Orotic acid improves left ventricular recovery four days after heterotopic transplantation

Myocardial Infarct Size-Limiting and Anti-Arrhythmic Effects of Mildronate Orotate in the Rat Heart

“…Thus, orotic acid increased the glycogen content of the rat heart and significantly improved post-ischemic myocardial function both in vivo and in vitro in rat hearts subjected to 30 min of global noflow ischemia followed by 10 min of reperfusion [29]. Orotic acid also accelerated compensatory myocardial hypertrophy after regional ischemia and improved left ventricular function after acute global ischemia [19]. The effect of orotic acid was also shown for myocardial degeneration and the development of congestive heart failure in cardiomyopathic hamsters of the UMX7.1 line, where it prolonged survival of the experimental animals [30].…”

“…Thus, both orotic acid and its salt, orotate, have been shown to improve markedly the function of the heart in hypertrophy, infarction, global ischemia and related conditions [16][17][18][19]. The pharmacological effect of orotic acid is thought to rely on the activation of anaerobic metabolism through maintenance of glycogen stores, significant increase in protein synthesis, and nucleotide metabolism [20,21].…”