Orientation Behavior of Chromosome Multiples of Interchange (Reciprocal Translocation) Heterozygotes

Rickards, Geoffrey K.

doi:10.1146/annurev.ge.17.120183.002303

Cited by 85 publications

(81 citation statements)

References 60 publications

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“…Many works on plants and animals have been devoted to the study of factors that affect and modify the meiotic behaviour of structural rearrangements (Sybenga, 1975;Rickards, 1977;1983;Wise & Rickards, 1977;John, 1987;Sybenga & Rickards, 1987;Bidau & Mirol, 1988). Their potential ability to produce negative heterosis through imbalanced segregation is their principal quality relative to speciation (King, 1987).…”

Section: Introductionmentioning

confidence: 99%

“…In the case of translocation (Robertsonjan or reciprocal) heterozygotes such behaviour is ruled by factors such as inter-centromere distance, size of the involved chromosomes, the initial position of the configuration in the meiotic cell, the premeiotic disposition of chromosomes, the relative time of centromere activation, the number and position of chiasmata and the genetic background (Rickards, 1983;Narasinga Rao & Sybenga, 1984;Arundhati et al, 1986;John, 1987;Sybenga & Rickards, 1987). These factors, jointly with selective and stochastic processes, are responsible for the fate of a given chromosomal rearrangement in a natural population.…”

Section: Introductionmentioning

confidence: 99%

“…Symmetry is determined by the interaction of three factors: size of the chromosomes, inter-centromeric distance and frequency and localization of chiasmata; the latter being the most relevant (Rickards, 1983).…”

Section: Introductionmentioning

confidence: 99%

“…Most papers, however, suggest the existence of such a correlation and the relationship between chromosome change and chiasma change is well documented (Sybenga, 1975;Arana et al, 1982;Rickards, 1983;John, 1987;Parker, 1987;Bidau, 1990). On this basis, it is worth analysing how the position of chiasmata can exert influence on the orientation of multiples.…”

Section: Introductionmentioning

confidence: 99%

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Proximal chiasmata induce non-disjunctional orientation of Robertsonian trivalents in a grasshopper

Mirol

Bidau

1992

Heredity

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The relationship between the symmetry of the meiotic configuration and the type of meiotic orientation (disjunctional and non-disjunctional) in Robertsonian trivalents of Dichroplus pratensis (Melanoplinae, Acrididae) was analysed. The results indicate, first, that neither chromosomal size nor the relation between the length of the chromosomes involved in each fusion are important factors for the determination of the orientation. Second, chiasmata localization, which in turn determines effective inter-centromeric distance, may be central. A high positive correlation between proximal chiasma frequency and non-disjunctional orientation at Prometaphase I and Metaphase I was found. These results are in agreement with the hypothesis that the shorter the inter-centromeric distance the greater is the probability that both centromeres migrate to the same pole. The importance of these results is also discussed in relation to the stability of the polymorphisms in this species.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Proximal chiasmata induce non-disjunctional orientation of Robertsonian trivalents in a grasshopper

Mirol

Bidau

1992

Heredity

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“…If this was the case, the variation in fertility of backcrossed progenies could result from multiple translocations and/or altered segregation ratios of alternate and adjacent chromosomes (Burnham, 1962;Rickards, 1983).…”

Section: Relationships Among Recognized Varietiesmentioning

confidence: 99%

A genetic analysis of reproductive barriers in Phacelia dubia

Levy

1991

Heredity

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Investigations into the genetic basis of reproductive barriers among recognized and putative varieties in Phacelia dubia have provided evidence that even among closely related taxa, multiple pathways can lead to reproductive isolation. A nuclear-based reproductive barrier, expressed as partial hybrid sterility of both pollen and ovules, isolated each pair of recognized varieties. There was no evidence of pre-or post-fertilization barriers; all reproductive barriers were manifested as hybrid gametic sterility. Reproductive relationships of two putative varieties were studied to examine the early stages of reproductive isolation in this group. Both putative varieties exhibited partial reproductive isolation from the recognized varieties in spite of their lack of morphological differentiation from recognized varieties. The barrier isolating one putative variety was similar to the barrier among recognized varieties. The second putative variety and a recognized variety were partially isolated by a unidirectional, nuclear-cytoplasmic barrier that reduced only pollen fertility. The nuclear-cytoplasmic barrier suggested a new application of Haldane's rule.

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Meiotic segregation analysis of reciprocal translocations both in sperms and blastomeres

Yakut

Ercelen

Acar

et al. 2006

American J of Med Genetics Pt A

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Balanced chromosomal rearrangements could lead to unbalanced segregation gametes during meiosis. In this study, sperm flourescence in situ hybridization (FISH) analysis of meiotic segregation products of four reciprocal translocations; 46,XY,t(7;10)(q21;q22), 46,XY,t(15;17)(q11;p12), 46,XY,t(6;13)(p21.1;q32), and 46,XY,t(1;13)(q24;q10) are presented. In three out of these four cases with t(15;17), t(6;13), and t(1;13) additional blastomere FISH analyses are also provided. Multi-color FISH analysis was applied using diverse probe combinations specific for translocated chromosome segments. The average frequency of sperm nuclei bearing unbalanced products for t(7;10), t(15;17), t(6;13), and t(1;13) were 48.7%, 59.5%, 60.5%, and 62.9%, respectively. Frequencies of blastomeres comprising unbalanced products in cases with t(15;17), t(6;13), and t(1;13) were 80% (12 of 15), 60% (3 of 5), and 50% (2 of 4), respectively. Chi-square test analysis showed significant differences in the meiotic segregation patterns due to the distribution and numbers of the chiasmatas that could depend on the size of the translocated segments (P < 0.001). In conclusion, FISH analysis of sperm and blastomere for reciprocal translocation carriers effectively estimates the approximate risk of unbalanced products and this result might ensure valuable genetic counseling.

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Orientation Behavior of Chromosome Multiples of Interchange (Reciprocal Translocation) Heterozygotes

Cited by 85 publications

References 60 publications

Proximal chiasmata induce non-disjunctional orientation of Robertsonian trivalents in a grasshopper

Proximal chiasmata induce non-disjunctional orientation of Robertsonian trivalents in a grasshopper

A genetic analysis of reproductive barriers in Phacelia dubia

Meiotic segregation analysis of reciprocal translocations both in sperms and blastomeres

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