Original Articles: Testis Cancer: A Review of Scrotal Violation in Testicular Cancer: Is Adjuvant Local Therapy Necessary?

Capelouto, Carl C.; Clark, Peter E.; Ransil, Bernard J.; Loughlin, Kevin R.

doi:10.1016/s0022-5347(01)67617-1

Cited by 81 publications

(36 citation statements)

References 27 publications

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“…2,3 Radical inguinal orchiectomy with high ligation of the spermatic cord is the standard of care in initial treatment of testicular cancer. 4 The inguinal approach is preferred over scrotal manipulations to prevent disturbance to lymphatic drainage, and thus avoiding potential spread of disease. 5 Violation of the scrotum is defined as any trans-scrotal intervention that can impact tumour seeding.…”

Section: Introductionmentioning

confidence: 99%

“…5 Scrotal violation in relation to testicular cancer can include open testicular biopsy, fine-needle aspiration, trans-scrotal orchiectomy or previous repair of inguinal hernias, and hydrocolectomies. 4,5 In such cases, a variety of adjuvant treatments, including hemiscrotectomy, inguinal lymph node dissection, local radiation, and chemotherapy, have been suggested. 4 These subsequent treatments are aimed at preventing recurrence of disease and can often adversely affect patient morbidity.…”

Section: Introductionmentioning

confidence: 99%

“…4,5 In such cases, a variety of adjuvant treatments, including hemiscrotectomy, inguinal lymph node dissection, local radiation, and chemotherapy, have been suggested. 4 These subsequent treatments are aimed at preventing recurrence of disease and can often adversely affect patient morbidity.…”

Section: Introductionmentioning

confidence: 99%

“…Local recurrence involves disease in the scrotal or inguinal regions, including superficial lymph nodes. 4 Distant recurrence includes all other sites, including biochemical recurrence seen by a rise in serum tumour markers. 4,5 In a review by Capelouto et al, local recurrence rates for testicular cancer were significantly different between patients who underwent inguinal orchiectomies (0.4%) and scrotal violation patients (2.9%).…”

Section: Introductionmentioning

confidence: 99%

“…4 Distant recurrence includes all other sites, including biochemical recurrence seen by a rise in serum tumour markers. 4,5 In a review by Capelouto et al, local recurrence rates for testicular cancer were significantly different between patients who underwent inguinal orchiectomies (0.4%) and scrotal violation patients (2.9%). 4 Meta-analysis of 1182 cases showed an increased rate of local recurrence in scrotal violation patients, especially for individuals presenting with stage I disease.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Scrotal recurrence of germ cell tumour in a non-violated scrotum

Power

2016

CUAJ

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Testicular cancer is the most common cancer diagnosis in males aged 15-30 years. For over a century, radical inguinal orchiectomy has been the standard of care for initial treatment of testicular cancer. This approach is preferred over trans-scrotal interventions, in an effort to avoid tumour seeding, spermatic cord invasion, and disturbance to lymphatic drainage. Scrotal violation is defined as any trans-scrotal intervention that may impact spread of disease in testicular cancer, including scrotal orchiectomy, fine-needle aspiration, and testicular biopsy. Studies have shown statistically significant differences in local recurrence rates between patients who undergo the standard inguinal surgical approach and cases with scrotal violation.Over 95% of testicular cancers are curative, often with surgery alone. Recurrence of disease is divided into two categories: local and distant sites. Local recurrence of testicular cancer involves the scrotal and inguinal regions, including superficial inguinal lymph nodes. More commonly, local recurrence is seen in cases of testicular cancer with scrotal violation. We describe a case of local recurrence of testicular cancer in a non-violated scrotum, a finding that has not been previously reported in the literature.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Scrotal recurrence of germ cell tumour in a non-violated scrotum

Power

2016

CUAJ

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Surgery for Testicular Cancer

Hendry¹

2002

Treatment Options in Urological Cancer

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Testis Cancer

Kollmannsberger

Nichols

Daneshmand³

et al. 2017

Holland‐Frei Cancer Medicine

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Overview Cancer of the testis is a relatively uncommon disease, accounting for approximately 1% of all cancers in males. However, it represents a highly curable neoplasm, the incidence of which is focused on young patients at their peak of productivity. Curative treatment of disseminated nonseminomatous germ cell tumors often combines surgery and chemotherapy. The goal of initial therapy is never palliation or prolongation of survival, but cure.

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Original Articles: Testis Cancer: A Review of Scrotal Violation in Testicular Cancer: Is Adjuvant Local Therapy Necessary?

Cited by 81 publications

References 27 publications

Scrotal recurrence of germ cell tumour in a non-violated scrotum

Scrotal recurrence of germ cell tumour in a non-violated scrotum

Surgery for Testicular Cancer

Testis Cancer

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