ORIGINAL ARTICLE: Brain and hypophyseal acetylcholinesterase activity of pubertal boars fed dietary fumonisin B1

Gbore, Francis Ayodeji

doi:10.1111/j.1439-0396.2010.00992.x

Cited by 7 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(). This study demonstrated that feed contaminated with FB 1 ≥ 5 mg/kg feed for a 6‐month period decreased in a dose dependent manner the release AChE and SAChE activity from some brain regions (Gbore, ).…”

Section: Assessmentmentioning

confidence: 77%

Risks for animal health related to the presence of fumonisins, their modified forms and hidden forms in feed

Knutsen¹,

Alexander²,

Barregård³

et al. 2018

EFS2

View full text Add to dashboard Cite

Fumonisins, mycotoxins primarily produced by Fusarium verticillioides and Fusarium proliferatum, occur predominantly in cereal grains, especially in maize. The European Commission asked EFSA for a scientific opinion on the risk to animal health related to fumonisins and their modified and hidden forms in feed. Fumonisin B 1 (FB 1 ), FB 2 and FB 3 are the most common forms of fumonisins in feedstuffs and thus were included in the assessment. FB 1 , FB 2 and FB 3 have the same mode of action and were considered as having similar toxicological profile and potencies. For fumonisins, the EFSA Panel on Contaminants in the Food Chain (CONTAM) identified no-observed-adverse-effect levels (NOAELs) for cattle, pig, poultry (chicken, ducks and turkeys), horse, and lowest-observed-adverseeffect levels (LOAELs) for fish (extrapolated from carp) and rabbits. No reference points could be identified for sheep, goats, dogs, cats and mink. The dietary exposure was estimated on 18,140 feed samples on FB 1-3 representing most of the feed commodities with potential presence of fumonisins. Samples were collected between 2003 and 2016 from 19 different European countries, but most of them from four Member States. To take into account the possible occurrence of hidden forms, an additional factor of 1.6, derived from the literature, was applied to the occurrence data. Modified forms of fumonisins, for which no data were identified concerning both the occurrence and the toxicity, were not included in the assessment. Based on mean exposure estimates, the risk of adverse health effects of feeds containing FB 1-3 was considered very low for ruminants, low for poultry, horse, rabbits, fish and of potential concern for pigs. The same conclusions apply to the sum of FB 1-3 and their hidden forms, except for pigs for which the risk of adverse health effect was considered of concern.Acknowledgements: The CONTAM Panel wishes to acknowledge all European countries and other stakeholder organisations that provided feed consumption data and chemical occurrence data on fumonisins, modified forms and hidden forms in feed.This is an open access article under the terms of the Creative Commons Attribution-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.The EFSA Journal is a publication of the European Food Safety Authority, an agency of the European Union. Fumonisins in feed www.efsa.europa.eu/efsajournal 2 EFSA Journal 2018;16(5):5242 Fumonisins in feed www.efsa.europa.eu/efsajournal 3 EFSA Journal 2018;16(5):5242Ruminants are considered less sensitive than horses and pigs. Gross and histopathological lesions, as well as changes in serum enzymes and biochemistry indicate an impairment of liver and possibly kidney function. Taking as endpoints the increase in serum enzymes, cholesterol and bilirubin as well as the decrease in lymphocyte blastogenesis a no-observed-adverse-effect level (NOAEL) of (31 mg FB 1-3 /kg feed) could be set only for cattle....

show abstract

Section: Assessmentmentioning

confidence: 77%

Risks for animal health related to the presence of fumonisins, their modified forms and hidden forms in feed

Knutsen¹,

Alexander²,

Barregård³

et al. 2018

EFS2

View full text Add to dashboard Cite

show abstract

“…Kenk et al (305) demonstrated via positron emission tomography imaging of cAMP, a strong region-specific signal in the brain, as well as an impaired cAMP-mediated signalling in obese pigs, giving some insight into pathological progression with potential for directing therapy in humans. Gbore (309) demonstrated that the acetylcholinesterase activity in the hypophyses, hypothalamus and amygdala decreased with increased mycotoxin concentrations in the diet. The decreased feed intake and increased aggressive behaviour observed in subjects contaminated with mycotoxins might be related to anomalies in brain monoamines, including dopamine and serotonin.…”

Section: Differences Between Pigs and Humans Or Pig Studies With No mentioning

confidence: 99%

“…The decreased feed intake and increased aggressive behaviour observed in subjects contaminated with mycotoxins might be related to anomalies in brain monoamines, including dopamine and serotonin. Gbore ( 309 ) demonstrated that the acetylcholinesterase activity in the hypophyses, hypothalamus and amygdala decreased with increased mycotoxin concentrations in the diet. These results are important to identify the risk associated with mycotoxin contamination and possible therapeutic interventions in humans.…”

Section: The Relationship Between Nutrition and The Brain In The Pigmentioning

confidence: 99%

Critical review evaluating the pig as a model for human nutritional physiology

et al. 2016

View full text Add to dashboard Cite

The present review examines the pig as a model for physiological studies in human subjects related to nutrient sensing, appetite regulation, gut barrier function, intestinal microbiota and nutritional neuroscience. The nutrient-sensing mechanisms regarding acids (sour), carbohydrates (sweet), glutamic acid (umami) and fatty acids are conserved between humans and pigs. In contrast, pigs show limited perception of high-intensity sweeteners and NaCl and sense a wider array of amino acids than humans. Differences on bitter taste may reflect the adaptation to ecosystems. In relation to appetite regulation, plasma concentrations of cholecystokinin and glucagon-like peptide-1 are similar in pigs and humans, while peptide YY in pigs is ten to twenty times higher and ghrelin two to five times lower than in humans. Pigs are an excellent model for human studies for vagal nerve function related to the hormonal regulation of food intake. Similarly, the study of gut barrier functions reveals conserved defence mechanisms between the two species particularly in functional permeability. However, human data are scant for some of the defence systems and nutritional programming. The pig model has been valuable for studying the changes in human microbiota following nutritional interventions. In particular, the use of human flora-associated pigs is a useful model for infants, but the long-term stability of the implanted human microbiota in pigs remains to be investigated. The similarity of the pig and human brain anatomy and development is paradigmatic. Brain explorations and therapies described in pig, when compared with available human data, highlight their value in nutritional neuroscience, particularly regarding functional neuroimaging techniques.

show abstract

“…In the other hand, the liver and kidney were also damaged even; they are speci c hosts for FB1 accumulation (Hou et al, 2021;Demirel et al, 2015;Rumora et al, 2007). In the brain, FB1 was able to generate oxidative stress markers (Baldissera et al, 2020), neurochemistry toxicity (Gbore, 2010), facilitated seizures, as well as brain hyperexcitability (Poersh et al, 2015). Several studies reported also that FB1 induced immunotoxicity (Abbès et al, 2016), apoptosis (Zhang et al, 2018;Kim et al, 2018) and genotoxicity (Müller et al, 2012;Pinhão et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The ameliorative effect of Lactobacillus paracasei BEJ01 against FB1 induced spermatogenesis disturbance, testicular oxidative stress and histopathological damage

Ezdini

Salah-Abbès

Belgacem

et al. 2022

Toxicology Mechanisms and Methods

View full text Add to dashboard Cite

Fumonisin B1 (FB1) was a possible carcinogenic molecule for humans as classi ed by the IARC on 2B group. In livestock, it was responsible for several mycotoxicosis and economic losses. Lactobacillus strains, inhabitants of a wide range of foodstuffs as well as our gastro-intestinal tract, were Generally Recognized as Safe (GRAS). Thus, the aim of this work was to evaluate the protective effect of Lactobacillus paracasei (LP) against FB1 induced reprotoxicities including testicular histopathology, sperm quality disturbance and testosterone level reduction.Pubescent mice were divided randomly into four groups as bellow: Group1: Control; Group 2: FB1 (100 µg/kg b.w); Group 3: LP (2× 10 9 CFU/kg b.w); Group 4: LP (2× 10 9 CFU/kg b.w) and FB1 (100 µg/kg b.w) to be then treated for 10 days.After the end of the treatment, animals were sacri ced; the plasma and epididyms and testicles were harvested to the reproductive system studies. Our results highlighted that LP counteracted the harmful effect generated by FB1. Indeed; it induced sperm quality reduction, oxidative stress generation and histological alterations.In conclusion, the used strain was able to prevent FB1-reproductive system damages of in balb/c mice and could be valorised as an anti-cating agent in animal FB1-contaminated diet.

show abstract

ORIGINAL ARTICLE: Brain and hypophyseal acetylcholinesterase activity of pubertal boars fed dietary fumonisin B1

Cited by 7 publications

References 31 publications

Risks for animal health related to the presence of fumonisins, their modified forms and hidden forms in feed

Risks for animal health related to the presence of fumonisins, their modified forms and hidden forms in feed

Critical review evaluating the pig as a model for human nutritional physiology

The ameliorative effect of Lactobacillus paracasei BEJ01 against FB1 induced spermatogenesis disturbance, testicular oxidative stress and histopathological damage

Contact Info

Product

Resources

About