Orofacial clefts: A compendium on non‐syndromic cleft lip–cleft palate

Coletta, Ricardo D.; Sunavala‐Dossabhoy, Gulshan

doi:10.1111/odi.14238

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Regarding alcohol consumption, there was no statistical significance observed in this study, although there is strong evidence indicating an association between alcohol use during pregnancy and the occurrence of oral clefts. 26 One possible explanation for the lack of association in this particular study could be the small number of participants who reported alcohol consumption during pregnancy in both the case and control groups. 27 …”

Section: Discussionmentioning

confidence: 74%

Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts

Andrade

Oliveira

Martelli

et al. 2023

Clinics

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Section: Discussionmentioning

confidence: 74%

Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts

Andrade

Oliveira

Martelli

et al. 2023

Clinics

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“…The most popular classification divides NSOC into three main subtypes, NSCLO, NSCLP, and NSCPO. 25 , 38 Although not universally accepted, due to similarities in epidemiological characteristics and embryological timing, many studies combine NSCLO and NSCLP into a single group: NSCL±P. 38 , 39 Therefore, the analyses were carried out with these subgroups.…”

Section: Discussionmentioning

confidence: 99%

“… 25 , 38 Although not universally accepted, due to similarities in epidemiological characteristics and embryological timing, many studies combine NSCLO and NSCLP into a single group: NSCL±P. 38 , 39 Therefore, the analyses were carried out with these subgroups. The association between the polymorphism in rs566926 – WNT5A was found only in the NSCLO group, influencing a potential association with a nominal p-value in the NSCL±P group.…”

Section: Discussionmentioning

confidence: 99%

Exploring the role of the WNT5A rs566926 polymorphism and its interactions in non-syndromic orofacial cleft: a multicenter study in Brazil

LARA,

COLETTA,

Assis MACHADO

et al. 2024

J. Appl. Oral Sci.

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Associations between the WNT5A rs566926 variant and non-syndromic orofacial cleft (NSOC) have been reported in different populations. Objective This study aimed to investigate the role of the rs566926 single nucleotide polymorphism (SNP) in WNT5A and its interactions with SNPs in BMP4, FGFR1, GREM1, MMP2 , and WNT3 in the occurrence of NSOC in a Brazilian population. Methodology A case-control genetic association study was carried out involving participants from four regions of Brazil, totaling 801 patients with non-syndromic cleft lip with or without cleft palate (NSCL±P), 273 patients with cleft palate only (NSCPO), and 881 health volunteers without any congenital condition (control). Applying TaqMan allelic discrimination assays, we evaluated WNT5A rs566926 in an ancestry-structured multiple logistic regression analysis, considering sex and genomic ancestry as covariates. Interactions between rs566926 and variants in genes involved in the WNT5A signaling pathway ( BMP4, FGFR1, GREM1, MMP2 , and WNT3 ) were also explored. Results WNT5A rs566926 was significantly associated with an increased risk of NSCL±P, particularly due to a strong association with non-syndromic cleft lip only (NSCLO), in which the C allele increased the risk by 32% (OR: 1.32, 95% CI: 1.04–1.67, p=0.01). According to the proportions of European and African genomic ancestry, the association of rs566926 reached significant levels only in patients with European ancestry. Multiple interactions were detected between WNT5A rs566926 and BMP4 rs2071047, GREM1 rs16969681 and rs16969862, and FGFR1 rs7829058. Conclusion The WNT5A rs566926 polymorphism was associated with NSCL±P, particularly in individuals with NSCLO and high European ancestry. Epistatic interactions involving WNT5A rs566926 and variants in BMP4, GREM1 , and FGFR1 may contribute to the risk of NSCL±P in the Brazilian population.

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Integrating transcriptomics and genomics to identify fibroblast growth factor/receptor candidate genes for non‐syndromic orofacial cleft in Chinese

Lin

Shi

et al. 2023

Archives of Oral Biology

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Orofacial clefts: A compendium on non‐syndromic cleft lip–cleft palate

Cited by 4 publications

References 9 publications

Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts

Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts

Exploring the role of the WNT5A rs566926 polymorphism and its interactions in non-syndromic orofacial cleft: a multicenter study in Brazil

Integrating transcriptomics and genomics to identify fibroblast growth factor/receptor candidate genes for non‐syndromic orofacial cleft in Chinese

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