Ornithine and its role in metabolic diseases: An appraisal

Sivashanmugam, Muthukumaran; Jaidev, J; Umashankar,; Sulochana, K N

doi:10.1016/j.biopha.2016.12.024

Cited by 99 publications

(52 citation statements)

References 54 publications

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“…Further exploration of the roles of each of these metabolites and genes can help guide future research endeavours. For example, ornithine, produced via the urea cycle, is a non-essential amino acid (59). The substrate action of ornithine can lead to excessive polyamine synthesis which plays a role in modulating the development of certain types of cancer (59,60).…”

Section: Discussionmentioning

confidence: 99%

An 8-Week Freeze-Dried Blueberry Supplement Impacts Immune-Related Pathways: A Randomized, Double-Blind Placebo-Controlled Trial

Rousseau

Horne

Guénard

et al. 2020

Preprint

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Background: Blueberries contain high level of polyphenolic compounds with high in vitro antioxidant capacities. Their consumption has been associated with improved vascular and metabolic health.Purpose: The objective was to examine the effects of blueberry supplement consumption on metabolic syndrome (MetS) parameters and potential underlying mechanisms of action. Methods: A randomized double-blind placebo-controlled intervention trial was conducted in adults at risk of developing MetS. Participants consumed 50g daily of either a freeze-dried highbush blueberry powder (BBP) or a placebo powder for 8 weeks (n=49). MetS phenotypes were assessed at week 0, 4 and 8. Fasting blood gene expression profiles and plasma metabolomic profiles were examined at baseline and week 8 to assess metabolic changes occurring in response to the BBP. A per-protocol analysis was used. Results: Interaction effects were non-significant demonstrating that compared to the placebo, BBP had no statistically significant effect on body weight, blood pressure, fasting plasma lipid, insulin and glucose levels, insulin resistance (or sensitivity) and on glycated hemoglobin concentrations. However, there were significant within- and between-group differences including increased insulin resistance in the placebo group only, greater TG at week 4 in the BBP compared to placebo group and increased fasting insulin from week 4 to 8 in both groups. Moreover, there were significant changes in the expression of 49 genes and 35 metabolites following BBP consumption. Differentially regulated genes were clustered in immune-related pathways.Conclusion: An 8-week BBP intervention did not significantly improve traditional markers of cardiometabolic health in adults at risk of developing MetS. However, metabolically relevant changes in gene expression and metabolites suggest that clinically significant cardiometabolic changes could take longer than 8 weeks to present and/or could result from whole blueberry consumption or a higher dosage. BBP may also have an effect on factors such as immunity even within a shorter 8-week timeframe. Clinical trial registration: clinicaltrials.gov, NCT03266055, 2017, https://clinicaltrials.gov/ct2/show/NCT03266055?term=blueberry+vohl&draw=2&rank=1

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Section: Discussionmentioning

confidence: 99%

An 8-Week Freeze-Dried Blueberry Supplement Impacts Immune-Related Pathways: A Randomized, Double-Blind Placebo-Controlled Trial

Rousseau

Horne

Guénard

et al. 2020

Preprint

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“…PAs específicamente la ornitina (Sivashanmugam, 2017), pero se requiere de estudios en el mismo modelo y niveles de Por una parte en octubre, en el que la marea es más alta, los corales pueden estar propensos a la turbulencia y presión de una mayor columna de agua, radiación solar con una menor inclinación, y mayores temperaturas ambientales y del agua de clarity of it, to name a few; and stress indicators, although those already established for this type of study, act as a response to more demanding environmental conditions (Sosa-Avalos et al, 2006). In such a way that Spd and Spm can represent an adaptive mechanism to conditions of less productivity around October, if considered as a stress condition, increasing its concentration to favor metabolic pathways of stress indicator molecules, like MAAs and given the vast relation of PAs precursor amino acid, specifically ornithine (Sivashanmugam et al, 2017), in this model, but studies in the same model and PAs levels are required, in addition to those already established indicators.…”

Section: Clorofilas Carotenoides Nutrientes Y/o La Biomasa Presentesmentioning

confidence: 99%

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Reynoso-Orozco

Ramirez²,

Torres-Ortiz³

et al. 2019

rbio

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“…L-ORN is a non-proteinogenic amino acid, which is not coded naturally in the DNA, and is produced as an intermediate component of the urea cycle. [3][4][5] L-ORN is one of the OTC dietary supplements that is commonly used by athletes where it is thought to have a role in increasing the mass of the muscles, as well as an ability to enhance the performance through increasing strength, the production of Human Growth Hormone (HGH) and improving fat metabolism. Moreover, L-ORN has a main role in burning up excess fat in the body and is used for enhancing the workability of the immune system.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, L-ORN has a main role in burning up excess fat in the body and is used for enhancing the workability of the immune system. [3][4][5][6][7] Several techniques were reported in the literature for the determination of L-ORN. These techniques are mainly chromatography based.…”

Section: Introductionmentioning

confidence: 99%

Utilization of 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) for spectrochemical determination ofl-ornithine: a multivariate optimization-assisted approach

2019

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A simple and highly sensitive univariate calibration strategy based on ultraviolet-visible (UV-Vis) absorption spectroscopy and assisted by multivariate screening and optimization was utilized for the determination of L-ornithine (L-ORN) as such and in the alimentary supplements. L-ORN, an OTC marketed amino acid, is widely used for bodybuilding and might be abused by athletes. A nucleophilic substitution reaction using 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) was the basis of the current investigation. Plackett-Burman design (PBD) and a response surface optimizer as screening and fine-tuning strategies, respectively, were instigated. Four numerical variables, reaction time (RT), temperature (Temp), pH and reagent volume (RV), and one categorical variable, the diluting solvent (DS), were considered.Absorbance of the yellow-colored adduct at 469 nm was the response studied. Pareto analysis, along with analysis of variance (ANOVA) were used to ascertain the significant variables (screening phase) and their domains (optimization phase). Response transformation and stepwise analysis were employed when necessary. Probability, cube and individual value plots were used to get an insight into the statistical impact of the variables tested. Multiple responses' optimization was performed using Derringer's function. Calibration curves were linear in the range of 5-50 mg mL À1 . Job's technique of continuous variation showed that the stoichiometric ratio is 2 : 1 (NBD-Cl : L-ORN). The proposed technique was successfully applied to the dietary supplements of L-ORN, inferring no interference from adjuvants and excipients. Analytical performance of this technique was validated conforming to the ICH standards.Scheme 1 L-Ornithine monohydrochloride (L-ORN). a Null hypothesis: H 0 : m 1 À m 2 ¼ 0. Alternative hypothesis: H 1 : m 1 À m 2 s 0. T-value ¼ 0.94, DF: 8; P-value ¼ 0.374. This journal is a Mean AE SD of 3 determinations. (a) The intra-day (n ¼ 3) average of three concentrations of L-Ornithine repeated three times within the same day. (b) The inter-day (n ¼ 3) average of three concentrations of L-ORN repeated three times in three different days.22112 | RSC Adv., 2019,9,[22106][22107][22108][22109][22110][22111][22112][22113][22114][22115] This journal is

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Ornithine and its role in metabolic diseases: An appraisal

Cited by 99 publications

References 54 publications

An 8-Week Freeze-Dried Blueberry Supplement Impacts Immune-Related Pathways: A Randomized, Double-Blind Placebo-Controlled Trial

An 8-Week Freeze-Dried Blueberry Supplement Impacts Immune-Related Pathways: A Randomized, Double-Blind Placebo-Controlled Trial

Untitled

Utilization of 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) for spectrochemical determination ofl-ornithine: a multivariate optimization-assisted approach

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