ORIGINAL ARTICLE: Squamous cell carcinoma of the oral tongue in patients younger than 30 years: clinicopathologic features and outcome

Soudry, Ethan; Preis, Michal; Hod, Roy; Hamzany, Yaniv; Hadar, Tuvia; Bahar, Gideon; Strenov, Yulia; Shpitzer, Thomas

doi:10.1111/j.1749-4486.2010.02164.x

Cited by 73 publications

(102 citation statements)

References 22 publications

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“…As for sample size, the number of participants ranged from 10 to 2,223 young subjects, as described in Table 1. Age distribution of patients varied: individuals considered young were those aged 18-39 years (7,8,10,11) (23.5%), < 30 years (13,20) (3,6,8,9,(11)(12)(13)(14)(16)(17)(18)(19)(20)(21) ( Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Among the 16 studies that associated SCC to the oral cavity, seven used only lesions in the tongue (3,6,8,12,13,15,20) as inclusion criteria; nine included other locations, of which six identified the tongue as the site of highest incidence (7, 9-11, 14, 16) , and just two observed predominance on the floor of mouth (18,21) . Concerning the relationship with harmful habits, nine investigations demonstrated association between tobacco and/or alcohol use and OSCC, of which six presented positive association (7,10,11,16,18,19) .…”

Section: Resultsmentioning

confidence: 99%

“…In young patients, aged less than 40 years, the oral squamous cell carcinoma (OSCC) is rare and represents 4%-6% of all the reported cases. However, there is an increasing tendency for this type of cancer to grow in tongue, base of tongue and tonsils in this age group (19,21) .…”

Section: Introductionmentioning

confidence: 99%

“…But the presence of such deleterious habits is not directly associated with OSCC in young adults, thanks to their short time of exposure (2,19) . OSCC etiopathogenesis has not been fully elucidated, and some factors like genetic alterations and human papillomavirus (HPV) infections have been pointed as possible causes for the development of OSCC in young patients (6,21) .…”

Section: Introductionmentioning

confidence: 99%

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Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

Mesquita¹,

Cavalvanti

Nonaka

et al. 2014

J. Bras. Patol. Med. Lab.

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The oral squamous cell carcinoma (OSCC) very often affects subjects above the sixth decade of life. However an increasing incidence has been observed in younger individuals, below 40 years. We conducted a systematized review of the current clinical, histopathological and therapeutic aspects of OSCC in young patients. Our work included studies that addressed OSCC involving young patients in the period 2007-2012, and which were indexed in PubMed. Initially, 499 articles were obtained; after refinement, 340 articles had their titles and abstracts evaluated, with 17 included in the sample. The majority of studies reported male predominance (87.5%), association with tobacco and/ or alcohol use (66.6%), advanced clinical stages at diagnosis (77.7%) and, at histopathology, moderately differentiated tumors (72.7%). Based on the results, we believe there are differences in the factors associated with pathogenesis, biological behavior and prognosis in young patients, since most studies show more rapid and aggressive tumor progression in this age group. We suggest the conduction of research focusing on the pathogenesis and carcinogenesis of OSCC in young patients, thereby searching for better scientific evidence.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

Mesquita¹,

Cavalvanti

Nonaka

et al. 2014

J. Bras. Patol. Med. Lab.

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show abstract

“…The incidence rate of HNSCC has reached 0.4-3.6% in patients younger than 40 years which has drawn physicians' attention to the changing face of the disease (Llewellyn et al, 2001). On the other hand, recent studies have revealed differences of the risk factors and prognosis of HNSCC, in patients younger than 40 and the older patients, although controversy still exists regarding disease outcomes in young and old patients: some authors report a worse prognosis of the disease in the young compared to the old (Mallet et al, 2009;Kaminagakura et al, 2010;Soudry et al, 2010;Bachar et al, 2011;Kostrzewska-Poczekaj et al, 2012) while other studies have not found a significant clinical difference, or even a more favorable prognosis in younger patients (Luna-Ortiz et al, 2011). In fact, even if the tumors are histologically more mature and less malignant in younger patients compared to older ones, they are usually more advanced clinically at the time of diagnosis due to late referral of young patients to physicians (Shiboski et al, 2005;Sink et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Head and Neck Squamous Cell Carcinoma in Iranian Patients and Risk Factors in Young Adults: a Fifteen-Year Study

Mafi

Kadivar²,

Hosseini³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: Head and neck squamous cell carcinoma (HNSCC) is the 8th most common cancer worldwide. Although older age, male gender, smoking and alcohol consumption are known risk factors, an increasing number of HNSCC patients are without typical risk factors. Our aim was to define demographics of HNSCC in Iran and the potential risk factors related to Iranian ethnicity and lifestyle. Methods: We conducted a crosssectional analytical study on 262 patients with primary SCC of the larynx, hypopharynx or tongue referred to our pathology department during 1995-2010. Patients' demographics, tumor characteristics and risk factors such as smoking, alcohol consumption and anemia were analyzed and compared in two groups of patients: over 40 years (older group) and 40 years or less (young group); Chi-square and Mann-Whitney analytical tests were employed. Results: 5.7% of patients were young adults. The male to female ratio was 1.5 in the younger group and 5.6 in the older group. In young adults, 40% of tumors were located in larynx and 40% in the tongue. Age >40 was significantly associated with laryngeal location (P<0.001). History of smoking and drinking was significantly associated with age >40 and SCC of larynx in both age groups. Cervical lymph node involvement was significantly correlated with SCC of tongue (P<0.001), however, considering young adults only, SCC of hypopharynx was most frequently accompanied by lymph node involvement (60%). The most prevalent tumor among men was SCC of larynx whereas SCC of hypopharynx was the most prevalent tumor among women (61%), of whom 18.2% were ≤40. Conclusions: The incidence of HNSCC among young adults seems to be higher in Iran compared to other countries. Reduction in exposure to known risk factors, especially tobacco smoking in forms of cigarettes and bubble pipes, and search for other causative agents of HNSCC in young population is recommended.

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A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

et al. 2021

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While evidence suggests an increasing incidence of tongue cancer in young adults, published findings regarding the prognostic role of age at diagnosis are inconsistent. We performed a meta‐analysis of the literature to highlight key points that might help in understanding the association between age of oral tongue cancer patients at diagnosis and their prognosis. According to age at diagnosis, a systematic literature review of all published cohort studies assessing the recurrence risks and mortality associated with tongue cancer was conducted. We compared the risk estimates between patients aged >45 years and those aged <45 years at diagnosis. Random‐effects models were used to calculate summary relative risk estimates (SRRs) according to different clinical outcomes and sources of between‐study heterogeneity (I2) and bias. We included 31 independent cohort studies published between 1989 and 2019; these studies included a total of 28,288 patients. When risk estimations were not adjusted for confounders, no significant association was found between age at diagnosis and overall survival (OS). Conversely, after adjustment for confounders, older age at diagnosis was associated with a significantly increased risk of mortality. The difference between SRRs for adjusted and unadjusted estimates was significant (p < 0.01). Younger patients had a significantly higher risk of local recurrence. Younger patients with oral tongue cancer have better OS but a greater risk of recurrence than older patients. These findings should be validated in a large prospective cohort study which considers all confounders and prognostic factors.

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ORIGINAL ARTICLE: Squamous cell carcinoma of the oral tongue in patients younger than 30 years: clinicopathologic features and outcome

Cited by 73 publications

References 22 publications

Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

Head and Neck Squamous Cell Carcinoma in Iranian Patients and Risk Factors in Young Adults: a Fifteen-Year Study

A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

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