Original targeted therapy for the management of the burnout syndrome in nurses: an innovative approach and a new opportunity in the context of predictive, preventive and personalized medicine

Stress and Burnout Among Social Workers in The VUCA world of COVID-19 Pandemic

“…Currently considered an occupational disease, the burnout syndrome affects 13-27% of the active population in multiple occupational sectors of the modern world [24]. It was introduced in the 10th Revision of the International Classification of Diseases (ICD-10) and recently revised by the World Health Organization within ICD-11 as an occupational phenomenon and not as a medical condition: "a syndrome conceptualized as resulting from chronic workplace stress that has not been successfully managed.…”

“…Burnout impairs the social workers' professional functioning and consequently their ability to provide quality services to the clients that they serve [36]. The clinical picture of the burnout syndrome comprises a complex interplay of physical and psychological symptoms, an association of symptoms of social dysfunction, psychosomatic and somatic disorders, emotional and psychological distress [24].…”

“…For quantitative data, the Copenhagen Burnout Inventory was used [23,31], the version translated into Romanian (CBI-R). [24] The CBI-R consists of 18 questions which differentiate between personal burnout (PB), work-related burnout (WB) and client-related burnout (CB). It is more suitable to the pandemic situation, which posed a lot of stress on both personal life and work, also the nature of relationship with clients changed dramatically.…”

Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope?

“…Accumulated evidence suggests a tight association between chronic stress and psychiatric disorders [ 17 – 21 ]. Especially severe, prolonged and/or chronic stress of any origin such as exercise-induced oxidative stress [ 22 ] (see “ Physical activity and exercise-induced oxidative stress ” section), hormonal stress [ 23 ], emotional stress and psychological burden [ 24 – 27 ] as well as metabolic stress, e.g. in diabetes mellitus [ 28 , 29 ] (see also below “ Association between diabetes mellitus and carcinogenesis: diagnostic and therapeutic potential of cell-free nucleic acids ” section) and hyperhomocysteinaemia [ 30 , 31 ] amongst others, is associated with highly increased ROS production and insufficient repair capacity—both linked to oxidative damage of mitochondria and consequent mitochondrial dysfunction leading to the development of cardiovascular impairments [ 32 – 34 ], neuro/degenerative pathologies [ 34 – 37 ], impaired healing [ 34 ] and malignant cell transformation [ 34 , 38 – 42 ].…”

“…Regular physical activity defined as movements of body mediated by skeletal muscles resulted in the energy expenditure usually measured in kilocalories [ 57 ] has been demonstrated as being crucial for physical and mental health benefits [ 58 ], prevention of various diseases including metabolic syndrome, obesity, insulin resistance, atherosclerosis, diabetes, neurodegenerative diseases and cancers [ 23 – 27 ]. Regular individually adapted exercise has an ability to inhibit ROS production, ameliorates the antioxidant capacity and improves mitochondria efficiency reducing oxidative stress and cellular damage [ 59 ].…”