Ornamental Asteraceae Species as New Sources of Secondary Metabolites

Burlec, Ana Flavia; Arsene, Cristina Cerasela; Gille, Elvira; Hăncianu, Monica; Cioancă, Oana

doi:10.5530/ijper.51.3s.61

Cited by 7 publications

(4 citation statements)

References 8 publications

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“…Our results complete some of the most recent studies on Asteraceae species, sustaining that such species are important resources, but care should be taken when handling the raw plant material which can induce contact dermatitis [23]. Previous studies sustain such claim by confirming the presence of alantolactone, a sesquiterpene lactone recognized for its allergenic properties [3,21]. However, sesquiterpene lactones also possess important pharmacological benefits (antioxidant, anti-inflammatory, antimicrobial and anticancer activities) [4,15].…”

Section: Ferrous Ion Chelating Activitysupporting

confidence: 81%

Antioxidant and Antimicrobial Properties of Chrysanthemum and Tagetes Selective Extracts

Burlec¹

2019

FARMACIA

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The present study focuses on two ornamental species of the Asteraceae family and their biological properties, which can be correlated with the presence of different classes of natural compounds. Given the fact that secondary metabolites found in such plants can be used as valuable resources for the pharmaceutical industry, we chose to investigate the biological potential of Chrysanthemum indicum and Tagetes erecta inflorescences. Four types of extracts were obtained for each species, using organic solvents with different polarities. Bioactive compounds such as polyphenols were quantitatively analysed using a the Folin-Ciocâlteu method. The investigated compounds were present in all types of extracts in variable quantities, the highest amounts being found in the methanolic extracts. Positive dose-related values revealed that the investigated extracts exhibit good inhibitory activity against 15-lipoxygenase and a moderate metal-chelating activity. Moreover, all extracts showed promising antibacterial and antifungal activities on the tested strains. RezumatPrezentul studiu se axează pe analiza unor specii ornamentale din familia Asteraceae și pe testarea acțiunilor lor biologice ce pot fi corelate cu prezența diferitelor clase de compuși naturali. Având în vedere faptul că metaboliții ai acestor plante pot fi utilizați ca resurse valoroase pentru industria farmaceutică, am ales să investigăm inflorescențele speciilor Chrysanthemum indicum și Tagetes erecta. Pentru fiecare specie au fost obținute patru tipuri de extracte, utilizând solvenți organici cu polarități diferite. Compușii bioactivi, precum polifenolii, au fost analizați cantitativ utilizând metoda spectrofotometrică. Compușii investigați s-au regăsit în toate tipurile de extracte în proporții variabile, cele mai mari cantități regăsindu-se în extractele metanolice. În ceea ce privește testarea acțiunilor biologice, valorile obținute au evidențiat faptul că extractele analizate prezintă o bună activitate inhibitorie asupra 15-lipooxigenazei și o activitate moderată de chelatare a ionului feros. Mai mult, toate extractele obținute din speciile investigate au prezentat activități antibacteriene și antifungice promițătoare asupra tulpinilor testate.

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Section: Ferrous Ion Chelating Activitysupporting

confidence: 81%

Antioxidant and Antimicrobial Properties of Chrysanthemum and Tagetes Selective Extracts

Burlec¹

2019

FARMACIA

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“…Plants from Asteraceae are a source of polyphenol content and antioxidant activity (Burlec et al 2017). The representatives of the Artemisia genus are no exception and are of scientific interest as a source of antioxidants.…”

Section: Discussionmentioning

confidence: 99%

Genotype Variation of Polyphenol Content and Antioxidant Activity of Artemisia balchanorum Krasch. × Artemisia taurica Willd

Vergun,

Svydenko,

Grygorieva

et al. 2023

Agriculture (Pol'nohospodárstvo)

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The results of seasonal variation of total polyphenols (TPC), flavonoids (TFC) and phenolic acid (TPAC) accumulation and antioxidant activity of Artemisia balchanorum Krasch. × Artemisia taurica Willd. genotypes from the Kherson Oblast of Ukraine represented in this study. The total polyphenol content was identified by the Folin-Ciocalteu method and ranged from 20.51 to 132.52 mg GAE/g (gallic acid equivalent). The flavonoid content conducted with aluminum chloride reagent ranged from 8.16 to 70.77 mg QE/g (quercetin equivalent) and phenolic acid content determined with Arnova reagent ranged from 6.26 to 38.67 mg CAE/g (caffeic acid equivalent) depending on genotype and stage of growth. The antioxidant activity of investigated genotypes determined by the DPPH (2.2-diphenyl-1-picrylhydrazyl) method (FRSA) varied from 4.68 to 10.38 mg TE/g (Trolox equivalent), molybdenum-reducing power of extracts detected by the phosphomolybdenum method (MRP) and was from 41.43 to 209.93 mg TE/g depending on genotype. The total polyphenol content, flavonoids and antioxidant activity by the phosphomolybdenum method increased from spring vegetation to flowering. The accumulation of phenolic acids and antioxidant activity by the DPPH method was uneven and depended on genotype and stage of growth. It was found a weak correlation between FRSA and TPC (r = 0.189), TFC (r = 0.211), and TPAC (r = 0.111) for genotypes. A strong correlation was found between MRP and TPC (r = 0.703), and TFC (r = 0.657). A moderate correlation was detected between MRP and TPAC (r = 0.481) for genotypes. The obtained data can be used for further breeding work to get genotypes with high antioxidant activity.

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“…In total, the database contained 196 Asteraceae metabolites and 44 compounds with reported inhibitory effect originating from various plant sources. The database is provided as an Excel file in the Supplementary Materials and used references are reported here [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ]. To evaluate the results generated based on the suspect list screening, the SCIEX OS (version 1.5.0.23389, Vaughan, ON, Canada) software was used.…”

Section: Methodsmentioning

confidence: 99%

The In Vitro Inhibitory Effect of Selected Asteraceae Plants on Pancreatic Lipase Followed by Phenolic Content Identification through Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS)

Tsagkaris

Louckova

Jaegerova

et al. 2022

IJMS

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Pancreatic lipase (PNLIP, EC 3.1.1.3) plays a pivotal role in the digestion of dietary lipids, a metabolic pathway directly related to obesity. One of the effective strategies in obesity treatment is the inhibition of PNLIP, which is possible to be achieved by specific phenolic compounds occurring in high abundance in some plants. In this study, a multidisciplinary approach is presented investigating the PNLIP inhibitory effect of 33 plants belonging in the Asteraceae botanical family. In the first stage of the study, a rapid and cost-efficient PNLIP assay in a 96-microwell plate format was developed and important parameters were optimized, e.g., the enzyme substrate. Upon PNLIP assay optimization, aqueous and dichloromethane Asteraceae plant extracts were tested and a cut-off inhibition level was set to further analyze only the samples with a significant inhibitory effect (inhibitory rate > 40%), using an ultra-high-performance liquid chromatography hybrid quadrupole time-of-flight mass spectrometry (UHPLC-q-TOF-MS) method. Specifically, a metabolomic suspect screening was performed and 69 phenolic compounds were tentatively identified, including phenolic acids, flavonoids, flavonoid-3-O-glycosides, and flavonoid-7-O-glycosides, amongst others. In the case of aqueous extracts, phytochemicals known for inducing PNLIP inhibitory effect, e.g., compounds containing galloyl molecules or caffeoylquinic acids, were monitored in Chrysanthemum morifolium, Grindella camporum and Hieracium pilosella extracts. All in all, the presented approach combines in vitro bioactivity measurements to high-end metabolomics to identify phenolic compounds with potential medicinal and/or dietary applications.

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Ornamental Asteraceae Species as New Sources of Secondary Metabolites

Cited by 7 publications

References 8 publications

Antioxidant and Antimicrobial Properties of Chrysanthemum and Tagetes Selective Extracts

Antioxidant and Antimicrobial Properties of Chrysanthemum and Tagetes Selective Extracts

Genotype Variation of Polyphenol Content and Antioxidant Activity of Artemisia balchanorum Krasch. × Artemisia taurica Willd

The In Vitro Inhibitory Effect of Selected Asteraceae Plants on Pancreatic Lipase Followed by Phenolic Content Identification through Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS)

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