalizations occurring in the third quarter of the year (AHR: 1.37; 95% CI: 1.05-2.23; p=0.038); hospital stays of six days or longer (AHR: 1.71; 95% CI: 1.06-2.77; p=0.029); undergoing five or more procedures during the same hospitalization (AHR: 1.56; 95% CI: 1.26-3.56; p=0.041); coexisting lymphocytopenia (AHR: 1.92; 95% CI: 1.16-3.19; p=0.011); need for mechanical ventilation (AHR: 1.60; 95% CI: 1.48-3.93; p=0.049), presence of another autoimmune disorder (AHR: 1.37; 95% CI: 1.15-4.29; p=0.040), and being hospitalized at private, investor-owned hospitals (AHR: 2.62; 95% CI: 1.03-6.64; p=0.043). Mortality in SLE with lung involvement was correlated with age ≥ 60 years [hazard ratio (HR) (95% CI) 1.16 (1.05-1.56); p=0.012], coexisting lupus nephritis [HR (95% CI), 2.44 (2.04-3.49); p=0.031], cancer [HR (95% CI), 3.49 (2.19-5.79); p<0.001], liver disease [HR (95% CI), 9.82 (4.79-12.57); p<0.001]; immune deficiency [HR (95% CI), 2.22 (2.02-3.11); p=0.031], hypothyroidism [HR (95% CI), 4.67 (1.47-7.75); p=0.009], and high blood pressure [HR (95% CI), 3.15 (2.83-4.51); p<0.001]. In the multivariable analysis, COP remained significantly associated with an increased risk of mortality [AHR (95% CI), 1...

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Organizing pneumonia as an initial presentation in a male lupus: A rare case report

Cited by 3 publications

References 18 publications

Systemic lupus erythematous in men with interstitial lung pneumonia: a rare case report

Systemic lupus erythematous in men with interstitial lung pneumonia: a rare case report

Organizing pneumonia and COVID-19

Cryptogenic Organizing Pneumonia Is Associated With Increased Mortality Risk in Hospitalizations for Systemic Lupus Erythematosus (SLE): A National Inpatient Sample Analysis

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